Unraveling Immunometabolism in Sepsis: From Cellular Reprogramming to Therapeutic Targets
A Special Issue of International Journal of Molecular Sciences (ISSN 1422-0067) belonging to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 January 2027 | Viewed by 1391
Editor
Interests: sepsis; gastrointestinal bleeding; pancreatitis; infection; COVID-19; head trauma; helicobacter pylori infection; coeliac disease; breath tests for liver function; IBD; microbiota
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Sepsis continues to pose a major clinical and scientific challenge worldwide, driven by a complex interplay between dysregulated immune responses and profound metabolic disturbances. In recent years, immunometabolism has emerged as a crucial lens through which to reinterpret the pathophysiology of sepsis. Cellular metabolic reprogramming influences leukocyte activation, cytokine production, pathogen clearance, and ultimately the trajectory of organ dysfunction. Understanding these intricate bioenergetic shifts not only deepens our insight into disease mechanisms but also reveals a spectrum of novel biomarkers and actionable therapeutic targets.
This Special Issue, “Unraveling Immunometabolism in Sepsis: From Cellular Reprogramming to Therapeutic Targets”, aims to gather cutting-edge research and authoritative reviews that explore the metabolic underpinnings of immune dysregulation in sepsis. We encourage contributions investigating molecular pathways, translational approaches, diagnostic innovations, and experimental or clinical interventions that harness immunometabolic modulation. By bringing together expertise from immunology, metabolism, critical care, and systems biology, we hope to foster a multidisciplinary dialog that advances both scientific understanding and clinical impact. Researchers are warmly invited to submit their latest findings to help shape a more precise and therapeutically informed vision of sepsis care.
Dr. Marcello Candelli
Guest Editor
Manuscript Submission Information
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Keywords
- sepsis
- immunometabolism
- metabolic reprogramming
- cellular bioenergetics
- innate and adaptive immunity
- mitochondrial dysfunction
- inflammatory signaling
- metabolic biomarkers
- therapeutic modulation
- host–pathogen interactions
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