RNA-Based Regulation in Human Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 30 August 2025 | Viewed by 52
Special Issue Editors
2. Department of Science and Technology, University of Naples “Parthenope", Centro Direzionale, Isola C4-800143, Naples, Italy
Interests: human genetic diseases; molecular mechanism pathogenesis; whole-transcriptome analysis; non-coding RNAs
Special Issues, Collections and Topics in MDPI journals
Interests: oxidative stress; DNA damage; aging; translational repression; apoptosis; SnoRNA regulation; antioxidants
Special Issue Information
Dear Colleagues,
RNA molecules are essential regulators of gene expression, playing key roles not only in protein synthesis but also in various cellular processes. Recent advancements in our understanding of non-coding RNAs (ncRNAs), including small nucleolar RNAs (snoRNAs), long non-coding RNAs (lncRNAs), microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), and circular RNAs (circRNAs), have revealed their significant roles in gene regulation, chromatin remodeling, RNA modification, and cellular signaling. These non-coding RNA species are now recognized for their involvement in critical biological processes, and their dysregulation has been implicated in numerous human diseases, including cancer, cardiovascular disorders, neurodegenerative diseases, and metabolic syndromes. With the growing impact of RNA-based therapies, such as RNA interference (RNAi), antisense oligonucleotides (ASOs), and mRNA vaccines, understanding the role of RNA in health and disease is crucial.
For this Special Issue, we invite original research articles and reviews that explore the following topics:
RNA modifications and their role in disease;
RNA-mediated gene regulation and cellular processes;
RNA-based therapeutic approaches to human diseases;
Non-coding RNAs in cancer, neurodegeneration, and cardiovascular diseases;
Technological advancements in RNA sequencing and bioinformatics.
Prof. Dr. Alfredo Ciccodicola
Dr. Sudharshan Setra Janardhana Shetty
Guest Editors
Manuscript Submission Information
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Keywords
- non-coding RNAs (ncRNAs)
- small nucleolar RNAs (snoRNAs)
- long non-coding RNAs (lncRNAs)
- microRNAs (miRNAs)
- piwi-interacting RNAs (piRNAs)
- circular RNAs (circRNAs)
- RNA modifications (m6A, pseudouridylation)
- RNA-protein interactions
- post-transcriptional gene regulation
- RNA interference (RNAi)
- antisense oligonucleotides (ASOs)
- RNA-binding proteins (RBPs)
- epitranscriptomics
- RNA-based therapeutics
- cancer-associated ncRNAs
- neurodegenerative diseases and RNA regulation
- cardiovascular RNA biology
- metabolic disorders and RNA
- ribosomal RNA modifications
- RNA-targeted drug discovery
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