Retinal Degeneration: From Pathophysiology to Therapeutic Approaches—4th Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 May 2026
Special Issue Editor
Interests: retinal degeneration; AAV gene therapy; crumbs homologue 1; CRB1; scRNAseq
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Loss of vision due to retinal degeneration can have monogenic or multifactorial causes. There is an urgent need for cures, treatments, and prevention methods for children and adults affected by retinitis pigmentosa, age-related macular degeneration, Usher syndrome, and other retinal degenerative diseases. The first retinal gene therapy medicine has recently been approved by regulatory agencies, and other clinical studies are ongoing, but many retinal disease genes still lack medicine. The retina is easily accessible through image-guided surgical intervention, including gene therapy and the transplantation of retinal cells. Neural retina and retinal pigment epithelium (RPE) can be generated from induced pluripotent stem cells (hiPSC) and used for pre-clinical studies.
This Special Issue of the International Journal of Molecular Sciences entitled “Retinal Degeneration: From Pathophysiology to Therapeutic Approaches—4th Edition” will focus on recent insights in this field. Studies focusing on new insights into hereditary disease, human and animal retinal pathology due to gene mutations, retinal inflammation, retinal gene therapy, and hiPSC-derived neural retina and RPE, as well as submissions focusing on natural history studies on patients, pre-clinical and clinical gene therapy, animal models for hereditary retinal dystrophy, and retinal imaging are welcome. According to the aims and scope of IJMS, each manuscript needs to include basic studies in biochemistry, molecular biology, or molecular medicine.
Dr. Jan Wijnholds
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
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Keywords
- hereditary retinal disease
- retinal inflammation
- retinal gene augmentation, editing, optogenetics and splice modulation therapy
- natural history studies of the retina
- human iPSC-derived retina and retinal pigment epithelium
- retinal iPSC-derived cell therapy
- retinal pathology
- pre- and clinical gene therapy
- animal models for retinal dystrophy
- retinal imaging
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