The Role of Glycans in Immune Regulation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 July 2025 | Viewed by 1810
Special Issue Editor
Interests: glycotherapy and medicine; chemical glycobiology; chemoproteomics; cancer biology; genoproteomics
Special Issue Information
Dear Colleagues,
Immune cells are covered by a heavy layer of glycans, serving as essential determinants of the fate of immune responses and potential targets for modulating immune tolerance and activation in various pathologic settings. This coregulatory network involves different glycan structures and their multivalent cis- or trans-interactions with binding receptors. Some glycan and binding receptor interactions (e.g., sialic acids and the Siglecs axis) have been newly recognized as immune checkpoints orthogonal to the well-established protein immune checkpoints (e.g., PD-1/PD-L1). However, deciphering these coregulatory networks is important and is largely complicated by the lack of tools.
This Special Issue aims to provide a platform for functional research on glycans in immune systems. We believe that this Special Issue will contribute to an in-depth understanding of glycoimmunology and the development of interventions to cure related diseases in the future, including cancers, autoimmune inflammation, and chronic infection. We welcome your submissions of original papers and reviews focusing on the immunomodulatory functions of glycans.
Dr. Senlian Hong
Guest Editor
Manuscript Submission Information
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Keywords
- glycoimmunology
- glycotherapy
- vaccines
- glycan synthesis
- immune tolerance
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