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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Management of Congenital Heart Disease (CHD)
edited by Sarah Nordmeyer and Marie Schafstedde
submission deadline 10 Feb 2026 | 2 articles | Viewed by 511 | Submission Open
Keywords: congenital heart disease; imaging; diagnostics; surgical innovations; minimally invasive interventions
(This special issue belongs to the Section Cardiovascular Medicine)
Minimally Invasive Approaches to Urolithiasis and Upper Urinary Tract Transitional Cell Carcinoma: Current Evidence
edited by
submission deadline 10 Feb 2026 | Viewed by 231 | Submission Open
Keywords: extracorporeal shock wave lithotripsy; lasers; percutaneous lithotripsy; robotic surgery; ureteroscopy; urolithiasis
(This special issue belongs to the Section Nephrology & Urology)
Hearing Disorders: Diagnosis, Management, and Future Opportunities: 4th Edition
edited by
submission deadline 10 Feb 2026 | Viewed by 144 | Submission Open
Keywords: middle ear surgery; otosclerosis; sensorineural hearing loss; sudden hearing; cochlear implant
(This special issue belongs to the Section Otolaryngology)
Clinical Advances in Spine Disorders—2nd Edition submission deadline 10 Feb 2026 | Viewed by 119 | Submission Open
Keywords: spine disorders; lumbar spine surgery; minimally invasive surgery; spine surgery; microneurosurgery
(This special issue belongs to the Section Clinical Neurology)
Recent Concepts in Ovarian Cancer: Epidemiology, Diagnosis, Treatment and Quality of Life
edited by Giulia Scotto and
submission deadline 10 Feb 2026 | Viewed by 110 | Submission Open
Keywords: ovarian cancer; quality of life; multidisciplinary care; personalized medicine; PARP inhibitors
(This special issue belongs to the Section Oncology)
Clinical Advances in Pain Management
edited by Jamal Hasoon and Omar Viswanath
submission deadline 13 Feb 2026 | 11 articles | Viewed by 16660 | Submission Open
Keywords: postoperative pain; acute pain; chronic pain; nociceptive; analgesia; analgesics; interventional pain procedures
(This special issue belongs to the Section Anesthesiology)
Systemic Lupus Erythematosus: Current Trends and Therapeutic Innovations
edited by Giuseppe Barilaro
submission deadline 15 Feb 2026 | 4 articles | Viewed by 4310 | Submission Open
Keywords: systemic lupus erythematosus; autoantibodies; biomarkers; therapeutic drugs; lupus nephritis; quality of life; new treatment strategies
(This special issue belongs to the Section Immunology & Rheumatology)
Periodontal Diseases and Systemic Health: Pathogenesis, Prevention and Management
edited by Saverio Cosola
submission deadline 15 Feb 2026 | 3 articles | Viewed by 3316 | Submission Open
Keywords: periodontitis; dental implants; systemic inflammation; diabetes and periodontal disease; cardiovascular implications; pregnancy and oral health; host immune responses; preventive dentistry; implant-prosthetic rehabilitation
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Pancreatic Disorder, Pancreatitis, and Pancreatic Cancer: Interconnections, Clinical Challenges, and Therapeutic Advances
edited by Cristian George Ţieranu and
submission deadline 15 Feb 2026 | 1 articles | Viewed by 2977 | Submission Open
Keywords: pancreatic disorder; pancreatitis; pancreatic cancer; translational research; diagnosis; treatment
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Cardiac Electrophysiology: Focus on Clinical Practice submission deadline 15 Feb 2026 | 2 articles | Viewed by 2302 | Submission Open
Keywords: cardiomyopathy; arrhythmia; heart rhythm; atrial fibrillation; ventricular tachycardia; sudden cardiac death; mapping; ablation; pulsed field ablation (PFA); device; pacemaker; left bundle branch area pacing (LBBAP); conduction system pacing (CSP); implantable cardioverter-defibrillator (ICD); leadless pacing; extraction
(This special issue belongs to the Section Cardiology)
Current Concepts and Updates in Eye Diseases
edited by Wiktor Stopyra, and Anna Machalinski
submission deadline 15 Feb 2026 | 2 articles | Viewed by 1967 | Submission Open
Keywords: corneal disease; glaucoma; cataract; uveitis; ocular oncology; retinal disorder; ocular treatment; eye surgery; ocular diagnostics
(This special issue belongs to the Section Ophthalmology)
Bariatric Surgery: Challenges and Future Trends
edited by Hugo Santos-Sousa
submission deadline 15 Feb 2026 | 2 articles | Viewed by 1626 | Submission Open
Keywords: obesity; metabolic and bariatric surgery; sleeve gastrectomy; metabolic syndrome; novel surgical procedures; Nissen-sleeve fundoplication; Roux-en-Y gastric bypass distalization; single-anastomosis procedures
(This special issue belongs to the Section General Surgery)
New Insight into Pain and Chronic Pain Management
edited by
submission deadline 15 Feb 2026 | 1 articles | Viewed by 1612 | Submission Open
Keywords: chronic pain; pain management; pharmacological treatment; non-pharmacological interventions; neuromodula-tion; multidisciplinary approaches; personalized medicine; quality of life
(This special issue belongs to the Section Clinical Rehabilitation)
Catheter Ablation of Cardiac Arrhythmias: Current Updates and Perspectives: 2nd Edition
edited by
submission deadline 15 Feb 2026 | 1 articles | Viewed by 1479 | Submission Open
Keywords: ablation; arrhythmia; electrophysiology; atrial fibrillation; atrial flutter; atrial tachycardia; mapping; supraventricular tachycardia; ventricular arrhythmia
(This special issue belongs to the Section Cardiology)
Drug-Related Problems: Clinical Pharmacy and Safety of Pharmacotherapy submission deadline 15 Feb 2026 | 1 articles | Viewed by 1431 | Submission Open
Keywords: adverse drug reaction; drug-related problems; drug formulation technology; safety of pharmacotherapy; clinical pharmacy; pharmaceutical care; pharmacology
(This special issue belongs to the Section Pharmacology)
New Insights in Neonatal Intensive Care
edited by , and Martina Ciarcià
submission deadline 15 Feb 2026 | Viewed by 787 | Submission Open
Keywords: neonatal intensive care; neonatal diseases; critically ill infants; premature infants; neonatal care; intensive care medicine
(This special issue belongs to the Section Clinical Pediatrics)
Advances in Traumatic Brain Injury: Causes and Recovery
edited by Antonio Bonora
submission deadline 15 Feb 2026 | Viewed by 250 | Submission Open
Keywords: mild traumatic brain injury; TBI; brain injuries; neuroimaging; rehabilitation
(This special issue belongs to the Section Brain Injury)
Kidney Transplantation: Current Challenges and Future Perspectives: 2nd Edition
edited by Alberto Piana and Angelo Territo
submission deadline 15 Feb 2026 | Viewed by 171 | Submission Open
Keywords: kidney transplantation; urologic cancers; organ preservation; surgical challenges; donor selection; long-term outcomes; complications; post-transplant care; technology
(This special issue belongs to the Section Nephrology & Urology)
Recent Advances in Refractive Surgery and Intraocular Lens Implantation
edited by Antonio Leccisotti
submission deadline 15 Feb 2026 | Viewed by 165 | Submission Open
Keywords: refractive surgery; intraocular lens implantation; keratectomy; cornea; ocular surgery; optical coherence tomography; laser surgery; KLEx (keratorefractive lenticule extraction); femtolasik
(This special issue belongs to the Section Ophthalmology)
Clinical Diagnosis and Surgical Strategies Update on Ear Disorders: 2nd Edition submission deadline 15 Feb 2026 | Viewed by 123 | Submission Open
Keywords: middle ear; inner ear; endoscopic ear surgery; cholesteatoma; Meniè re’ s disease; hearing loss; robotic surgery; oto-sclerosis
(This special issue belongs to the Section Otolaryngology)
State of the Art in Bladder Cancer: Diagnostics and Treatment Strategies
edited by
submission deadline 15 Feb 2026 | Viewed by 103 | Submission Open
Keywords: bladder cancer; photodynamic diagnosis (PDD); bladder-sparing strategies; robotic-assisted surgery; single-port robotic cystectomy; older patients; immunotherapy; intravesical therapy; bladder preservation; minimally invasive urology; advanced bladder cancer; diagnostic innovation
(This special issue belongs to the Section Nephrology & Urology)
Clinical Perspectives in Amyotrophic Lateral Sclerosis: Diagnosis, Management and Future Opportunities
edited by
submission deadline 15 Feb 2026 | Viewed by 98 | Submission Open
Keywords: amyotrophic lateral sclerosis; early diagnosis; neuroimaging; biomarkers; treatment
(This special issue belongs to the Section Clinical Neurology)
Eosinophilic Esophagitis: Clinical Advances in Diagnosis, Treatment, and Monitoring
edited by Pierfrancesco Visaggi, Edoardo Vincenzo Savarino and
submission deadline 18 Feb 2026 | 4 articles | Viewed by 5852 | Submission Open
Keywords: eosinophilic esophagitis (EoE); diagnosis  ; treatment  ; monitoring; disease assessment; precision medicine
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Endocrine Malignancies: Current Surgical Therapeutic Approaches: 2nd Edition
edited by , and Marco Bononi
submission deadline 18 Feb 2026 | 4 articles | Viewed by 5131 | Submission Open
Keywords: endocrine malignancies; thyroid cancer; adrenocortical cancer; parathyroid; men
(This special issue belongs to the Section Endocrinology & Metabolism)
Traumatic Brain Injury: Emergency Management, Prevention of Secondary Injury, and Rehabilitation
edited by and Lori Shutter
submission deadline 20 Feb 2026 | 5 articles | Viewed by 18590 | Submission Open
Keywords: traumatic brain injury; neuromonitoring; neurocritical care; neurorehabilitation; secondary injury; outcome; prognostication
(This special issue belongs to the Section Brain Injury)
Sepsis: Current Updates and Perspectives submission deadline 20 Feb 2026 | 8 articles | Viewed by 18586 | Submission Open
Keywords: sepsis biomarkers; diagnostic tools; cytokines; inflammation; infection; antibiotherapy; blood purification; novel therapies
(This special issue belongs to the Section Intensive Care)
Recent Developments in Gynecological Endocrinology submission deadline 20 Feb 2026 | 8 articles | Viewed by 17113 | Submission Open
Keywords: amenorrhea; puberty; PCOS; premature ovarian insufficiency; endometriosis; infertility; pregnancy; hormones; menopause
(This special issue belongs to the Section Obstetrics & Gynecology)
Sexually Transmitted Infections as a Challenge of Modern Society: Old Problems and Modern Solutions
edited by Mauro Zaccarelli and
submission deadline 20 Feb 2026 | 5 articles | Viewed by 15756 | Submission Open
Keywords: sexually transmitted infections (STIs); human papilloma virus (HPV); syphilis; gonorrhea; chlamydia trachomatis; HIV infection; PrEP; chemsex
(This special issue belongs to the Section Infectious Diseases)
Endodontic and Periodontal Medicine: Systemic Implications of Oral Infections submission deadline 20 Feb 2026 | 10 articles | Viewed by 15135 | Submission Open
Keywords: dentistry; endodontics; apical periodontitis; endodontic medicine; periodontal disease; periodontal medicine; pulpitis; systemic diseases; root canal treatment
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Blood Disorders: Diagnosis, Management, and Future Opportunities submission deadline 20 Feb 2026 | 4 articles | Viewed by 13093 | Submission Open
Keywords: blood disorders; biomarkers; personalized medicine; diagnosis; NGS; metabolomics; digital droplet PCR (ddPCR)
(This special issue belongs to the Section Hematology)
Pediatric Critical Care: Clinical Recognition, Management, and Outcomes
edited by Janet Hume
submission deadline 20 Feb 2026 | 6 articles | Viewed by 12807 | Submission Open
Keywords: pediatric critical care medicine; sepsis; pediatric acute respiratory distress syndrome; mechanical ventilation; renal replacement therapy; chronic critical illness; post-intensive care syndrome
(This special issue belongs to the Section Clinical Pediatrics)
Cystic Fibrosis: Diagnosis and Treatment
edited by Corrado Tagliati and Gian Marco Giuseppetti
submission deadline 20 Feb 2026 | 6 articles | Viewed by 12397 | Submission Open
Keywords: cystic fibrosis; diagnosis; treatment; management
(This special issue belongs to the Section Respiratory Medicine)
Preeclampsia and Other Pregnancy Complications: Early Intervention, Diagnosis and Management
edited by , and Mohamed Ahmed Mostafa Aboellail
submission deadline 20 Feb 2026 | 4 articles | Viewed by 9862 | Submission Open
Keywords: preeclampsia; pregnancy complications; early intervention; diagnosis of pregnancy complications; management of pregnancy complications; sexual dysfunctions in pregnancy
(This special issue belongs to the Section Obstetrics & Gynecology)
Orthopedic Surgery: Recent Advances and Prospects
edited by Mitchell K. Ng
submission deadline 20 Feb 2026 | 4 articles | Viewed by 9409 | Submission Open
Keywords: orthopedic surgery; clinical updates; joint reconstruction; spine surgery; trauma; elective surgery; peri-operative management
(This special issue belongs to the Section Orthopedics)
Management of Pituitary Tumors: Current and Future Treatment Options—2nd Edition
edited by
submission deadline 20 Feb 2026 | 6 articles | Viewed by 9115 | Submission Open
Keywords: pituitary; cushing syndrome; acromegaly; prolactinoma; non-functioning pituitary adenoma; hypopituitarism; hypophysitis
(This special issue belongs to the Section Endocrinology & Metabolism)
Neuroendocrine Tumors: Challenges and Future Perspectives (Second Edition) submission deadline 20 Feb 2026 | 5 articles | Viewed by 8942 | Submission Open
Keywords: neuroendocrine tumors; clinical challenges; innovative biomarkers; novel agents; personalized oncology
(This special issue belongs to the Section Oncology)
Targeted Treatment in Chronic Inflammatory Arthritis
edited by , and Simone Perniola
submission deadline 20 Feb 2026 | 4 articles | Viewed by 8126 | Submission Open
Keywords: rheumatoid arthritis; psoriatic arthritis; ankylosing spondylitis; spondyloarthritis; disease-modifying antirheumatic drugs (DMARDs); personalized medicine; immunomodulatory therapies; patient outcomes; combination therapies
(This special issue belongs to the Section Immunology & Rheumatology)
Navigating Pregnancy and Its Complications: Challenges and Innovations in Maternal–Fetal Medicine submission deadline 20 Feb 2026 | 3 articles | Viewed by 8118 | Submission Open
Keywords: pregnancy; obstetrics; diabetes; high risk; preeclampsia; labor; delivery; hypertension; hemorrhage; embryo; screening
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Updates on Hereditary Hemorrhagic Telangiectasia (HHT) and Other Vascular Diseases
edited by Tamás Major
submission deadline 20 Feb 2026 | 5 articles | Viewed by 6114 | Submission Open
Keywords: hereditary hemorrhagic telangiectasia (HHT); arteriovenous malformations; embolization; VEGF; capillary malformation-arteriovenous malformation
(This special issue belongs to the Section Vascular Medicine)
Optimizing Present and Future Therapeutic Choices for Treatment and Management of Chronic Inflammatory Bowel Diseases—2nd Edition
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 5995 | Submission Open
Keywords: Inflammatory Bowel Diseases(IBD); JAK inhibitors; mucosal healing
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Recent Advances in Immunotherapy of Cancer submission deadline 20 Feb 2026 | 3 articles | Viewed by 5507 | Submission Open
Keywords: immunotherapy; immunology; cancer; oncology; tumor immune microenvironment; artificial intelligence; immune-related adverse events
(This special issue belongs to the Section Oncology)
Gastrointestinal Diseases: Clinical Challenges and Management
edited by Anusha Shirwaikar Thomas and
submission deadline 20 Feb 2026 | 3 articles | Viewed by 5480 | Submission Open
Keywords: GI bleed; nutrition; obstructive jaundice; drug-induced liver injury; GI motility; clostridium difficile infection; large bowel obstruction; colon cancer prevention and surveillance
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Novel Therapeutic Targets with Inflammatory Bowel Diseases
edited by Konstantinos H. Katsanos and
submission deadline 20 Feb 2026 | 2 articles | Viewed by 5473 | Submission Open
Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; colorectal; intestinal bowel disease; mucosal im-munology; molecular endoscopy; fibrosis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
The Complex Interplay Between Physical Activity, Sleep, Diet, and Obesity: Clinical Insights for Treatment and Prevention submission deadline 20 Feb 2026 | 5 articles | Viewed by 5376 | Submission Open
Keywords: body mass; body composition; nutrition; sleep patterns; weight management; lifestyle interventions; sedentary behavior; adiposity; obesity prevention; dietary habits
(This special issue belongs to the Section Clinical Rehabilitation)
Non-Invasive Respiratory Support: Current Insights and Future Directions
edited by Giovanni Misseri and
submission deadline 20 Feb 2026 | 3 articles | Viewed by 5239 | Submission Open
Keywords: respiratory failure; high-flow nasal cannula (HFNC); noninvasive ventilation (NIV); noninvasive positive pressure ventilation (NPPV); hypoxia; perioperative care; weaning; ICU; respiratory care; respiratory physiology; pneumology; home-care ventilation; artificial intelligence; personalized medicine
(This special issue belongs to the Section Respiratory Medicine)
Cardiopulmonary Resuscitation in Emergency Care Units submission deadline 20 Feb 2026 | 4 articles | Viewed by 4917 | Submission Open
Keywords: cardiopulmonary resuscitation; emergency care; cardiac arrest; CPR techniques; resuscitation devices; post-resuscitation care; survival outcomes
(This special issue belongs to the Section Emergency Medicine)
Updates on Lumbar Spine Surgery for Degenerative Diseases
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4855 | Submission Open
Keywords: degenerative disease; lumbar spine surgery; fusion; decompressive surgery; sagittal alignment; complications; outcomes
(This special issue belongs to the Section Orthopedics)
Alcohol-Related Liver Disease: Diagnosis, Treatment, and Management submission deadline 20 Feb 2026 | 4 articles | Viewed by 4770 | Submission Open
Keywords: alcohol-related liver disease; gut– liver axis; hepatic fibrosis; liver cirrhosis; micro-RNA; inflammatory pathways; liver transplantation; steatohepatitis; fecal microbiota transplantation in liver cirrhosis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Interstitial Lung Disease: From Diagnosis to Treatment
edited by and Tomohisa Baba
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4662 | Submission Open
Keywords: interstitial pneumonia; diagnosis; virus infection; collagen vascular disease-related interstitial pneumonia; differen-tial diagnosis; lung sounds
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Gastrointestinal Inflammation
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4460 | Submission Open
Keywords: Helicobacter pylori; antibiotic resistance; COVID-19 pandemic; post-COVID era; inflammatory bowel diseases; acute gastrointestinal infections; SARS-COV-2 infection; celiac disease
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
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