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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Research on Synthetic Medicinal Chemistry
edited by Alberto Ongaro
submission deadline 20 Nov 2025 | Viewed by 94 | Submission Open
Keywords: drug development; lead optimization; degraders; PROTACs; bioactive molecules
(This special issue belongs to the Section Molecular Pharmacology)
High-Performance Composites: Molecular Design and Applications in Extreme Environments
edited by Fan Yang
submission deadline 20 Nov 2025 | Viewed by 94 | Submission Open
Keywords: thermal protection materials; mechanical and physical properties; extreme environments; molecular dynamics analysis; composite molecular design; preparation; simulation; and characterization
(This special issue belongs to the Section Materials Science)
Production of Bioactive Compounds by Microbes: Biosynthetic Pathway Elucidation and Metabolic Engineering
edited by , Ziqiao Yuan and Ying Zhang
submission deadline 20 Nov 2025 | Viewed by 94 | Submission Open
Keywords: bioacitve compounds; engineered microbes; biosynthetic pathway; metabolic engineering; synthetic biology; metabolic reprogramming
(This special issue belongs to the Section Molecular Microbiology)
Molecular Basis and Treatment of Creatine Deficiency Syndromes
edited by Andreas Schulze
submission deadline 20 Nov 2025 | Viewed by 93 | Submission Open
Keywords: AGAT; GAMT; creatine transporter; SCL6A8; GATM; creatine deficiency; guanidinoacetate; animal models; cell models
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Role of Nanomaterials in Plant Metabolism
edited by
submission deadline 20 Nov 2025 | Viewed by 90 | Submission Open
Keywords: nanoparticles; nanomaterials; abiotic stress; photosynthesis; chlorophyll fluorescence; signal molecules; antioxidant activity; chlorophyll fluorescence; photosynthetic machinery; reactive oxygen species; thylakoid membranes; signal molecules; physiological and stressful conditions; plant metabolism
(This special issue belongs to the Section Molecular Nanoscience)
Antibacterial Activity of Novel Antimicrobial Agents
edited by Paweł Kowalczyk
submission deadline 20 Nov 2025 | Viewed by 88 | Submission Open
Keywords: novel antimicrobial agents; antibiotic resistance; chemical entities; phage therapy; bacterial pathogens; antimicrobial peptides; resistance mechanisms
(This special issue belongs to the Section Molecular Pharmacology)
Plant Tolerance to Stress
edited by
submission deadline 20 Nov 2025 | Viewed by 17 | Submission Open
Keywords: plant; genetic breeding; biotic stress; abiotic stress; gene regulation
(This special issue belongs to the Section Molecular Plant Sciences)
Nanostructured Formulations in Pharmaceutical, Medical and Cosmetic Applications, 3rd Edition
edited by
submission deadline 21 Nov 2025 | Viewed by 29 | Submission Open
Keywords: surfactants; disperse systems; colloids; nanoemulsions; lipid nanocarriers; polymeric nanocarriers; lyotropic liquid crystals; colloidal stability; drug delivery; self-organization; templating processes; encapsulation/solubilization processes; theranostics; nanohybrids
(This special issue belongs to the Section Macromolecules)
Hallmarks of Cancer: Emerging Insights and Innovations submission deadline 25 Nov 2025 | 2 articles | Viewed by 2768 | Submission Open
Keywords: proliferative signaling; growth suppression evasion; epigenetic reprogramming; immune system evasion; replicative immortality; inflammation and cancer; microbiome and cancer; invasion and metastasis; tumor microenvironment; cellular senescence; genomic instability; metabolic reprogramming; therapeutic resistance; molecular diagnostics; targeted cancer therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms in Organ Transplantation
edited by Hirofumi Hirao
submission deadline 25 Nov 2025 | 3 articles | Viewed by 2512 | Submission Open
Keywords: organ transplantation; cellular-specific response to perioperative stress; cold/warm ischemia; innate/adaptive immunity; microcirculatory disturbance
(This special issue belongs to the Section Molecular Biology)
Pain in Human Health and Disease
edited by
submission deadline 25 Nov 2025 | 1 articles | Viewed by 365 | Submission Open
Keywords: pain signaling; molecular pathways; chronic pain; neuropathic pain; inflammation neuro– immune interactions; epigenetics pharmacogenetics; precion medicine; sleep disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Colorectal Cancer: Molecular and Cellular Basis
edited by Martina Lepore Signorile
submission deadline 25 Nov 2025 | Viewed by 57 | Submission Open
Keywords: colorectal cancer; molecular and cellular biology; tumor initiation; tumor progression; metastasis
(This special issue belongs to the Section Molecular Oncology)
Gene Mutations in Cancer
edited by
submission deadline 25 Nov 2025 | Viewed by 56 | Submission Open
Keywords: oncogenetics; somatic mutations; intratumor mutational heterogeneity; tumor mutational burden; circulating tumor DNA; liquid biopsy
(This special issue belongs to the Section Molecular Genetics and Genomics)
Bioinformatics Analysis of Single Cell and Spatial Mutil-Omics
edited by Fahong Yu
submission deadline 25 Nov 2025 | Viewed by 45 | Submission Open
Keywords: bioinformatics; single-cell omics; spatial multi-omics; matabolomics; genomics; transcriptomics; proteomics; next-generation sequencing techniques
(This special issue belongs to the Section Molecular Informatics)
Oxidative Stress and Disease: Basic and Biochemical Approaches submission deadline 25 Nov 2025 | Viewed by 42 | Submission Open
Keywords: aging; antioxidant mechanisms; cancer; cytokines; enzymatic pathways; inflammatory processes; oxidative stress; reactive oxygen species (ROS)
(This special issue belongs to the Section Molecular Biology)
T Cell Therapy in Cancer: Molecular Perspectives
edited by Alessio Ottaviani
submission deadline 25 Nov 2025 | Viewed by 26 | Submission Open
Keywords: cancer; immunotherapy; gene therapy; chimeric antigen receptor; tumor-infiltrating lymphocytes; T-reg; gamma delta (γ δ ) T cells; cytokine release syndrome; allogenic transplantation
(This special issue belongs to the Section Molecular Oncology)
Circulating Tumor Cells in Oncology: From Liquid Biopsy to Clinical Decision-Making submission deadline 25 Nov 2025 | Viewed by 21 | Submission Open
Keywords: circulating tumor cells (CTCs); liquid biopsy; cancer biomarkers; precision oncology; metastasis; cancer diagnostics; cancer prognosis; CTC enrichment; CTC isolation techniques; single-cell analysis; tumor microenvironment; CTC culture; immune surveillance; blood-based biomarkers; molecular profiling; CTC-derived cell lines; treatment resistance; personalized cancer therapy; cell reprogramming; anti-tumor immunity
(This special issue belongs to the Section Molecular Oncology)
Synthesis, Modification, and Functional Characterization of Advanced Biomaterials for Bone Tissue Engineering
edited by
submission deadline 25 Nov 2025 | Viewed by 20 | Submission Open
Keywords: material functionalization; bioactive materials; antimicrobial; antibiofilm; coatings; scaffolds; bone cements; metal nanoparticles; controlled release; biocompatibility
(This special issue belongs to the Section Materials Science)
Signaling Molecules in Neurological Health and Disease
edited by Venkat Venkataraman
submission deadline 25 Nov 2025 | Viewed by 6 | Submission Open
Keywords: microglia; neuroinflammation; gut– brain axis; neurodegenerative diseases; neuroimmune interactions
(This special issue belongs to the Section Molecular Neurobiology)
Heavy Metal and Fluoride Stress: Toxicity and Tolerance Mechanisms in Plants
edited by
submission deadline 29 Nov 2025 | Viewed by 71 | Submission Open
Keywords: heavy metal toxicity; fluoride stress; stress tolerance mechanisms; phytoremediation; oxidative stress response
(This special issue belongs to the Section Molecular Plant Sciences)
Autoimmune Disorders: Molecular Mechanisms and Therapeutic Strategies submission deadline 29 Nov 2025 | Viewed by 50 | Submission Open
Keywords: molecular mechanisms; immune signaling pathways; targeted therapies; biomarkers; autoimmune pathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Male Infertility and Fertility submission deadline 29 Nov 2025 | Viewed by 41 | Submission Open
Keywords: male infertility; infertility treatment; omics approaches; proteomics; metabolomics; lipidomics; mass spectrometry; signaling pathways; biomarker discovery; reproductive medicine; precision medicine; diagnostic tools
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapies of Pancreatic Cancer: 2nd Edition submission deadline 30 Nov 2025 | 5 articles | Viewed by 8260 | Submission Open
Keywords: pancreatic cancer; metabolism; cellular plasticity; tumor microenvironment; target therapy
(This special issue belongs to the Section Molecular Oncology)
Advances in Cardiac Disease
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 3040 | Submission Open
Keywords: innovative cardiac research; multidisciplinary cardiovascular approaches; advances in cardio-vascular diagnosis; novel cardiac therapies; therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cardiovascular Diseases: Aging and Other Risk Factors
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2941 | Submission Open
Keywords: aging; hypertension; endothelium; vascular smooth muscle cells; pulmonary hypertension; atherosclerosis; hyperlipidemia
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Molecular Pathways in Oncology, 3rd Edition
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2477 | Submission Open
Keywords: molecular pathway involved in tumorigenesis; cancer therapy; targeted therapy; anticancer drugs; brain cancer; oral cancer; gastrointestinal cancer
(This special issue belongs to the Section Molecular Oncology)
Genetic Considerations in the Evolving Treatment Landscape of Hormone-Sensitive and Hormone-Resistant Prostate Cancer
edited by
submission deadline 30 Nov 2025 | Viewed by 272 | Submission Open
Keywords: prostate cancer; hormone-sensitive prostate cancer; HSPC; hormone-resistant prostate cancer; HRPC; metastasis; androgen deprivation therapy; docetaxel; androgen receptor axis-targeted therapy agents; ARAT; abiraterone; enzalutamide; apalutamide; talazoparib; genetic; biomarker; liquid biopsy
(This special issue belongs to the Section Molecular Oncology)
Latest Insights into Glycobiology submission deadline 30 Nov 2025 | Viewed by 244 | Submission Open
Keywords: glycosylation; biomarkers; separation techniques; mass spectrometry; multivariate data analysis
(This special issue belongs to the Section Molecular Biology)
The Innate Immune System in Renal Diseases
edited by
submission deadline 30 Nov 2025 | Viewed by 117 | Submission Open
Keywords: innate immune system; acquired immunity; complement system; dendritic cells; monocyte/macrophages (Mϕ); polymorphonuclear leukocytes; NK/NKT cells; innate lymphoid cells (ILCs); AKI; CKD
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomaterials for Bone Treatment, Replacement and Regeneration: Focus on Regeneration and Inflammation
edited by
submission deadline 30 Nov 2025 | Viewed by 63 | Submission Open
Keywords: biomaterials  ; bone substitute  ; inflammation  ; foreign body response  ; bone regeneration
(This special issue belongs to the Section Materials Science)
Cellular and Molecular Mechanisms of Blood–Brain Barrier (BBB) Dysfunction and Dementia
edited by Mark Slevin
submission deadline 30 Nov 2025 | Viewed by 51 | Submission Open
Keywords: blood– brain barrier; Alzheimer’ s disease; endothelial dysfunction; amyloid beta; tau; neuroinflammation; oxidative stress; aging; gut– brain axis; therapeutic strategies
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms of HIV Infection, Pathogenesis and Persistence
edited by and Inês Bártolo
submission deadline 30 Nov 2025 | Viewed by 47 | Submission Open
Keywords: HIV pathogenesis; molecular virology; antiretroviral therapy; virus– host interactions; HIV eradication strategies
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms Governing Lipid Metabolism in Health and Disease submission deadline 30 Nov 2025 | Viewed by 41 | Submission Open
Keywords: lipid metabolism; energy metabolism; obesity; metabolic syndrome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insight into Nematodes Management
edited by
submission deadline 30 Nov 2025 | Viewed by 38 | Submission Open
Keywords: biological control; micro-organisms; molecular identification; biodiversity; climatic changes; soil nema-todes; cultural practices; host plant resistance; anaerobic soil disinfection; biofumigation
(This special issue belongs to the Section Molecular Biology)
Structural Codes of Sphingolipids and Their Involvement in Diseases submission deadline 30 Nov 2025 | Viewed by 33 | Submission Open
Keywords: sphingolipids; sphingolipid hydrophilic head; sphingolipid hydrophobic tail; sphingolipid signalling; sphingolipid diseases
(This special issue belongs to the Section Biochemistry)
Molecular Advances in Pediatric Neuromuscular Disorders
edited by
submission deadline 30 Nov 2025 | Viewed by 33 | Submission Open
Keywords: pediatric neuromuscular disorders; gene therapy; biomarkers; molecular pathophysiology; muscular dystrophy; motor neuron disease; translational medicine; neuromuscular therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Lipopolysaccharides submission deadline 30 Nov 2025 | Viewed by 25 | Submission Open
Keywords: LPS structural diversity; lipid A; amino arabinose and phosphoethanolamine; TLR4; antibiotic resistance; Lpt transport system; phospholipids and fatty acids; cell envelope stress; lipid A acyltransferases
(This special issue belongs to the Section Molecular Biology)
Cancer-Driving Molecules: From Molecular Mechanisms to Novel Therapeutics
edited by
submission deadline 30 Nov 2025 | Viewed by 23 | Submission Open
Keywords: cancer; mechanism of action; tumor microenvironment; immune system; DNA/RNA/protein; small-molecule probes; activation/inhibition; biological activity
(This special issue belongs to the Section Molecular Oncology)
DNA Repair, Genome Stability and Diseases
edited by Melike Caglayan
submission deadline 30 Nov 2025 | Viewed by 20 | Submission Open
Keywords: DNA damage; DNA repair; genomic stability; targeted therapy; biomarkers
(This special issue belongs to the Section Molecular Genetics and Genomics)
ErbB Family of Receptor Tyrosine Kinases in Cancer and Drug Therapy
edited by Ilaria Marrocco and
submission deadline 30 Nov 2025 | Viewed by 19 | Submission Open
Keywords: ErbB; RTKs; EGFR; HER2; HER3; cancer; targeted therapies; drug resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Glycobiology: The New Discoveries, Approaches, and Technical Developments: 2nd Edition
edited by Sanja Dabelić
submission deadline 30 Nov 2025 | Viewed by 18 | Submission Open
Keywords: glycans; lectins; glycoconjugates; glycosylation; genetic disorders of glycosylation; glycomics and glycoproteomics
(This special issue belongs to the Section Macromolecules)
Hormonal Regulatory Networks in Aging, Cancers, Alzheimer’s Disease, and Therapeutics
edited by
submission deadline 30 Nov 2025 | Viewed by 15 | Submission Open
Keywords: hormonal imbalance and aging; endocrinology; physiology and pathophysiology; steroidogenesis; sex hormones and neurosteroids; age-related complications and diseases; tumorigenesis; hormone-dependent cancers; neurodegenrative diseases; Alzheimer’ s disease; therapeutics; healthy aging
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Non-Coding RNAs as Key Regulators in Human Disease Processes
edited by
submission deadline 30 Nov 2025 | Viewed by 15 | Submission Open
Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; therapeutic targets; molecular mechanisms; RNA-based therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Canonical and Noncanonical Inflammasomes in Inflammation and Diseases
edited by
submission deadline 30 Nov 2025 | Viewed by 14 | Submission Open
Keywords: canonical; noncanonical; inflammasome; inflammation; human diseases; anti-inflammatory therapeutics
(This special issue belongs to the Section Molecular Immunology)
Advances in Targeted Therapies and Immunometabolic Pathways in Cancer
edited by Medhi Wangpaichitr
submission deadline 30 Nov 2025 | Viewed by 11 | Submission Open
Keywords: immunotherapy; targeted therapy; tumor metabolism pathway; tumor microenvironment; immune checkpoint blockade; immune evasion; glucose/amino acids/lipid metabolism
(This special issue belongs to the Section Molecular Immunology)
Molecular Perspectives in Tissue Engineering and Regenerative Medicine
edited by
submission deadline 30 Nov 2025 | Viewed by 9 | Submission Open
Keywords: 3D scaffolds; personalized regenerative therapies; tissue engineering; stem cells; bone regeneration; regenerative biomarkers; cell–scaffold interactions; nanomaterials
(This special issue belongs to the Section Molecular Biology)
The Current Landscape of Microglia-Glioma Research: From Basic Science to Therapeutic Potential submission deadline 1 Dec 2025 | Viewed by 298 | Submission Open
Keywords: microglia; glioma; tumor associated macrophages; immunosuppression; epigenetics
(This special issue belongs to the Section Molecular Neurobiology)
Gene Editing for Cereal Crops
edited by
submission deadline 1 Dec 2025 | Viewed by 63 | Submission Open
Keywords: gene-editing techniques; novel germplasm; quality; nutrition; agronomic traits
(This special issue belongs to the Section Molecular Plant Sciences)
Long-COVID and Its Complications
edited by
submission deadline 4 Dec 2025 | 4 articles | Viewed by 20469 | Submission Open
Keywords: acquired immune deficiency; auto-immunity; blood– brain barrier dysfunction; complication; COVID-19; gut microbiome; hypothalamic– pituitary– adrenal axis; immune dysfunction; long COVID; multisystem dysfunction; neurological complications; SARS-CoV-2; systemic inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biology of Oral Cancer
edited by Rafał Pęksa
submission deadline 10 Dec 2025 | Viewed by 50 | Submission Open
Keywords: oral cancer; molecular mechanisms; biomarkers; tumor microenvironment; therapy resistance; precision medicine; carcinogenesis; oral squamous cell carcinoma; epigenetics; microbiome; immunotherapy; liquid biopsy
(This special issue belongs to the Section Molecular Oncology)
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