Neurological Mechanisms of Action of Natural Products
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 May 2026
Special Issue Editor
Interests: drug delivery; medicinal chemistry; natural products
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Central nervous system (CNS) diseases have a high incidence in the world population, especially in older age groups, with the occurrence of neurological disorders such as Alzheimer's disease and Parkinson's disease. In some cases, CNS diseases severely compromise quality of life, resulting in global disability. It is estimated that more than 3 billion people are affected by these diseases, including other dementias, cerebrovascular accidents (CVAs), migraines, and cancers of the nervous system. Effective pharmacological approaches to control symptoms, such as seizures, memory loss, and pain associated with a neurological disorder, are commonly required. In this context, natural products are important sources of neuroactive substances that can serve as new therapeutic options. Many CNS-active drugs and substances belong to natural product classes and act via several mechanisms of action, such as blocking sodium and calcium channels, and enhancing the inhibitory effects of the neurotransmitter GABA, monoamine oxidase B, and catechol-O-methyltransferase. Therefore, in this Special Issue, we invite researchers to discuss the mechanisms of action of natural substances with potential applications in the treatment of neurological disorders.
Prof. Dr. Damião Pergentino De Sousa
Guest Editor
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Keywords
- Alzheimer's disease
- Parkinson's disease
- epilepsy
- dementia
- pain
- essential oils
- medicinal plants
- alkaloids
- flavonoids
- natural products
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