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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Research in Radiation Oncology: Current Status and Future Directions

edited by Paolo Borghetti

submission deadline 15 Apr 2026 | 2 articles | Viewed by 5509 | Submission Open

Keywords: radiation oncology; radiobiology; stereotactic body radiotherapy; multidisciplinary team; integrated treatment; predictive and prognostic biomarkers; cancer treatment

(This special issue belongs to the Section Oncology)

Novel Insights into Neonatal Intensive Care

edited by

Vasilios Giapros

and Maria Baltogianni

submission deadline 15 Apr 2026 | 2 articles | Viewed by 3723 | Submission Open

Keywords: neonatology; neonatal intensive care; neonate; sepsis; nutrition; ventilation; hemodynamic; neurodevelopment

(This special issue belongs to the Section Clinical Pediatrics)

Modern Approaches to the Management of Orthopedic Injuries

edited by

Moshe Salai

submission deadline 15 Apr 2026 | 2 articles | Viewed by 3359 | Submission Open

Keywords: orthopedic trauma; surgical integration; trauma management; modern approaches; rehabilitation advances

(This special issue belongs to the Section Orthopedics)

Diagnosis and Treatment of Sjogren’s Syndrome: 2nd Edition

edited by

Yoshiro Horai

submission deadline 15 Apr 2026 | 1 articles | Viewed by 2819 | Submission Open

Keywords: biological agents; JAK inhibitors; magnetic resonance imaging; noncoding RNA; Sjö gren's syndrome; ultrasound

(This special issue belongs to the Section Immunology & Rheumatology)

Clinical Diagnostics and Therapeutic Advances in Pregnancy Complications

edited by

Theresa Reischer

and

Gülen Yerlikaya-Schatten

submission deadline 15 Apr 2026 | 2 articles | Viewed by 1540 | Submission Open

Keywords: prenatal diagnosis; pre-eclampsia; gestational diabetes; pregnancy complications; preterm labor; congenital mal-formations; prenatal genetic testing

(This special issue belongs to the Section Obstetrics & Gynecology)

Oral and Maxillofacial Surgery: Current Trends, Innovations and Techniques

edited by Gabriel Armencea and

Florin Onisor

submission deadline 15 Apr 2026 | Viewed by 1336 | Submission Open

Keywords: maxillofacial; trauma; deformities; cleft lip and palate; OMF surgery; head and neck; head and neck oncology; orthognathic surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Retinal Dystrophies—Structure and Function Relationship

edited by

Katarzyna Nowomiejska

submission deadline 15 Apr 2026 | 1 articles | Viewed by 798 | Submission Open

Keywords: retinal dystrophies; structural changes; functional impairment; in retinal degenerative diseases; retinitis pigmentosa

(This special issue belongs to the Section Ophthalmology)

Retinal Diseases: Emerging Therapies and Vision Rehabilitation

edited by

Hisanori Imai

submission deadline 15 Apr 2026 | 1 articles | Viewed by 771 | Submission Open

Keywords: vitreoretinal disorder; vitrectomy; digital assisted vitrectomy; intraoperative optical coherence tomography; diabetic retinopathy; epiretinal membrane

(This special issue belongs to the Section Ophthalmology)

Nasopharyngeal Carcinoma: Recent Advances in Clinical Diagnosis and Treatment

edited by

Federico Sireci

submission deadline 15 Apr 2026 | 1 articles | Viewed by 604 | Submission Open

Keywords: nasopharyngeal carcinoma; early diagnosis; radiotherapy advances; immunotherapy; targeted therapy; biomarkers; precision medicine; recurrence and metastasis management

(This special issue belongs to the Section Otolaryngology)

Clinical Advances in the Management of Melanoma

edited by

Kelly M. Mahuron

and

Yan Xing

submission deadline 15 Apr 2026 | 1 articles | Viewed by 440 | Submission Open

Keywords: melanoma immunotherapy; targeted therapy; immune checkpoint inhibitors; melanoma subtypes; adjuvant treatment; neoadjuvant treatment; tumor-infiltrating lymphocytes (TILs) therapy; combination therapy; molecular profiling; bi-omarker-driven therapy; clinical decision-making; liquid biopsy

(This special issue belongs to the Section Dermatology)

Advances in Gynecological Diseases (Second Edition)

edited by

Guglielmo Stabile

submission deadline 15 Apr 2026 | 1 articles | Viewed by 327 | Submission Open

Keywords: gynecology; women's health; mini-invasive surgery; laparoscopy; hysteroscopy; diagnostic imaging; gynecological oncology; endometriosis; new therapy; urogynecology; female healthcare

(This special issue belongs to the Section Obstetrics & Gynecology)

Management of Intra-Abdominal Infections: Current Challenges and Perspectives

edited by

Alessandro Pasculli

and Carlo Valicelli

submission deadline 15 Apr 2026 | Viewed by 266 | Submission Open

Keywords: intra-abdominal infection; anastomotic dehiscence; acute cholecystitis; acute appendicitis; acute diverticulitis; infected pancreatic necrosis; secondary peritonitis; tertiary peritonitis; intra-abdominal abscess; peptic ulcer perforation; minimally invasive surgery; surgical endoscopy; antimicrobic stewardship; antibiotic therapy; artificial intelligence

(This special issue belongs to the Section General Surgery)

Orthopedic Surgery: Latest Advances and Future Prospects—2nd Edition

edited by Andrea Marinozzi and

Biagio Zampogna

submission deadline 15 Apr 2026 | 1 articles | Viewed by 188 | Submission Open

Keywords: custom-made; regenerative; prosthetic; noninvasive surgery; robotic surgery; percutaneous surgery; minimally invasive surgery

(This special issue belongs to the Section Orthopedics)

AI-Enhanced Medical Imaging for Cancer Diagnosis

edited by

Aruni Ghose

Sola Adeleke

and

Stergios Boussios

submission deadline 15 Apr 2026 | Viewed by 170 | Submission Open

Keywords: artificial intelligence; imaging; MRI; precise diagnosis; oncology

(This special issue belongs to the Section Oncology)

Innovations in Parkinson’s Disease

edited by

Sneha Mantri

submission deadline 15 Apr 2026 | Viewed by 134 | Submission Open

Keywords: Parkinson’ s disease; parkinsonism; patient-reported outcomes; wearable technology; disease-modifying therapies; non-pharmacological therapies; care delivery; models of care

(This special issue belongs to the Section Clinical Neurology)

Updates and Advances in Aplastic Anemia and Other Bone Marrow Failures

edited by

Alicia Rovo

, Beatrice Drexler and Olaia Naveiras

submission deadline 15 Apr 2026 | Viewed by 100 | Submission Open

Keywords: aplastic anemia; severe aplastic anemia (SAA); bone marrow failures; paroxysmal nocturnal hemoglobinuria (PNH); inherited bone marrow failures

(This special issue belongs to the Section Hematology)

Current and Future Trends in Otorhinolaryngology–Head and Neck Surgery: 2nd Edition

edited by

Konstantinos Chaidas

submission deadline 15 Apr 2026 | Viewed by 95 | Submission Open

Keywords: otorhinolaryngology; head and neck; innovation; diagnosis; treatment; surgery

(This special issue belongs to the Section Otolaryngology)

Cardiac Amyloidosis and Heart Failure: Clinical Pathophysiology, Diagnosis, and Therapeutic Strategies

edited by Ilaria Dentamaro and

Laura Fusini

submission deadline 15 Apr 2026 | Viewed by 90 | Submission Open

Keywords: cardiology; cardiac heart failure; cardiac amyloidosis; cardiac imaging; cardiomyopathy

(This special issue belongs to the Section Cardiology)

Heart Transplantation: Surgery Updates and Complications

edited by Nicola Pradegan

submission deadline 15 Apr 2026 | Viewed by 88 | Submission Open

Keywords: donor heart optimization; antibody-mediated rejection; graft function monitoring; ventricular assist device bridging; post-transplant surveillance

(This special issue belongs to the Section Cardiology)

Prenatal Diagnosis and Intervention: Shaping the Future of Maternal–Fetal Medicine

edited by

Misgav Rottenstreich

submission deadline 15 Apr 2026 | Viewed by 82 | Submission Open

Keywords: diabetes in pregnancy; hypertension in pregnancy; cholestasis in pregnancy; endocrine disorder in pregnancy; sepsis in pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Hepato-Pancreato-Biliary Surgery in the Era of Immunotherapy

edited by Niv Pencovich

submission deadline 15 Apr 2026 | Viewed by 78 | Submission Open

Keywords: hepatobiliary surgery; immunotherapy; pancreatic and liver cancer; conversion surgery; immune checkpoint inhibitors

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advances in Antiplatelet Therapy After Cardiovascular Surgery

edited by

Marek T. Tomala

submission deadline 15 Apr 2026 | Viewed by 75 | Submission Open

Keywords: antiplatelet therapy; cardiac surgery; P2Y12 inhibitors; platelet function testing; dual antiplatelet therapy (DAPT); perioperative management; bleeding risk stratification

(This special issue belongs to the Section Cardiovascular Medicine)

Management of Coronary Syndrome for Better Outcome

edited by

Cristina Madaudo

Vincenzo Sucato

and Antonio Luca Maria Parlati

submission deadline 15 Apr 2026 | Viewed by 65 | Submission Open

Keywords: acute coronary syndrome; chronic coronary syndrome; percutaneous coronary intervention; dual antiplatelet therapy; intravascular imaging; risk stratification; secondary prevention; cardiovascular outcomes; artificial intelligence; digital health

(This special issue belongs to the Section Cardiology)

Most Advanced Therapeutic Agents Redefining Neurological Health

edited by Clarissa Fantin Cavarsan

submission deadline 15 Apr 2026 | Viewed by 64 | Submission Open

Keywords: disease-modifying therapy; biomarker-guided treatment; gene therapy; neuroprotection; clinical trials; neurological disorders; precision neurology

(This special issue belongs to the Section Clinical Neurology)

Arrhythmia and Sudden Cardiac Death: Risk Factors, Prevention, and Management

edited by Jitendra Vohra

submission deadline 15 Apr 2026 | Viewed by 57 | Submission Open

Keywords: sudden cardiac death; arrhythmia; cardiac arrest; cardiopulmonary resuscitation; implantable cardioverter-defibrillators; automated external defibrillators

(This special issue belongs to the Section Cardiology)

New Perspectives on Diagnosis, Prognosis and Treatment of Tricuspid Regurgitation According to Etiology

edited by Sergio Moral

submission deadline 15 Apr 2026 | Viewed by 55 | Submission Open

Keywords: tricuspid regurgitation; transcatheter tricuspid intervention; 3D echocardiography; cardiac magnetic resonance; valve repair techniques

(This special issue belongs to the Section Cardiology)

Pharmacotherapy and Patient Care in Rheumatoid Arthritis

edited by

Ryu Watanabe

submission deadline 15 Apr 2026 | Viewed by 54 | Submission Open

Keywords: rheumatoid arthritis; pharmacotherapy; patient care; biomarkers; treatment outcomes

(This special issue belongs to the Section Immunology & Rheumatology)

The State of the Art in Adjuvant Breast Irradiation: Technical, Clinical, and Genomic Advances in the Adjuvant and Neo-Adjuvant Fields

edited by Grazia Lazzari

submission deadline 15 Apr 2026 | Viewed by 50 | Submission Open

Keywords: radiation oncology; breast cancer therapy; deep inspiration breath hold; DIBH; stereotactic body radiation therapy; SBRT; intraoperative radiation therapy; IORT; prone positioning; protons; hypofractionation

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Cruciate Ligament Injuries in Sport Medicines: Diagnosis, Treatment and Rehabilitation

edited by

Rafal Kamiński

submission deadline 15 Apr 2026 | Viewed by 45 | Submission Open

Keywords: cruciate ligament; sport medicine; trauma; meniscus; knee instability; anterior cruciate ligament reconstruction; posterior cruciate ligament; rehabilitation; return to sport; injury prevention

(This special issue belongs to the Section Sports Medicine)

Periodontology and Dental Implants: State of the Art and Future Perspectives

edited by Magda Mensi and

Davide Farronato

submission deadline 17 Apr 2026 | Viewed by 107 | Submission Open

Keywords: periodontology; dental implants; regenerative dentistry; peri-implant diseases; digital dentistry; implant surface modifications; tissue engineering; oral microbiome; risk assessment; personalized treatment

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Haemodialysis and Peritoneal Dialysis: Current Clinical Practices and Innovations

edited by

Susanne Angermann

submission deadline 17 Apr 2026 | Viewed by 95 | Submission Open

Keywords: haemodialysis; peritoneal dialysis; end-stage kidney disease; chronic kidney disease; nephrology

(This special issue belongs to the Section Nephrology & Urology)

Clinical Management of Corneal Diseases

edited by Hyeck Soo Son

submission deadline 18 Apr 2026 | 2 articles | Viewed by 1304 | Submission Open

Keywords: corneal diseases; keratoconus; corneal dystrophy; corneal ectasia; corneal transplantation; DMEK; DSAEK; kerato-prosthesis; crosslinking; ICRS; CAIRS; Bowman layer transplantation; treatment outcomes; clinical management

(This special issue belongs to the Section Ophthalmology)

Treatment Personalization in Clinical Psychology and Psychotherapy

edited by

Dariusz Krok

submission deadline 20 Apr 2026 | 11 articles | Viewed by 32027 | Submission Open

Keywords: treatment personalization; clinical psychology; psychotherapy; personalized treatment; psychosomatic interventions; coping and personalization

(This special issue belongs to the Section Mental Health)

Metabolic Syndrome and Its Burden on Global Health

edited by Umberto Goglia, Luca Monge,

Elena Succurro

Livia Pisciotta

and

Salvatore De Rosa

submission deadline 20 Apr 2026 | 8 articles | Viewed by 22400 | Submission Open

Keywords: insulin resistance; chronic low-grade inflammation; gut microbiota; energy balance; obesity; hyperlipidemia; metabolic dysfunction-associated steatotic liver (MASLD); type 2 diabetes mellitus; heart failure; diabetic cardiomyopathy; cardio-nephro-metabolic syndrome; metabolic syndrome sex differences; metabolic syndrome and health inequity; metabolic syndrome health-economic burden

(This special issue belongs to the Section Endocrinology & Metabolism)

Clinical Advances in Artificial Intelligence in Urology

edited by

Theodoros Tokas

submission deadline 20 Apr 2026 | 8 articles | Viewed by 15218 | Submission Open

Keywords: artificial intelligence; deep learning; artificial neural networks; computer; AI; machine learning

(This special issue belongs to the Section Nephrology & Urology)

Clinical Highlights in Chronic Obstructive Pulmonary Disease (COPD)

edited by

Richard Zuwallack

and Dimosthenis Lykouras

submission deadline 20 Apr 2026 | 4 articles | Viewed by 11763 | Submission Open

Keywords: COPD treatment; inhalers; patient-reported outcomes; COPD rehabilitation; cardiovascular risk

(This special issue belongs to the Section Respiratory Medicine)

Facial Plastic and Cosmetic Medicine

edited by

Neelam Vashi

submission deadline 20 Apr 2026 | 3 articles | Viewed by 10530 | Submission Open

Keywords: cosmetics; aesthetics; plastic surgery; skin rejuvenation; beauty; procedures

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Current Status, Challenges and Future Directions in Aortic Valve Replacement

edited by Guglielmo Saitto and Giovanni Alfonso Chiariello

submission deadline 20 Apr 2026 | 5 articles | Viewed by 9799 | Submission Open

Keywords: aortic valve; aortic valve replacement; minimally invasive surgery; robotic surgery; TAVI; ross operation; root enlargement techniques; heart team; lifetime management

(This special issue belongs to the Section Cardiology)

New Insights into Physical Therapy

edited by

Patsaki Irini

and

George A. Koumantakis

submission deadline 20 Apr 2026 | 4 articles | Viewed by 9738 | Submission Open

Keywords: physical rehabilitation; new technologies; virtual reality; augmented reality; telerehabilitation; clinical pilates; blood flow restriction; manual therapy; motor imagery; electrophysical modalities; therapeutic exercises; neurology; musculoskeletal; geriatric; respiratory; acute illness; cardiovascular

(This special issue belongs to the Section Sports Medicine)

Clinical Advances in Child Neurology

edited by Claire Marie Rangon and

Debopam Samanta

submission deadline 20 Apr 2026 | 5 articles | Viewed by 8934 | Submission Open

Keywords: non-invasive; invasive; neuromodulation; children; neurodevelopmental disorders; autism spectrum disease; refractory epilepsy; vagus nerve stimulation

(This special issue belongs to the Section Clinical Pediatrics)

Chronic Renal Disease: Diagnosis, Treatment, and Management

edited by

Anna Clementi

submission deadline 20 Apr 2026 | 3 articles | Viewed by 8430 | Submission Open

Keywords: acute kidney injury; chronic kidney disease; cardio– renal syndromes; clinical nephrology; diagnosis and management

(This special issue belongs to the Section Nephrology & Urology)

Evolution of Breast Reconstruction: Current Techniques, Advances and Future Directions

edited by

Dung Nguyen

and Andrea Moreira

submission deadline 20 Apr 2026 | 4 articles | Viewed by 8405 | Submission Open

Keywords: breast reconstruction; microsurgery; robot-assisted surgery; breast neurotization; lymphatic surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Artificial Intelligence and Eye Disease

edited by

Andrzej Grzybowski

Louis Arnould

and

Haoyu Chen

submission deadline 20 Apr 2026 | 6 articles | Viewed by 8064 | Submission Open

Keywords: Artificial Intelligence; machine learning; deep learning; ophthalmology; eye disease; eye disorder

(This special issue belongs to the Section Ophthalmology)

Clinical Advances in Diabetes, Obesity, and Hypertension

edited by

Piotr Matłosz

and

Justyna Wyszyńska

submission deadline 20 Apr 2026 | 5 articles | Viewed by 7788 | Submission Open

Keywords: obesity; hypertension; diabetes; lifestyle; physical activity; risk factors

(This special issue belongs to the Section Endocrinology & Metabolism)

Patient-Oriented Treatments for Heart Failure

edited by Elisa Fabbri

submission deadline 20 Apr 2026 | 4 articles | Viewed by 6507 | Submission Open

Keywords: heart failure; personalized care; patient-centered treatment; aging; comorbidity; multimorbidity; frailty

(This special issue belongs to the Section Cardiology)

Current Treatment and Future Options of Ischemic Stroke

edited by Raluca Elena Sandu and Carmen Valeria Albu

submission deadline 20 Apr 2026 | 2 articles | Viewed by 6413 | Submission Open

Keywords: ischemic stroke; stroke; neuroinflammation; cerebral ischemia; thrombolysis; neuroprotection; rehabilitation strate-gies; stroke biomarkers; extracellular vesicles; stem cell therapy; post-stroke recovery; cerebral ischemia; advanced imaging in stroke; personalized stroke treatment

(This special issue belongs to the Section Clinical Neurology)

Current Progress in Inflammatory Bowel Disease (IBD)

edited by

Dan Lucian Dumitrascu

and Simona Grad

submission deadline 20 Apr 2026 | 5 articles | Viewed by 6167 | Submission Open

Keywords: assessment and diagnosis of IBD; diet and nutrition in IBD; Microbiota and IBD; RCTs in IBD; new therapies in IBD; meta-analyses and systematic reviews in IBD; psychological impact and quality of life in IBD; imaging techniques in IBD; pathogenesis of IBD (including the impact of disrupted barrier function)

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Artificial Intelligence and Deep Learning in Medical Imaging

edited by Eros Montin and Giuseppe Carluccio

submission deadline 20 Apr 2026 | 6 articles | Viewed by 5660 | Submission Open

Keywords: magnetic resonance imaging; radiomics; artificial intelligence (AI); deep learning; clinical and translational medicine; MRI safety; radiogenomics; multiomics

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Advances in Anesthesia and Intensive Care During Perioperative Period

edited by

Philipp Simon

submission deadline 20 Apr 2026 | 3 articles | Viewed by 5560 | Submission Open

Keywords: general anesthesia; intensive care medicine; post intensive care syndrome; perioperative management; fast track; pain management; complications; postoperative outcome; digitalization; big data; AI; closed-loop systems; machine learning; clinical decision support; telemedicine

(This special issue belongs to the Section Intensive Care)

Cardiovascular Risks in Autoimmune and Inflammatory Diseases

edited by

Elena Rezus

and

Ciprian Rezus

submission deadline 20 Apr 2026 | 5 articles | Viewed by 5461 | Submission Open

Keywords: autoimmune diseases; inflammation; cardiovascular risk; atherosclerosis; biological therapy; immunomodulatory therapy; lipid metabolism; cardiovascular risk factors; thrombosis; endothelial dysfunction

(This special issue belongs to the Section Immunology & Rheumatology)

Displaying special issue 1051-1100 on page 22 of 31.

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