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Artificial Intelligence: Applications in the Field of Immune-Mediated Inflammatory Diseases and Onco-Hematology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 30 July 2025 | Viewed by 767

Special Issue Editors


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Guest Editor
Department of Internal Medicine, University of Genoa and San Bartolomeo Hospital, 19038 Sarzana, Italy
Interests: immunodeficiency; autoimmunity; neuro-endocrino-immunology; pharmacogenomics; soluble molecules; immune-mediated diseases; allergies; vaccines
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Guest Editor
Department of Clinical and Experimental Medicine, School and Operative Unit of Allergy and Clinical Immunology, University of Messina, 98125 Messina, Italy
Interests: mediators of inflammation; cytokines; biomarkers of oxidative stress; immunosenescence; immunogenetics; epigenetics; application of machine learning; deep learning in various fields of medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Artificial intelligence (AI) is becoming increasingly interesting and applied in various fields, including the biomedicine. Medicine is particularly involved because techniques based on machine learning (ML) allow us to improve the accuracy of medical diagnoses or to anticipate the outcome of possible therapeutic interventions.

Specifically, ML is utilized in the field of immune-mediated diseases, providing support for the diagnosis of systemic forms, such as systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, and Sjogren's syndrome. It also helps in the early prediction of their involvement within individual viscera (lungs, heart, kidneys, gastrointestinal tract, etc.). For example, the application of AI in patients with systemic sclerosis can lead to an early diagnosis of interstitial lung disease and ILD, anticipating functional signs shown by traditional techniques, such as spirometry and pH impedance analysis.

ML, deep learning (DL), and natural language processing (NLP) techniques hold promise to revolutionize diagnosis and therapy in the onco-hematological field. This is possible thanks to their ability to automatically analyze huge amounts of information in a digital format (clinical data, pathological anatomy, and so-called multiomics data, which concern the circulating immune profile, radiomics, genomics, and RNA sequencing) to characterize neoplasms.

This Special Issue is led by Prof. Dr. Giuseppe Murdaca and Prof. Dr. Sebastiano Gangemi, and assisted by Dr. Francesca Paladin from the Department of Internal Medicine and Medical Specialties (DIMI) at University of Genoa in Genoa, Italy. It aims to collect and analyze the most recent scientific evidence supporting the use of AI in immunology and onco-hematological fields. Both review and research articles are welcome. Please note that pure clinical studies or models are not suitable for this journal; however, clinical submissions with biomolecular studies are welcome.

Prof. Dr. Giuseppe Murdaca
Prof. Dr. Sebastiano Gangemi
Guest Editors

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Keywords

  • artificial intelligence
  • machine learning
  • immune-mediated diseases
  • cancers
  • hematological ma-lignancies

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Published Papers (1 paper)

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Review

19 pages, 760 KiB  
Review
Utilization of Machine Learning in the Prediction, Diagnosis, Prognosis, and Management of Chronic Myeloid Leukemia
by Fabio Stagno, Sabina Russo, Giuseppe Murdaca, Giuseppe Mirabile, Maria Eugenia Alvaro, Maria Elisa Nasso, Mohamed Zemzem, Sebastiano Gangemi and Alessandro Allegra
Int. J. Mol. Sci. 2025, 26(6), 2535; https://doi.org/10.3390/ijms26062535 - 12 Mar 2025
Viewed by 654
Abstract
Chronic myeloid leukemia is a clonal hematologic disease characterized by the presence of the Philadelphia chromosome and the BCR::ABL1 fusion protein. Integrating different molecular, genetic, clinical, and laboratory data would improve the diagnostic, prognostic, and predictive sensitivity of chronic myeloid leukemia. However, without [...] Read more.
Chronic myeloid leukemia is a clonal hematologic disease characterized by the presence of the Philadelphia chromosome and the BCR::ABL1 fusion protein. Integrating different molecular, genetic, clinical, and laboratory data would improve the diagnostic, prognostic, and predictive sensitivity of chronic myeloid leukemia. However, without artificial intelligence support, managing such a vast volume of data would be impossible. Considering the advancements and growth in machine learning throughout the years, several models and algorithms have been proposed for the management of chronic myeloid leukemia. Here, we provide an overview of recent research that used specific algorithms on patients with chronic myeloid leukemia, highlighting the potential benefits of adopting machine learning in therapeutic contexts as well as its drawbacks. Our analysis demonstrated the great potential for advancing precision treatment in CML through the combination of clinical and genetic data, laboratory testing, and machine learning. We can use these powerful research instruments to unravel the molecular and spatial puzzles of CML by overcoming the current obstacles. A new age of patient-centered hematology care will be ushered in by this, opening the door for improved diagnosis accuracy, sophisticated risk assessment, and customized treatment plans. Full article
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