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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bioinformatics and Machine Learning for Predicting Biological Processes

edited by Hao Lv

submission deadline 30 Nov 2025 | 1 articles | Viewed by 7114 | Submission Open

Keywords: bioinformatics; machine learning; multi-omics integration; gene regulation; biological processes; disease processes; data-driven discovery

(This special issue belongs to the Section Molecular Informatics)

Nuclear Receptors in Diseases

edited by Roberto Palacios-Ramirez

submission deadline 30 Nov 2025 | 3 articles | Viewed by 6056 | Submission Open

Keywords: nuclear receptors; hormone receptors; orphan receptors; retinoid receptors; metabolic diseases; cancers; drug metabolism

(This special issue belongs to the Section Molecular Biology)

Role of Calprotectin in Human Health and Disease

edited by

Mats B. Eriksson

and

Anders O. Larsson

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5654 | Submission Open

Keywords: acute phase reactants; analysis; bacterial infection; biomarker; calprotectin; critical care; inflammation; turbidimetric

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Renal Dysfunction, Uremic Compounds, and Other Factors (3rd Edition)

edited by

Giovana S. Di Marco

and

Marcus Brand

submission deadline 30 Nov 2025 | 3 articles | Viewed by 5605 | Submission Open

Keywords: renal dysfunction; acute kidney disease; chronic kidney disease; soluble mediators; uremic toxins; disease progression; organ cross-talk; therapy; new techniques

(This special issue belongs to the Section Molecular Toxicology)

Molecular and Clinical Aspects of Migraine and Its Comorbidities: Epilepsy, Stroke, and Restless Leg Syndrome

edited by

Janusz Blasiak

and Michał Fila

submission deadline 30 Nov 2025 | 2 articles | Viewed by 5476 | Submission Open

Keywords: migraine; genetics and epigenetics of migraine; migraine comorbidities; omics in migraine studies; stem cells in migraine studies; epilepsy; stroke; restless leg syndrome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Dynamics Simulations and Structural Analysis of Protein Domains (2nd Edition)

edited by

Alexandre G. De Brevern

submission deadline 30 Nov 2025 | 5 articles | Viewed by 5195 | Submission Open

Keywords: protein structures; molecular dynamics; advanced molecular dynamics; variants; pathologies; drug design; allostery; protein domains; secondary structures; methodological development; protein design; ligands; normal mode analysis; machine learning

(This special issue belongs to the Section Molecular Informatics)

Multiple Sclerosis: The Latest Developments in Immunology and Therapy

edited by

Borros Michael Arneth

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4854 | Submission Open

Keywords: multiple sclerosis; sensory disturbances; movement disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Cardiac Disease

edited by

Daniela Rossin

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4273 | Submission Open

Keywords: innovative cardiac research; multidisciplinary cardiovascular approaches; advances in cardio-vascular diagnosis; novel cardiac therapies; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbiome Modulation Through Probiotics: Molecular Insights and Therapeutic Applications

edited by

Satya Prakash

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4142 | Submission Open

Keywords: live bacterial cells; prebiotic agents; synbiotic formulations; probiotic formulations; microbial dysbiosis; inflammation; oxidative stress; host– microbe interactions

(This special issue belongs to the Section Molecular Microbiology)

Cardiovascular Diseases: Aging and Other Risk Factors

edited by

Silvia Liskova

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3451 | Submission Open

Keywords: aging; hypertension; endothelium; vascular smooth muscle cells; pulmonary hypertension; atherosclerosis; hyperlipidemia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immunophenotyping in Autoimmune Diseases and Cancer, 4th Edition

edited by

Gabor J. Szebeni

and

Attila Balog

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3331 | Submission Open

Keywords: immunophenotyping; immune regulation; multiparameter cytometry; immuno-oncology; anti-tumor immunity; autoimmunity; cancer immunology; protein– protein interactions; structure/function relationships; sulfur amino acids

(This special issue belongs to the Section Molecular Immunology)

Mitochondrial Biology and Reactive Oxygen Species

edited by

Wieslawa Jarmuszkiewicz

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3011 | Submission Open

Keywords: mitochondrial biology; mitochondrial dysfunction; mitochondrial coenzyme Q; metabolic homeostasis; oxidative stress; reactive oxygen species

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring the Cytoskeleton and Its Regulators: From Structure to Function

edited by

Wan Lee

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2935 | Submission Open

Keywords: cytoskeleton; cytoskeleton-binding protein; cytoskeletal protein; cell signaling; mechanotransduction; cell proliferation; cell migration; cellular motility; cell differentiation; structural biology

(This special issue belongs to the Section Molecular Biology)

Role of NRF2 Pathway in Chronic Diseases

edited by

Ángel Juan García-Yagüe

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2894 | Submission Open

Keywords: chronic diseases; NRF2; oxidative stress; inflammation; neurodegenerative diseases; cardiovascular disease; autoimmune diseases; chronic kidney diseases; liver disease

(This special issue belongs to the Section Biochemistry)

Latest Advances in Plant Abiotic Stress

edited by

Kincső Decsi

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2835 | Submission Open

Keywords: abiotic stress factors; priming effects; defense responses; biochemical pathway analyses; transcriptomics; plant conditioners; next-generation sequencing; genome-wide analyses

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Advances in Iron Metabolism, Ferritin and Hepcidin Research: 3rd Edition

edited by

Edina Pandur

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2603 | Submission Open

Keywords: iron; hepcidin; ferroportin; ferritin; regulation; anemia; therapies; cell signaling; inflammation; disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Roles of Phytochemicals and Antioxidants in Colon Cancers

edited by

Nunzio Antonio Cacciola

, Francesca Borrelli and

Paola De Cicco

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2297 | Submission Open

Keywords: colon cancer; colorectal cancer; natural products; drug-resistant; phytochemicals; antioxidants; cellular and molecular mechanisms; anti-cancer activity; prevention; treatments

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Cages: Design, Synthesis, and Applications

edited by

Vicente Martí-Centelles

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2294 | Submission Open

Keywords: molecular cages; supramolecular chemistry; synthetic chemistry; self-assembly; molecular design; host– guest chemistry; biological applications

(This special issue belongs to the Section Macromolecules)

Translational Oncology: From Molecular Basis to Therapy

edited by

Mario Cioce

and Gatti Veronica

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2058 | Submission Open

Keywords: cancer; therapy resistance; translational oncology; cancer stem cells; immunotherapy; cancer metabolism; OMICS; patient-derived-organoids; drug repositioning; TKI

(This special issue belongs to the Section Molecular Oncology)

Melatonin: Physiological Effects on Health and Diseases

edited by

Jana Tchekalarova

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1875 | Submission Open

Keywords: hormone melatonin; oxidative stress; sleep; metabolism; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Mast Cells in Human Health and Diseases—3rd Edition

edited by

Giovanna Traina

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1829 | Submission Open

Keywords: mast cells; human diseases; pain; cardiovascular diseases; microbiome; food allergy; stress; cancer

(This special issue belongs to the Section Molecular Biology)

Impact of Circulatory and Blood Clotting Dysfunctions in Infectious Diseases

edited by

Hsin-Hou Chang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1654 | Submission Open

Keywords: infectious diseases; circulatory dysfunction; coagulation disorders; endothelial activation; platelet aggregation; anticoagulant therapy; diagnostic biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Soybean Molecular Breeding

edited by Dong Cao

submission deadline 30 Nov 2025 | 3 articles | Viewed by 1291 | Submission Open

Keywords: soybean; plant architecture; adaptation; yield improvement; molecular breeding; nutritional quality traits; stress tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research in Hematologic Malignancies

edited by

Rachid Lahlil

and

Anne Aries

submission deadline 30 Nov 2025 | 2 articles | Viewed by 1242 | Submission Open

Keywords: therapeutic targets; leukemogenesis; molecular regulation; cancer stem cells; epigenetics; novel biomarkers; non-coding RNA; DNA methylation; chemotherapy and genetic changes; cancer; hematologic malignancies

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into the Developmental Origins of Health and Disease, 2nd Edition

edited by

Paramjit S. Tappia

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1224 | Submission Open

Keywords: Developmental Origins of Health and Disease (DOHaD); fetal development; maternal nutrition; molecular programming; epigenetic modifications; environmental exposures; genetic factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Multifunctional Magnetic Nanoparticles: Synthesis, Properties, and Biomedical Applications

edited by

Krishtappa Manjunatha

submission deadline 30 Nov 2025 | Viewed by 1104 | Submission Open

Keywords: magnetic nanoparticles; molecular functionalization; magnetocaloric materials; drug delivery systems; molecular imaging; magnetic memory; nanocomposites; nanophosphors; environmental remediation; energy storage materials; magnetic biosensing; biofunctional interfaces

(This special issue belongs to the Section Molecular Nanoscience)

Latest Insights into Glycobiology

edited by

Csaba Váradi

and

Cheorl-Ho Kim

submission deadline 30 Nov 2025 | 1 articles | Viewed by 991 | Submission Open

Keywords: glycosylation; biomarkers; separation techniques; mass spectrometry; multivariate data analysis

(This special issue belongs to the Section Molecular Biology)

Cellular and Molecular Mechanisms of Blood–Brain Barrier (BBB) Dysfunction and Dementia

edited by Mark Slevin

submission deadline 30 Nov 2025 | 1 articles | Viewed by 920 | Submission Open

Keywords: blood– brain barrier; Alzheimer’ s disease; endothelial dysfunction; amyloid beta; tau; neuroinflammation; oxidative stress; aging; gut– brain axis; therapeutic strategies

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Therapeutic Targeting of Inflammatory Complications

edited by

Kota V. Ramana

submission deadline 30 Nov 2025 | 1 articles | Viewed by 884 | Submission Open

Keywords: inflammation; oxidative stress; cytokines; autoimmune diseases; infectious diseases; cancer; targeted therapies; molecular pathways; asthma; sepsis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Innate Immune System in Renal Diseases

edited by

Takashi Oda

submission deadline 30 Nov 2025 | 1 articles | Viewed by 838 | Submission Open

Keywords: innate immune system; acquired immunity; complement system; dendritic cells; monocyte/macrophages (Mϕ); polymorphonuclear leukocytes; NK/NKT cells; innate lymphoid cells (ILCs); AKI; CKD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Study on Organellar Genomes of Vascular Plants

edited by

Monika Szczecińska

submission deadline 30 Nov 2025 | 1 articles | Viewed by 696 | Submission Open

Keywords: mitochondrial DNA (mtDNA); chloroplast DNA (cpDNA); plant evolution; plant organellar genome; genomics

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms in Mitochondria-Targeted Drug Delivery System

edited by

Maria Manuel Oliveira

and

Francisco Peixoto

submission deadline 30 Nov 2025 | Viewed by 646 | Submission Open

Keywords: mitochondria; mitochondrial diseases; nanoformulations; therapeutic agents; drug release; precision medicine

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms Governing Lipid Metabolism in Health and Disease

edited by

Christina E. Kostara

submission deadline 30 Nov 2025 | 1 articles | Viewed by 621 | Submission Open

Keywords: lipidomics; lipid biomarkers; lipid metabolism; cardiovascular disease; cardiometabolic diseases; non-alcoholic fatty liver disease; diabetes; lipoproteins; NMR spectroscopy; mass spectrometry

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nutrition, Inflammation, and Chronic Kidney Disease

edited by

Denise Mafra

submission deadline 30 Nov 2025 | 1 articles | Viewed by 590 | Submission Open

Keywords: chronic kidney disease; inflammation; nutrients; bioactive compounds

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Dermatology: Advances in Pathophysiology and Therapies (3rd Edition)

edited by

Montserrat Fernández-Guarino

submission deadline 30 Nov 2025 | 2 articles | Viewed by 581 | Submission Open

Keywords: immunodermatology; cutaneous lymphoma; cutaneous drug reaction; erythroderma; psoriasis; atopic dermatitis; eczematous reactions; cutaneous manifestation of systemic diseases; cutaneous vasculitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Zebrafish Model for Neurological Research

edited by

Mattia Toni

submission deadline 30 Nov 2025 | 1 articles | Viewed by 566 | Submission Open

Keywords: zebrafish ; Danio rerio ; brain ; nervous system

(This special issue belongs to the Section Molecular Neurobiology)

Intrinsically Disordered Proteins (IDPs): From Structure to Mechanism and Function

edited by

Kyouhoon Han

submission deadline 30 Nov 2025 | Viewed by 546 | Submission Open

Keywords: IDP; NMR; completely unstructured; pre-structured; PreSMo; target binding

(This special issue belongs to the Section Biochemistry)

Plant Biology and Biotechnology: Focus on Genomics, Bioinformatics and AI

edited by

Yuriy L. Orlov

and

Ming Chen

submission deadline 30 Nov 2025 | 1 articles | Viewed by 544 | Submission Open

Keywords: gene expression regulation in plants; ncRNA and gene editing in plants; AI applications in plant bioinformatics; molecular mechanisms of stress resistance in plants; ncRNA and gene editing in plants; plant– pathogen interactions; systems biology and ecological networks for agrobiology; next-generation sequencing in plants; modeling of plant cell growth; gene networks and pathway modeling in plants; computer phenotyping of plants

(This special issue belongs to the Section Molecular Informatics)

Cutting-Edge Advances in Natural Bioactive Compounds

edited by

Joachim Storsberg

submission deadline 30 Nov 2025 | Viewed by 537 | Submission Open

Keywords: natural bioactive compounds; phytochemicals; fungal metabolites; antioxidant activity; anti-inflammatory agents; antimicrobial compounds; anti-cancer compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Macrophage Polarization and Human Inflammatory Diseases

edited by

Mary Cloud B. Ammons

submission deadline 30 Nov 2025 | Viewed by 530 | Submission Open

Keywords: macrophage polarization; inflammation; metabolic immunomodulation; epigenetics; in vitro models; in vivo models; diagnostics; therapeutics; infectious disease; metabolic disease

(This special issue belongs to the Section Molecular Pharmacology)

Cyclic Nucleotide-Signaling in Cells and Tissues: Molecular, Functional, and Pharmacological Aspects

edited by

Jens Schlossmann

submission deadline 30 Nov 2025 | 1 articles | Viewed by 514 | Submission Open

Keywords: cyclic nucleotide; cNMP; cAMP; cGMP; cCMP; cUMP; cGAMP; signaling proteins; signal transduction pathways; scaffolds; nitric oxide; natriuretic peptides; adenylyl cyclases; guanylyl cyclases; kinases; phosphodiesterases; channels; (patho)physiology; pharmacology

(This special issue belongs to the Section Biochemistry)

Enhancing Stem Cell Grafting in Tissue Regeneration and Repair

edited by

Yuanyuan Zhang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 503 | Submission Open

Keywords: stem cell therapy; tissue regeneration; graft enhancement; molecular mechanisms; engraftment; biomaterials; immunomodulation

(This special issue belongs to the Section Molecular Biology)

Research in Genetic Causes of Adult-Onset Disorders

edited by

Claudio Graziano

submission deadline 30 Nov 2025 | Viewed by 496 | Submission Open

Keywords: ADPKD; cardiomyopathy; CADASIL; amyloidosis; MODY; late-onset hearing impairment; penetrance; adult onset

(This special issue belongs to the Section Molecular Genetics and Genomics)

Pancreatic Disease: From Molecular Basis to Novel Therapies—2nd Edition

edited by

Agnieszka B. Bialkowska

submission deadline 30 Nov 2025 | Viewed by 489 | Submission Open

Keywords: pancreatitis; acinar-to-ductal neoplasia; early pancreatic neoplasia; fibroinflammatory disease; pancreatic cancer; diabetes Mellitus

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Traits in Animals and Aquatic Species, and Their Improvement Technologies

edited by

Lishi Yang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 464 | Submission Open

Keywords: biotechnology; genetic breeding; stress responses; epigenetics; non-coding RNAs; gene regulation; molecular ecology; animals; aquaculture; development

(This special issue belongs to the Section Molecular Biology)

Mechanisms of Resistance to Melanoma Immunotherapy

edited by Marko B. Lens

submission deadline 30 Nov 2025 | 1 articles | Viewed by 453 | Submission Open

Keywords: melanoma; immune checkpoint inhibitors; PD-1

(This special issue belongs to the Section Molecular Oncology)

State-of-the-Art Molecular Genetics and Genomics in Poland: 3rd Edition

edited by

Ewa Fiedorowicz

and

Anna Cieslinska

submission deadline 30 Nov 2025 | Viewed by 453 | Submission Open

Keywords: RNA; DNA; DNA structure; damage; and repair; post-translational modifications; autophagy; cell cycle; gene expression; functions and therapy; mutation; nuclear organization; polymerase; nucleic acid– protein interactions; molecular clone; sequencing analysis; epigenetics; transcriptomics; genetics of aging; genetic disorders; SNP; etc

(This special issue belongs to the Section Molecular Genetics and Genomics)

Structural Codes of Sphingolipids and Their Involvement in Diseases

edited by

Sandro Sonnino

and

Elena Chiricozzi

submission deadline 30 Nov 2025 | 1 articles | Viewed by 453 | Submission Open

Keywords: sphingolipids; sphingolipid hydrophilic head; sphingolipid hydrophobic tail; sphingolipid signalling; sphingolipid diseases

(This special issue belongs to the Section Biochemistry)

Molecular and Cellular Therapeutics for Respiratory Diseases

edited by

Roberto Plebani

submission deadline 30 Nov 2025 | 1 articles | Viewed by 432 | Submission Open

Keywords: lung diseases; cystic fibrosis; chronic obstructive pulmonary disease; asthma; drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Gastrointestinal Inflammation: From Pathogenesis to Molecular Diagnosis and Treatment

edited by

Nikolett Bódi

submission deadline 30 Nov 2025 | Viewed by 420 | Submission Open

Keywords: gastrointestinal tract; inflammation; gastroenteritis; infection; microbiome; mucosal epithelium; immune cells; enteric nervous system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 1851-1900 on page 38 of 70.

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