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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Therapeutic Strategies Targeting Cancer Stem Cells
edited by Luciano Vellón
submission deadline 28 May 2026 | Viewed by 274 | Submission Open
Keywords: cancer stem cells; machine learning; deep learning; therapeutic response; molecular markers; cancer
(This special issue belongs to the Section Molecular Oncology)
Recent Advances in Iron Metabolism, Ferritin and Hepcidin Research: 3rd Edition
edited by
submission deadline 30 May 2026 | 5 articles | Viewed by 10613 | Submission Open
Keywords: iron; hepcidin; ferroportin; ferritin; regulation; anemia; therapies; cell signaling; inflammation; disorders
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
The Role of Glycans in Immune Regulation
edited by Senlian Hong
submission deadline 30 May 2026 | 2 articles | Viewed by 9218 | Submission Open
Keywords: glycoimmunology; glycotherapy; vaccines; glycan synthesis; immune tolerance
(This special issue belongs to the Section Molecular Immunology)
Innovative Molecular Target and Therapeutic Approaches in Fatty Liver Disease
edited by
submission deadline 30 May 2026 | 1 articles | Viewed by 8179 | Submission Open
Keywords: liver; fatty liver disease; steatosis; rectors; ARA; THR-Beta; IL-22; glucagon; CRISPR-Case9; randomized clinical trials
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cytokines and Inflammatory Diseases
edited by
submission deadline 30 May 2026 | 3 articles | Viewed by 3040 | Submission Open
Keywords: inflammation; cytokines; interleukin-6; immune diseases; immune signaling; autoimmunity; brain inflammation
(This special issue belongs to the Section Molecular Immunology)
Oral Cancer: From Molecular Mechanisms to Therapeutics
edited by Diana Russo
submission deadline 30 May 2026 | 2 articles | Viewed by 1869 | Submission Open
Keywords: oral cancer; molecular mechanisms; carcinogenesis; therapeutic strategies; biomarkers; immunotherapy; tumor microenvironment; drug resistance; precision medicine; head and neck oncology
(This special issue belongs to the Section Molecular Oncology)
Antimicrobial Materials: Novel Studies and Related Applications
edited by
submission deadline 30 May 2026 | 1 articles | Viewed by 1635 | Submission Open
Keywords: antimicrobial materials; functional materials; composite materials; contamination; green materials; green technologies; metallic materials; drug resistance; environmental safety; biocompatibility; biodegradability
(This special issue belongs to the Section Materials Science)
Mitochondrial Metabolism in Human Diseases
edited by Neelanjan Vishnu
submission deadline 30 May 2026 | 2 articles | Viewed by 1152 | Submission Open
Keywords: mitochondrial function; pathophysiology; cellular processes; disease development
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Design, Synthesis, and Biological Evaluation of Novel Bioactive Compounds submission deadline 30 May 2026 | 1 articles | Viewed by 1108 | Submission Open
Keywords: drug design; organic compounds; heterocyclic compounds; synthetic methodologies; medicinal chemistry; bioactive molecules; pharmaceutical applications; structure– activity relationships (SARs); organic synthesis; natural product
(This special issue belongs to the Section Molecular Pharmacology)
Recent Advances in Gastrointestinal Tract Oncology: Pathology, Diagnostics and Therapy (Second Edition)
edited by
submission deadline 30 May 2026 | 1 articles | Viewed by 1102 | Submission Open
Keywords: gastrointestinal cancer; esophageal cancer; gastric (stomach) cancer; colorectal cancer; liver cancer; pancreatic cancer; gallbladder and biliary tract cancer; genetic alterations; molecular subtyping; tumor microenvironment; innovative therapies; targeted therapies; tumor biomarkers
(This special issue belongs to the Section Molecular Oncology)
The Application of Biomaterials in Bone Tissue Repair and Regeneration, 2nd Edition
edited by
submission deadline 30 May 2026 | 1 articles | Viewed by 1093 | Submission Open
Keywords: allograft; autograft; autologous bone; bone; graft materials; mineral substitutes; regeneration
(This special issue belongs to the Section Materials Science)
Oral Diseases and Oral Soft Tissue Repair
edited by Diana Russo
submission deadline 30 May 2026 | 1 articles | Viewed by 871 | Submission Open
Keywords: oral medicine; tissue regeneration; photobiomodulation; periodontology; implant dentistry
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Evolution of the Vertebrate Immune System
edited by
submission deadline 30 May 2026 | Viewed by 654 | Submission Open
Keywords: immune system; molecular evolution; V (D) J recombination; RAG transposon; comparative genomics
(This special issue belongs to the Section Molecular Biology)
The Role of Medicinal Plants in Health and Diseases
edited by
submission deadline 30 May 2026 | 1 articles | Viewed by 599 | Submission Open
Keywords: medicinal plants; phytochemicals; natural products; pharmacological activity; herbal medicine; drug discovery; traditional medicine; therapeutic potential
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Atomic-Scale Design of Li-Ion Battery Materials
edited by
submission deadline 30 May 2026 | Viewed by 491 | Submission Open
Keywords: lithium-ion batteries; atomic-scale design; electrode– electrolyte interface; electrolyte engineering; defect chemistry; solid-state batteries
(This special issue belongs to the Section Materials Science)
Retinal Degeneration: From Pathophysiology to Therapeutic Approaches—4th Edition
edited by
submission deadline 30 May 2026 | 1 articles | Viewed by 428 | Submission Open
Keywords: hereditary retinal disease; retinal inflammation; retinal gene augmentation; editing; optogenetics and splice modulation therapy; natural history studies of the retina; human iPSC-derived retinal organoids and retinal pigment epithelium; retinal iPSC-derived cell therapy; retinal pathology; pre- and clinical gene therapy; animal models for retinal dystrophy; retinal imaging; retina-on-a-chip
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Heavy Metal and Fluoride Stress: Toxicity and Tolerance Mechanisms in Plants
edited by
submission deadline 30 May 2026 | Viewed by 414 | Submission Open
Keywords: heavy metal toxicity; fluoride stress; stress tolerance mechanisms; phytoremediation; oxidative stress response
(This special issue belongs to the Section Molecular Plant Sciences)
Unraveling Immunometabolism in Sepsis: From Cellular Reprogramming to Therapeutic Targets
edited by
submission deadline 30 May 2026 | Viewed by 405 | Submission Open
Keywords: sepsis; immunometabolism; metabolic reprogramming; cellular bioenergetics; innate and adaptive immunity; mitochondrial dysfunction; inflammatory signaling; metabolic biomarkers; therapeutic modulation; host– pathogen interactions
(This special issue belongs to the Section Molecular Immunology)
Atherosclerosis: From Molecular Biology to Therapeutic Perspective: 7th Edition submission deadline 30 May 2026 | Viewed by 296 | Submission Open
Keywords: atherosclerosis; vascular smooth muscle cells; inflammation; endothelium; cell senescence; apoptosis; lipid metabolism; oxidative stress; nitric oxide; exosomes; vascular calcification; cytokines; growth factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Extracellular Matrix Signalling in Health and Disease
edited by
submission deadline 30 May 2026 | Viewed by 253 | Submission Open
Keywords: extracellular; matrix; mechano-transduction; biochemical signalling; cell– matrix interactions; outside-in signalling; matrix remodelling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Progress in Regenerative Therapy Using Blood-Derived Biomaterials: 2nd Edition
edited by , and Tomoharu Mochizuki
submission deadline 30 May 2026 | Viewed by 248 | Submission Open
Keywords: blood-derived biomaterial; platelet-rich plasma; autologous protein solution; mechanism; platelet; coagulation
(This special issue belongs to the Section Materials Science)
Design and Application of Biocatalysts: Emerging Advances in Enzyme Technology submission deadline 30 May 2026 | Viewed by 234 | Submission Open
Keywords: biocatalysis; enzyme engineering; green chemistry; directed evolution; computational design; industrial enzymes; nano-biocatalysts
(This special issue belongs to the Section Biochemistry)
Oxidative Stress and the Kidney: From Physiological Homeostasis to Pathophysiology and Nutraceutical Interventions submission deadline 30 May 2026 | Viewed by 228 | Submission Open
Keywords: oxidative stress; nutraceuticals; CVD risk; CKD; antioxidant
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Engineering Cell-Derived Nanostructures for Therapeutic Delivery
edited by
submission deadline 30 May 2026 | Viewed by 219 | Submission Open
Keywords: extracellular vesicles (EVs); cell membrane-coated nanoparticles; plant-derived nanostructures (PDNSs); bacterial extracellular vesicles (bEVs); drug delivery; nanomedicine; nano-biointerfaces; bioinspired engineering; biomanufacturing; translational nanotechnology
(This special issue belongs to the Section Molecular Nanoscience)
Natural and Synthetic Compounds for Management, Prevention and Treatment of Obesity, 3rd Edition submission deadline 31 May 2026 | 6 articles | Viewed by 32055 | Submission Open
Keywords: obesity; adipokines; obesogens; genetic predisposition; natural/synthetic compounds; cardiovascular disorders; type II diabetes; non-alcoholic fatty liver disease; cancer
(This special issue belongs to the Section Molecular Pharmacology)
State-of-the-Art Molecular Oncology in Brazil, 3rd Edition submission deadline 31 May 2026 | 7 articles | Viewed by 19614 | Submission Open
Keywords: apoptosis; autophagy; calcium; cancer; cell death; chemotherapy; metabolism; mitochondria; drug resistance; oxidative stress
(This special issue belongs to the Section Molecular Oncology)
Herpes Simplex Virus: Immunity, Pathogenicity, Immune Escape Mechanisms, and Antiviral Strategies submission deadline 31 May 2026 | 2 articles | Viewed by 16587 | Submission Open
Keywords: herpes simplex virus (HSV); latency; immune evasion; tegument proteins; epigenetic mechanisms; viral pathogenesis; antiviral strategies; molecular mechanisms; therapeutic interventions
(This special issue belongs to the Section Molecular Immunology)
Molecular and Translational Research on Bone Tumors, 2nd Edition submission deadline 31 May 2026 | 2 articles | Viewed by 14884 | Submission Open
Keywords: primary bone tumours; metastatic bone tumour; therapy; biomarkers; epigenetic factors; immune-oncology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Therapeutic Targets for Neuroinflammation and Neurodegeneration
edited by Muhammad Sohail Khan and
submission deadline 31 May 2026 | 5 articles | Viewed by 14492 | Submission Open
Keywords: neurodegenerative diseases; inflammatory response; nervous system; neuroinflammations
(This special issue belongs to the Section Molecular Neurobiology)
Selected Papers from the 5th International Symposium on Frontiers in Molecular Science (ISFMS)
edited by , , , Atsushi Shiozaki and Akiyuki Taruno
submission deadline 31 May 2026 | 9 articles | Viewed by 11639 | Submission Open
Keywords: protein structure and function; multidomain proteins; drug design and drug resistance; enzymes; molecular biology of galectins; glycobiophysics; NMR spectroscopy; specific sensory systems; brain and systemic function
(This special issue belongs to the Section Biochemistry)
The Role of Epigenetics in Genome Maintenance and Its Relationship to Organismal Aging and Age-Related Diseases
edited by Berta Vázquez and Gerardo Ferrer
submission deadline 31 May 2026 | 4 articles | Viewed by 8279 | Submission Open
Keywords: chromatin; DNA damage; DNA repair; gene transcription; DNA replication; chromosome segregation; genome integrity; chromosome organization
(This special issue belongs to the Section Molecular Genetics and Genomics)
New Insights into Anticancer Strategies
edited by
submission deadline 31 May 2026 | 3 articles | Viewed by 7170 | Submission Open
Keywords: novel targeted therapy; personalized medicine; nanotechnology; AI and machine learning; combination therapy
(This special issue belongs to the Section Molecular Oncology)
Artificial Intelligence: Applications in the Field of Immune-Mediated Inflammatory Diseases and Onco-Hematology submission deadline 31 May 2026 | 1 articles | Viewed by 3806 | Submission Open
Keywords: artificial intelligence; machine learning; immune-mediated diseases; cancers; hematological ma-lignancies
(This special issue belongs to the Section Molecular Immunology)
Advances in Molecular Pathology and Treatment of Breast Cancer
edited by
submission deadline 31 May 2026 | 2 articles | Viewed by 3707 | Submission Open
Keywords: breast cancer; molecular pathology; precision medicine; antibody-drug conjugates (ADCs); circulating tumor DNA (ctDNA); targeted therapy; immunotherapy; treatment resistance; oligometastatic disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring Abiotic Stress in Plants: Mechanisms, Adaptations, and Mitigation Strategies (2nd Edition)
edited by
submission deadline 31 May 2026 | 3 articles | Viewed by 3356 | Submission Open
Keywords: abiotic stress; plant physiology; stress tolerance; crop resilience; molecular mechanisms; biotechnological interventions
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Pulmonary Hypertension and Interstitial Lung Diseases: Mechanisms and Treatments submission deadline 31 May 2026 | 2 articles | Viewed by 3215 | Submission Open
Keywords: pulmonary hypertension; interstitial lung disease; lung fibrosis; pulmonary hemodynamics; pulmonary function testing; pathogenesis; prognosis; survival; treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in the Pharmacology of Depression and Mood Disorders
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 2422 | Submission Open
Keywords: new antidepressants; rapid antidepressant action; ketamine in depression; glutamatergic antidepressants; psychedelics in depression; 5-HT receptors as targets for antidepressant research; neu-roplasticity and antidepressant action
(This special issue belongs to the Section Molecular Pharmacology)
Emerging Biomarkers in Cardiovascular Risk Assessment and Myocardial Injury
edited by Beatriz Martín-Carro
submission deadline 31 May 2026 | 3 articles | Viewed by 2003 | Submission Open
Keywords: cardiovascular disease; myocardial injury; heart failure; biomarkers; risk stratification
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Pathogenesis, Biomarkers, and Therapeutic Development in Huntington’s Disease
edited by Jesús Pérez-Pérez
submission deadline 31 May 2026 | 1 articles | Viewed by 1334 | Submission Open
Keywords: Huntington’ s disease; somatic instability; genetic modifiers; HD RNA biology; mutant huntingtin; molecular pathogenesis; biomarkers; neurobiology of chorea; cognition and psychiatric disturbances; HTT-lowering therapies; gene therapy
(This special issue belongs to the Section Molecular Neurobiology)
Current Advances and Perspectives in Microbial Genetics and Genomics—2nd Edition
edited by and Lucila Saavedra
submission deadline 31 May 2026 | 2 articles | Viewed by 1170 | Submission Open
Keywords: microbial genetics; genomics and metagenomics; yeasts; gene regulation; microbe– host interactions; adaptation and resistance mechanisms; microbial metabolism
(This special issue belongs to the Section Molecular Microbiology)
Advances in Cancer Epigenetics for Precision Medicine submission deadline 31 May 2026 | 1 articles | Viewed by 989 | Submission Open
Keywords: cancer epigenetics; DNA methylation; precision medicine; cancer biomarker; therapeutic target; epidrugs
(This special issue belongs to the Section Molecular Oncology)
Genetic Variations in Human Diseases: 3rd Edition
edited by
submission deadline 31 May 2026 | 2 articles | Viewed by 909 | Submission Open
Keywords: genetic polymorphism; gene– gene interaction; gene– environment interaction; monogenic disorder; mutation phenotype; quantitative trait locus; family-based study; cohort study; association study
(This special issue belongs to the Section Molecular Genetics and Genomics)
Drosophila: A Versatile Model in Biology and Medicine—3rd Edition submission deadline 31 May 2026 | 2 articles | Viewed by 893 | Submission Open
Keywords: model organism; human disease; inherited disease; cancer; neurodegeneration; rare disease; genetics
(This special issue belongs to the Section Molecular Biology)
Molecular and Cellular Mechanisms of Myocardial Disease submission deadline 31 May 2026 | 2 articles | Viewed by 875 | Submission Open
Keywords: cardiac muscle; calcium; sarcomere; troponin; desmossomal complex; hypertrophic cardiomyopathy; dilated cardiomyopathy; arrhythmogenic cardiomyopathy; mitochondria; calmodulin
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Diversity in Structure, Function, and Regulation of Calcium-Permeable Channels
edited by
submission deadline 31 May 2026 | Viewed by 793 | Submission Open
Keywords: calcium-permeable channels in health and disease; calcium-permeable channels in calcium cycling; TRP channels; voltage-gated calcium channels; STIM / Orai complexes; intracellular IP3 calcium channels; intracellular RyR calcium channels; posttranslational calcium channel modifications; calcium-permeable channel inhibitors; calcium-permeable channel biophysics; calcium-permeable channel evolution
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioinformatics Study in Human Diseases: Integration of Omics Data for Personalized Medicine (Third Edition)
edited by
submission deadline 31 May 2026 | 1 articles | Viewed by 752 | Submission Open
Keywords: cancers; ageing-related diseases; bioinformatics; multi-omics; pharmacogenetics; deep learning; evolutionary learning; diagnosis; prognosis; companion biomarker; drug screening; mechanism dissection
(This special issue belongs to the Section Molecular Informatics)
Cardiometabolic Disease: Molecular Biomarkers and Treatment Strategies
edited by Mehrnaz Abbasi
submission deadline 31 May 2026 | 1 articles | Viewed by 594 | Submission Open
Keywords: cardiometabolic diseases; molecular biomarkers; omics technologies; personalized medicine; early detection; machine learning; disease progression; metabolic pathways; transcriptomics; genomic profiling; bioinformatics; therapeutic targets; metabolic dysregulation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Future of Drug Discovery and Development, 2nd Edition submission deadline 31 May 2026 | Viewed by 592 | Submission Open
Keywords: drug discovery; drug development; biotechnology; target identification; target validation; regulatory affairs; regulatory sciences; drug commercialization; pharmaceutical market access; drug screening; novel nonclinical models/approaches; advanced manufacturing; continuous manufacturing; process analytical technology; adaptive clinical trials; in silico laboratory and clinical development; rolling submissions; accelerated approvals; real-world evidence
(This special issue belongs to the Section Molecular Pharmacology)
Neurological Mechanisms of Action of Natural Products
edited by Damião Pergentino De Sousa
submission deadline 31 May 2026 | 1 articles | Viewed by 433 | Submission Open
Keywords: Alzheimer's disease; Parkinson's disease; epilepsy; dementia; pain; essential oils; medicinal plants; alkaloids; flavonoids; natural products
(This special issue belongs to the Section Molecular Neurobiology)
Cellular and Molecular Mechanisms of Neuroinflammation
edited by
submission deadline 31 May 2026 | Viewed by 328 | Submission Open
Keywords: neuroinflammation; astrocytes; microglia; CNS; cytokines; brain; diseases; immune response
(This special issue belongs to the Section Molecular Neurobiology)
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