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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Editorial Board Members’ Collection Series: Cancer Metastasis

edited by

Carlos Cabañas

and

Sung-Hoon Kim

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7923 | Submission Open

Keywords: biomarkers; liquid biopsy; premetastatic niche; angiogenesis; immune evasion and suppression; genetic and epigenetic determinants; chemoresistance; extracellular vesicles

(This special issue belongs to the Section Molecular Oncology)

The Impact of Natural Bioactive Compounds on Human Health and Disease

edited by

Yeong-geun Lee

submission deadline 31 Dec 2025 | 4 articles | Viewed by 4531 | Submission Open

Keywords: natural product chemistry; nuclear magnetic resonance; structural elucidation; herbal drug

(This special issue belongs to the Section Molecular Pharmacology)

Research Progress of Metabolomics in Health and Disease

edited by

Maria Assunta Acquavia

submission deadline 31 Dec 2025 | 6 articles | Viewed by 4466 | Submission Open

Keywords: metabolomics; health; diseases; target metabolites; mass spectrometry; hyphenated techniques

(This special issue belongs to the Section Molecular Biology)

Targeted Delivery of Nucleic Acids

edited by Yong-Serk Park

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3596 | Submission Open

Keywords: nucleic acid delivery; gene delivery; pDNA delivery; siRNA delivery; miRNA delivery; mRNA delivery; CRISPR-Cas delivery; nanoparticle; lipid nanoparticle; targeted therapy

(This special issue belongs to the Section Molecular Biology)

Recent Progress in Metabolic Diseases

edited by

Dariusz Chlubek

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1873 | Submission Open

Keywords: metabolic diseases; enzymes related to metabolic disorders; inborn errors of metabolism; inherited single-gene anomalies; molecular diagnostics in metabolic disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancements in Diagnostic and Preventive Pharmacogenomics

edited by Alireza Tafazoli

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1563 | Submission Open

Keywords: genome profiling; pharmacogenetic analysis; diagnostic pharmacogenomics; pre-emptive pharmacogenomics; advanced genotyping technologies

(This special issue belongs to the Section Molecular Pharmacology)

Advances in the Relationship Between Diet and Insulin Resistance

edited by

Domenico Sergi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1536 | Submission Open

Keywords: insulin resistance; lipotoxicity; lipid metabolism; type 2 diabetes mellitus; dietary lipids; lipidomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Forensic Molecular Biology and Genetics

edited by

Anna Barbaro

submission deadline 31 Dec 2025 | Viewed by 923 | Submission Open

Keywords: nuclear and mt-DNA; rapid DNA analysis; next-generation sequencing; mRNA analysis; microbiome analysis; barcode DNA; time since deposition; fluid identification; DNA phenotyping; DNA ancestry

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into RNA Diseases

edited by

Naoyuki Kataoka

submission deadline 31 Dec 2025 | 1 articles | Viewed by 733 | Submission Open

Keywords: RNA splicing; RNA modification; RNA processing; translation; RNA transport

(This special issue belongs to the Section Molecular Genetics and Genomics)

Emerging Trends in Enzymology

edited by

Francesco Malatesta

submission deadline 31 Dec 2025 | Viewed by 565 | Submission Open

(This special issue belongs to the Section Biochemistry)

Molecular Entomology of Insects of Economic Importance: Advanced Molecular Approaches for Insect Pest Management

edited by

T. G. Emyr Davies

submission deadline 31 Dec 2025 | Viewed by 336 | Submission Open

Keywords: molecular entomology; insect pests; agricultural pests; disease vectors; beneficial insects; CRISPR; RNA interference; genome-wide approaches; computational biology; nanotechnology

(This special issue belongs to the Section Molecular Biology)

Chelating Ligands in Therapeutics: Recent Advances and Future Directions

edited by

Matteo Mori

and

Fiorella Meneghetti

submission deadline 31 Dec 2025 | Viewed by 314 | Submission Open

Keywords: metal complexes; chelation therapy; chelating agents; diagnostic imaging; metal detoxification; chelation pharmacokinetics

(This special issue belongs to the Section Biochemistry)

Selected Papers from the 5th International Symposium on Frontiers in Molecular Science (ISFMS)

edited by

Yoshinori Marunaka

and

Masayuki Takahashi

submission deadline 31 Dec 2025 | Viewed by 313 | Submission Open

Keywords: protein structure and function; multidomain proteins; drug design and drug resistance; enzymes; molecular biology of galectins; glycobiophysics; NMR spectroscopy; specific sensory systems; brain and systemic function

(This special issue belongs to the Section Biochemistry)

Functional Microbiomes and the Organization of Marine Communities: Molecular Biological Insights

edited by

Daniel Rittschof

submission deadline 31 Dec 2025 | Viewed by 210 | Submission Open

Keywords: marine communities; functional microbiomes; exoenzymes; chemical communication; organization of complex ecosystems

(This special issue belongs to the Section Molecular Microbiology)

Cutting-Edge Insights into Bacterial Infection and Host Immune Response

edited by Pablo C. Baldi

submission deadline 31 Dec 2025 | Viewed by 61 | Submission Open

Keywords: bacteria– host interaction; virulence factors; cellular and molecular immune response; immune evasion mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Highlights in Pathophysiology and Treatment of Osteoarthritis

edited by

Antonella Fioravanti

and

Serena Guiducci

submission deadline 31 Dec 2025 | Viewed by 33 | Submission Open

Keywords: osteoarthritis; pathophysiology (cytokines; adipokines; chemokines; epigenetics; microbiome); cartilage; synovial membrane; subchondral bone; treatment; disease-modifying osteoarthritis drugs; non-pharmacological treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Medicinal Plants in Drug Discovery: Unveiling Potential Applications and Molecular Mechanisms

edited by Abdelhakim Bouyahya

submission deadline 31 Dec 2025 | Viewed by 30 | Submission Open

Keywords: bioactive compounds; pharmacodynamic; clinical efficacy; chemotherapeutic drugs

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Iron in Human Physiology: Molecular Mechanisms and Therapeutic Applications

edited by

Alireza Morovat

submission deadline 31 Dec 2025 | Viewed by 24 | Submission Open

Keywords: iron; hepcidin; ferroportin; ferritin; transferrin; metabolic regulation; cell signaling; cellular processes; mitochondrial function; stress response; inflammation; ferroptosis; gene regulation; disorders

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Research on Adipose Tissue Development and Functions, 2nd Edition

edited by

Younghoon Jang

submission deadline 31 Dec 2025 | Viewed by 12 | Submission Open

Keywords: adipose tissue; development; expansion; white adipose tissue; brown adipose tissue; beige adipose tissue; adipocytes; adipogenesis; lipogenesis; peroxisome proliferator-activated receptor gamma (PPAR-γ ); CCAAT enhancer binding proteins (CEBP-α ; CEBP-β ; and CEBP-δ ); carbohydrate response element binding protein (ChREBP)

(This special issue belongs to the Section Molecular Biology)

Advances in Plant RNA Biology: Non Coding RNAs in Plant Development, Defense, and Adaptation

edited by

Andrew Eamens

submission deadline 31 Dec 2025 | Viewed by 11 | Submission Open

Keywords: plant RNA biology; regulatory RNA; non-coding RNA; small RNA (including miRNAs and siRNAs); RNA interacting proteins; plant development; plant pathogen defense; plant environmental stress adaptation

(This special issue belongs to the Section Molecular Plant Sciences)

Bacterial Infections: Unraveling Pathogenesis, Resistance, and Therapeutic Frontiers

edited by

Jagoda Jablonska

submission deadline 31 Dec 2025 | Viewed by 3 | Submission Open

Keywords: antimicrobial resistance; host– pathogen interactions; bacterial molecular pathogenesis; therapeutic target discovery

(This special issue belongs to the Section Molecular Microbiology)

Biomarkers Related to Molecular Targeted Radiotherapies

edited by Vija Lavinia

submission deadline 31 Dec 2025 | Submission Open

Keywords: biomarkers; molecular targeted radiotherapies; prognostic biomarkers; predictive biomarkers; single or composite biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Early Diagnosis and Advanced Therapies of Genetic Disorders

edited by

Milen Velinov

submission deadline 31 Dec 2025 | Submission Open

Keywords: genetic disorders; rare diseases; disease diagnostics; therapeutic targets; gene variants

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Atherosclerosis and Comorbidities: From Molecular Pathogenesis to Diagnosis and Therapeutic Targets

edited by

Alexandr Ceasovschih

Victoriţa Şorodoc

and Yusuf Ziya Şener

submission deadline 31 Dec 2025 | Submission Open

Keywords: atherosclerosis; comorbidities; lipidology; inflammation; obesity; arterial stiffness; vascular remodeling; cardiovascular risk; cardiovascular diseases; targeted therapies; lifestyle

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Molecular Research on Chronic Heart Failure

edited by

Marco Tana

submission deadline 1 Jan 2026 | 2 articles | Viewed by 3219 | Submission Open

Keywords: chronic heart failure (CHF); cardiovascular medicine; cardiac amyloidosis; biomarkers; translational ap-proaches; molecular approaches; pharmacological treatment; molecular mechanisms; molecular pathways; prognosis; clinical practice in CHF management

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Poly- and Oligo-Saccharides as Pharmaceutical Agents in Biology and Medicine

edited by

Kevin H. Mayo

submission deadline 1 Jan 2026 | Viewed by 80 | Submission Open

Keywords: polysaccharides; oligosaccharides; isolation and purification; structural and functional analyses; biological mechanisms of action; cellular & molecular targets and interactions; pharmaceutical drug development; cancer; cardiovascular disease; diabetes

(This special issue belongs to the Section Molecular Biology)

Molecular Signatures in Overt Neurodegenerative Disease: Toward Precision Diagnosis and Classification

edited by

Jose Miguel Laffita-Mesa

submission deadline 1 Jan 2026 | Submission Open

Keywords: neurodegenerative diseases; molecular biomarkers; disease stratification; Parkinson’ s disease; Alzheimer’ s disease; spinocerebellar ataxia; precision medicine; digital PCR; circRNA; prognostic biomarkers

(This special issue belongs to the Section Molecular Neurobiology)

From Microbes to Humans: Unveiling the Dynamic World of Carbonic Anhydrases (CAs)

edited by

Clemente Capasso

submission deadline 10 Jan 2026 | Viewed by 484 | Submission Open

Keywords: metalloenzymes; bacteria; pathogens; sulfonamides; inhibitors; activators; anti-infective agents; medicine; anticancer; neurodegenerative diseases; biomedical applications; biotechnology

(This special issue belongs to the Section Biochemistry)

Natural-Derived Bioactive Compounds in Disease Treatment

edited by

Adelina Vlad

and

Marilena Gilca

submission deadline 20 Jan 2026 | 4 articles | Viewed by 10795 | Submission Open

Keywords: medicinal plants; phytochemicals; vitamins; nutraceuticals; anti-oxidants; gene expression; protein expression; cellular signaling; nanoformulations

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanism Underlying Plant Drought and Salinity Stress Tolerance

edited by

Marzena Kurowska

and

Boris Lazarević

submission deadline 20 Jan 2026 | 4 articles | Viewed by 7177 | Submission Open

Keywords: drought; salinity; oxidative stress; antioxidant mechanism; photosynthesis; aquaporins; gene expression analysis

(This special issue belongs to the Section Molecular Plant Sciences)

Biochemical and Molecular Aspects of Bioremediation of Soils with Organic Pollutants by Microorganisms

edited by

Mariusz Cycoń

submission deadline 20 Jan 2026 | 4 articles | Viewed by 4208 | Submission Open

Keywords: bioremediation; soil pollution; organic pollutants; microorganisms; microbial communities; gene expression; enzyme degradation; molecular tools; indigenous soil microorganisms; contaminated soils

(This special issue belongs to the Section Molecular Microbiology)

Renin-Angiotensin System in Health and Diseases

edited by

Keiko Hosohata

submission deadline 20 Jan 2026 | 2 articles | Viewed by 3716 | Submission Open

Keywords: coronavirus disease 2019 (COVID-19); SARS-CoV-2; RAAS; spike protein; angiotensin; ACE2; clinical study; basic experiments

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Breeding and Genetic Regulation of Crops, 2nd Edition

edited by

Chiara Biselli

submission deadline 20 Jan 2026 | 1 articles | Viewed by 1041 | Submission Open

Keywords: molecular breeding; genetic regulation; genomics; genome-editing techniques; epigenetic modifications

(This special issue belongs to the Section Molecular Plant Sciences)

Virus Infection and Infectious Diseases: Unraveling Mechanisms, Innovations and Therapeutic Strategies—Second Edition

edited by Jung-Hyun Lee

submission deadline 20 Jan 2026 | 2 articles | Viewed by 1007 | Submission Open

Keywords: mechanism of virus infection; host immune responses; innovations in diagnostics and surveillance; therapeutic strategies; epidemiology and global health; data science for infectious disease; zoonotic transmission; virus evolution

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Therapies for Melanoma

edited by Anna Piotrowska

submission deadline 20 Jan 2026 | 1 articles | Viewed by 598 | Submission Open

Keywords: melanoma; targeted therapy; BRAF/MEK inhibitors; immunotherapy; anti-PD-1 and anti-CTLA-4 immunotherapy; melanoma microenvironment; cancer-associated fibroblasts (CAFs)/melanoma-associated fibroblasts (MAFs); MAPK (mitogen-activated protein kinase) signaling pathway

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research Progress on Oocyte Development

edited by

Ken-ichi Sato

submission deadline 20 Jan 2026 | 1 articles | Viewed by 400 | Submission Open

Keywords: oocyte maturation; germ cell development; folliculogenesis; oocyte quality; egg cell development; oocyte activation; meiotic progression; fertility

(This special issue belongs to the Section Molecular Biology)

Drug Discovery and Development for Renal Disease Treatment

edited by

Keiko Hosohata

submission deadline 20 Jan 2026 | Viewed by 277 | Submission Open

Keywords: kidney disease; medicinal chemistry; drug discovery; computer-assisted drug design; drug targets; in vitro assays; epigenetic targets; multi-targeting compounds; biophysical methods; target engagement studies

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Animal Reproduction and Development

edited by

Yu-Feng Wang

submission deadline 20 Jan 2026 | Viewed by 232 | Submission Open

Keywords: spermatogenesis; oogenesis; fertilization; embryogenesis; cell division; cell differentiation; stem cell; abnormal development; obesity; cancer

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Autophagy, 2nd Edition

edited by

Maria Ines Vaccaro

submission deadline 20 Jan 2026 | Viewed by 160 | Submission Open

Keywords: ATG molecules; transcriptional and post translational modification; selective pathways; secretory pathways; complexes diseases; degenerative processes; inflammatory diseases; tumorigenesis; metabolism; proteostasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cardiovascular Diseases: Molecular Mechanisms and Potential Therapy (2nd Edition)

edited by

Andrea Ghiroldi

submission deadline 25 Jan 2026 | Viewed by 207 | Submission Open

Keywords: cardiovascular diseases; pathogenic mechanisms; genetics; cardiomyopathy; myocardial infarction; cardiac fibrosis; pharmacogenomics; drug discovery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advance in Polymers: Structuralization to Functionalization

edited by Wei Wu

submission deadline 25 Jan 2026 | Viewed by 24 | Submission Open

Keywords: polymer material; molecular weight; chain configuration; polymer chains; chemical groups

(This special issue belongs to the Section Materials Science)

Antimicrobial Materials: Molecular Developments and Applications

edited by Florina Iliescu

submission deadline 27 Jan 2026 | Viewed by 34 | Submission Open

Keywords: antimicrobial; polymers; nanotechnology; nanocomposites; molecular; green systems; POC; prophylaxis

(This special issue belongs to the Section Materials Science)

Immunotherapy Versus Immune Modulation of Leukemia

edited by Helga Maria Schmetzer

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4606 | Submission Open

Keywords: leukemia; immunotherapy; immune modulation; antileukemic; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Drug-Induced Modulation and Immunotherapy of Leukemia

edited by Helga Maria Schmetzer

submission deadline 20 Feb 2026 | 2 articles | Viewed by 3576 | Submission Open

Keywords: leukemia; dendritic cells; immunotherapy; immune modulation

(This special issue belongs to the Section Molecular Immunology)

Sperm Oxidative Stress and Male Infertility

edited by

Kamil Gill

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1216 | Submission Open

Keywords: oxidative stress; antioxidant system; free radical scavengers; sperm DNA oxidation; sperm DNA fragmentatio; antioxidant therapy; male infertility; male oxidative stress infertility

(This special issue belongs to the Section Molecular Biology)

Osteoporosis: From Molecular Research to Novel Therapies

edited by

Agostino Gaudio

and Anastasia Xourafa

submission deadline 20 Feb 2026 | Viewed by 190 | Submission Open

Keywords: osteoporosis; bone metabolism; OPG/RANK/RANKL system; Wnt/beta catenin signalling; secondary osteoporosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drug Discovery Based on Natural Products

edited by Woo-kyung Kim

submission deadline 28 Feb 2026 | 4 articles | Viewed by 5116 | Submission Open

Keywords: drug discovery; bioactive compounds; pharmacological activities and mechanisms; omics technologies

(This special issue belongs to the Section Molecular Pharmacology)

Hormones: Evolutionary and Functional Role

edited by

Giulia Guerriero

submission deadline 20 Mar 2026 | 1 articles | Viewed by 892 | Submission Open

Keywords: hormone action; brain organization; sexual behavior; endocrine tissue; receptor neuroexpression; endocrine control; endocrine disruption; climate change and reproduction; hormones and evolution

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Therapies and Strategies in the Treatment of Neurodegenerative Diseases

edited by

Polina Petkova-Kirova

submission deadline 20 Mar 2026 | 1 articles | Viewed by 850 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; aging; memory; dementia; motor dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Enzyme Inhibitors: Mechanisms, Applications, and Future Perspectives

edited by

Clemente Capasso

and

Valeria Pittalà

submission deadline 30 Mar 2026 | 4 articles | Viewed by 3789 | Submission Open

Keywords: enzyme inhibitors; drug design; drug discovery; drug therapy; resistance mechanisms; cancer; drug delivery systems; biocatalysts; enzymes in industrial applications

(This special issue belongs to the Section Biochemistry)

Displaying special issue 3401-3450 on page 69 of 70.

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