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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Chitosan Biomaterials: Advances and Challenges—2nd Edition
edited by , and Cristina Elena Dinu-Pirvu
submission deadline 31 Jul 2024 | 2 articles | Viewed by 2229 | Submission Open
Keywords: chitosan; chitosan biomaterials; chitosan derivatives; drug delivery; wound healing; tissue regeneration; dentistry; smart biomaterials
(This special issue belongs to the Section Materials Science)
Demyelinating Diseases: From Molecular Mechanisms to, Therapeutic Strategies 3.0 submission deadline 31 Jul 2024 | 2 articles | Viewed by 2192 | Submission Open
Keywords: biomarkers; cellular and molecular biology; cell differentiation; cellular metabolism; demyelinating diseases; drug developing strategies and drug repositioning; glia cell (oligodendrocytes; astrocytes and microglia); inflammation; lipid metabolism; mitochondria; myelination and remyelination nuclear receptors; nutraceuticals; signal transduction mechanisms; target identification
(This special issue belongs to the Section Molecular Neurobiology)
Integrative Oncology: From the Lab to New Therapeutic Possibilities—2nd Edition submission deadline 31 Jul 2024 | 1 articles | Viewed by 2173 | Submission Open
Keywords: integrative oncology; cancer therapy; cancer prevention; natural products; microbiota; epigenetics on cancer
(This special issue belongs to the Section Molecular Oncology)
Neuroinflammation Toxicity and Neuroprotection 2.0
edited by
submission deadline 31 Jul 2024 | 2 articles | Viewed by 2131 | Submission Open
Keywords: neuroinflammation neurotoxicity; neurotoxicity; neuroprotection; neurodegenerative diseases; stroke; brain tumors; anti-inflammatory agents
(This special issue belongs to the Section Molecular Toxicology)
Molecular Mechanism of Gastric Cancer
edited by Jiping Zeng
submission deadline 31 Jul 2024 | 2 articles | Viewed by 2129 | Submission Open
Keywords: gastric cancer; Helicobacter pylori; cell death; cancer metabolism; tumor microenvironment; immunity and inflammation; epigenetics; non-coding RNAs; protein modification; bioinformatics
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanism Discovery of the Bioactive Phytochemicals against Different Diseases Based on Network Pharmacology and Molecular Docking
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1986 | Submission Open
Keywords: molecular mechanism; phytochemicals; network pharmacology; molecular docking; diseases; curing targets; signaling pathway; biological processes
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Insights in Steroid Biosynthesis and Metabolism
edited by Amanda C. Swart
submission deadline 31 Jul 2024 | 2 articles | Viewed by 1980 | Submission Open
Keywords: steroid biosynthesis; steroid metabolism; aldo-keto reductase (AKR); cytochrome P450; steroid reductase (SRD5A); 17β -hydroxysteroid dehydrogenases (17β HSD); 11β -hydroxysteroid dehydrogenase (11β HSD); reproduction and sexual differentiation; endogenous cardiac steroids; anabolic steroids; prostate cancer; gut microbiome; immune system; inflammation; cardiovascular disease (CVD); kidney function; hormone replacement therapy (HRT)
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Cystic Fibrosis: Molecular Pathogenesis, Diagnosis, and Treatment
edited by Valeria Rachela Villella
submission deadline 31 Jul 2024 | 2 articles | Viewed by 1908 | Submission Open
Keywords: CFTR protein interactions; molecular mechanism and processing; modulators; new drugs; pathogenesis and theratyping
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Trends in Stereoselective Synthesis and Chiral Catalysis
edited by
submission deadline 31 Jul 2024 | 3 articles | Viewed by 1898 | Submission Open
Keywords: chiral synthesis; natural source; stereoselective; bioactive compounds; organocatalysis; chiral pools; biomolecules; pharmacological activity; chiral building blocks
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Cell Metabolism and Small Natural Compounds 2.0 submission deadline 31 Jul 2024 | 1 articles | Viewed by 1838 | Submission Open
Keywords: cell metabolism; mitochondria; ROS; RNS; proliferation and cell death; metabolic pathways; natural compounds; bioactive molecules; human pathology
(This special issue belongs to the Section Biochemistry)
Recent Advances in Biomolecule and Bioprocess Engineering for Sustainable Environment
edited by , and Chulhwan Park
submission deadline 31 Jul 2024 | 2 articles | Viewed by 1836 | Submission Open
Keywords: bioactive molecule; biocatalyst; biochar; bioconversion; biomass; biorefinery; biopolymer; bioprocess; biotechnology
(This special issue belongs to the Section Biochemistry)
New Insights into Photosystem I submission deadline 31 Jul 2024 | 4 articles | Viewed by 1776 | Submission Open
Keywords: photosystem I; photochemisty; electron transfer; protein– cofactor interaction; reaction kinetics; reaction mechanism; redox tuning; light harvesting; low-energy (red) forms; bioenergetics; cyclic electron transfer
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Characterization of Plant-Virus Interactions
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1684 | Submission Open
Keywords: plant virus; host cell; molecular mechanism; replication; translation; defence; infection
(This special issue belongs to the Section Molecular Plant Sciences)
Gynecologic Cancer: From Molecular, Cellular Mechanisms to Novel Therapies
edited by Sun-Young Lee
submission deadline 31 Jul 2024 | 2 articles | Viewed by 1664 | Submission Open
Keywords: cervical cancer; endometriosis; uterine fibroids; ovarian cancer; pelvic mass; uterine cancer; vaginal cancer; vulvar cancer; molecular-targeted therapy; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Pulmonary Fibrosis: Molecular Pathology, Diagnosis, and Therapeutic Strategies submission deadline 31 Jul 2024 | 2 articles | Viewed by 1637 | Submission Open
Keywords: pulmonary fibrosis; biomarker; molecular pathways; omics sciences; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Ribbon Synapses: Molecular Mechanisms of Synaptic Signaling and Involvement in Diseases 2.0 submission deadline 31 Jul 2024 | 2 articles | Viewed by 1580 | Submission Open
Keywords: ribbon synapses; molecular anatomy and physiology of ribbon synapses; retina; inner ear ribbon synapses; pineal gland; synaptic ribbon; exocytosis; endocytosis; neuronal networks; circadian rhythms and circadian signaling
(This special issue belongs to the Section Molecular Neurobiology)
Multidrug Resistance in Cancer: Molecular Mechanisms and Therapeutic Implications
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1547 | Submission Open
Keywords: cancer drug resistance; cancer stem cells; tumor microenvironment; gut microbiome; cancer secretome; extracellular vesicles; -omics; biomarkers; combination therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research of Multi-omics in Cancer
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1523 | Submission Open
Keywords: bioinformatics; biomedical informatics; high-throughput sequencing (HTS)/next-generation sequencing (NGS); DNA-Seq/genomics; RNA-Req/transcriptomics; mass spectrometry/proteomics  
(This special issue belongs to the Section Molecular Oncology)
Molecular Landscape of Cutaneous Wound Healing in Health and Disease
edited by , and Annalucia Carbone
submission deadline 31 Jul 2024 | 2 articles | Viewed by 1469 | Submission Open
Keywords: chronic non-healing wounds; epidermal stem cells; Wnt; hydrogels; dermal regeneration templates; induced pluripotent stem cells; mesenchymal stem cells; exosomes; miRNA
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pathophysiological and Molecular Insights into Heart Failure: From Diagnosis to Therapy
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1409 | Submission Open
Keywords: heart failure; pathophysiology; diagnosis; pharmacological therapy; device therapy; microRNAs; myocardial biomarkers; molecular pathways
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug Treatment for Bacterial Infections
edited by Janusz Madaj
submission deadline 31 Jul 2024 | 2 articles | Viewed by 1389 | Submission Open
Keywords: bacterial infection; antibiotic-resistant bacteria; new agents in the treatment of bacterial infections; optimization of the use of already registered drugs; single antibacterial agents; combined antibacterial agents; new drug forms
(This special issue belongs to the Section Molecular Pharmacology)
The Role of Inflammatory Cytokines (Interleukins Family) in Human Disease
edited by Diego Fresegna
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1378 | Submission Open
Keywords: cytokine signaling; immunotherapy; immune modulation; precision medicine; disease pathogenesis; immunological disorders; therapeutic targets; inflammation biomarkers; immunomodulatory drugs; cellular immune response
(This special issue belongs to the Section Molecular Immunology)
Molecular Genetics and Plant Breeding 4.0
edited by
submission deadline 31 Jul 2024 | 2 articles | Viewed by 1306 | Submission Open
Keywords: crop biodiversity; wild accessions; molecular breeding; QTL and gene mapping; comparative genomics; drought stress adaptation; disease resistance; yield and sustainability; GWAS mapping; predictive breeding; genomic prediction
(This special issue belongs to the Section Molecular Genetics and Genomics)
Cardiomyopathy: From Pathologies to Therapy
edited by Zuzana Nichtová
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1302 | Submission Open
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Head and Neck and Skin Cancer
edited by Nerina Denaro, and Iorio Giuseppe Carlo
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1290 | Submission Open
Keywords: head and neck cancer; melanoma; nonmelanoma skin cancer; immunotherapy; tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
Molecular Insight into Zoonotic Infections
edited by Marine Combe
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1271 | Submission Open
Keywords: zoonoses; zoonotic pathogens; neglected zoonotic diseases; molecular assays; genetic diversity; PCR; qPCR; ddPCR; sequencing; NGS
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Cancer Biomarkers, Artificial Intelligence and Emerging Technologies
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1264 | Submission Open
Keywords: cancer; biomarker; pathology; risk factors; artificial intelligence; advanced technologies; personalized medicine; targeted therapy
(This special issue belongs to the Section Molecular Oncology)
New Insights into Neurotoxicity
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1221 | Submission Open
Keywords: neurotoxicity; neurotoxicants; nervous system; heavy metal
(This special issue belongs to the Section Molecular Neurobiology)
Hormone Signaling in Human Health and Diseases 2.0
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1185 | Submission Open
Keywords: hormone; cell receptor; endocrine signaling; cancer; insulin; oestrogen; testosterone; angiotensin; gonadotropin; thyroid hormone
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular and Cellular Mechanisms of Apoptosis and Senescence
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1157 | Submission Open
Keywords: apoptosis; cellular senescence; cancer; neurodegenerative diseases
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Bioelectrochemistry submission deadline 31 Jul 2024 | 1 articles | Viewed by 1143 | Submission Open
Keywords: bioelectrochemical devices; molecular bioelectrochemistry; bioelectrochemical sensors; DNA sensors; protein sensors; detection of proteins and DNA; cancer; human disease; electrode surface; electrochemical biointerfaces
(This special issue belongs to the Section Biochemistry)
Mitochondrial Dysfunction and Oxidative Stress in Parkinson’s Disease
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1141 | Submission Open
Keywords: Parkinson’ s disease (PD); reactive oxygen species (ROS); oxidative stress (OS); mitochondrial respiratory chain (MRC); mitochondrial dysfunction; glutathione; pentose phosphate pathway
(This special issue belongs to the Section Molecular Neurobiology)
Advances and Perspectives in Limbal Epithelial Stem Cells and Their Niche
edited by and Ursula Schlötzer-Schrehardt
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1114 | Submission Open
Keywords: limbal epithelial stem cells; ocular surface; limbal stem cell niche; homeostasis; limbal mesenchymal stromal cells; regeneration; limbal melanocytes; extracellular matrix components
(This special issue belongs to the Section Biochemistry)
Bone Biomaterials Research and 3D Spheroid Culture Systems in Osteogenesis
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1079 | Submission Open
Keywords: osteogenic differentiation; 3D culture; bone regeneration; toxicological and pharmacological assessment; bone homeostasis; bone materials
(This special issue belongs to the Section Materials Science)
Mycotoxins, Immunity, and Inflammation 2024
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 1026 | Submission Open
Keywords: mycotoxin; immunity; inflammation; immunotoxicity; immunology
(This special issue belongs to the Section Molecular Toxicology)
Noncovalent Interactions Involving Transition Metal Atoms submission deadline 31 Jul 2024 | 1 articles | Viewed by 979 | Submission Open
Keywords: noncovalent interactions; transition metal elements; supramolecular assemblies; σ - and π -hole interactions; theoretical chemistry; synthesis and structural characterization of noncovalent complexes
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Biomarkers in Neoplastic and Degenerative CNS Diseases: Defining New Advances in Clinical Usefulness and Therapeutic Molecular Target
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 951 | Submission Open
Keywords: Alzheimer’ s disease; brain cancer; clinical usefulness; therapeutic target
(This special issue belongs to the Section Molecular Neurobiology)
Computational Studies in Drug Design and Discovery
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 921 | Submission Open
Keywords: molecular docking; homology modeling; repositioning; virtual screening; QSAR; molecular dynamics; ADME prediction  
(This special issue belongs to the Section Molecular Informatics)
Molecular Advances in Biotechnological Approaches to Developing Effective Antimicrobial Agents
edited by José M. Pérez De la Lastra
submission deadline 31 Jul 2024 | 1 articles | Viewed by 890 | Submission Open
Keywords: biotechnological; antimicrobial agents; IgY antibodies; peptides; drug resistance; antimicrobial resistance (AMR); drug-resistant fungi; drug-resistant viruses
(This special issue belongs to the Section Molecular Immunology)
The Role of CAR T Cells in Human Health and Disease
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 873 | Submission Open
Keywords: CAR T cells; vector design; combined vaccination and CAR T cell therapy; non-viral transductioin; genetic engineering
(This special issue belongs to the Section Molecular Biology)
Molecular Research in Three-Dimensional Model Systems for Pharmacological Approaches submission deadline 31 Jul 2024 | 1 articles | Viewed by 832 | Submission Open
Keywords: regenerative medicine; stem cells; microfluidics; oral stem cells; osteoregeneration; biomaterials; epithelial– mesenchymal transition; extracellular vesicles
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biosynthesis and Regulatory Mechanism of Secondary Metabolites in Medicinal Plants 2.0
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 810 | Submission Open
Keywords: biosynthetic pathway; epigenetic regulation; high-throughput sequencing; medicinal plant; metabolic engineering; omics; regulatory mechanism; secondary metabolite; synthetic biology; transcription factor
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Scale Design, Synthesis, and Application of Macroporous, Mesoporous, and Microporous Materials submission deadline 31 Jul 2024 | 1 articles | Viewed by 783 | Submission Open
Keywords: macro-; meso- and microporous; porous materials; molecular design; adsorption; porous organic frameworks
(This special issue belongs to the Section Materials Science)
Editorial Board Members’ Collection Series: Genome Stability submission deadline 31 Jul 2024 | 1 articles | Viewed by 779 | Submission Open
Keywords: genome stability; DNA damage response; DNA repair; DNA replication; DNA recombination; ATR/ATM pathway; GENOTOXINS
(This special issue belongs to the Section Molecular Genetics and Genomics)
Neuropathological Features of Aging and Neurodegenerative Diseases
edited by Renpei Sengoku
submission deadline 31 Jul 2024 | 1 articles | Viewed by 733 | Submission Open
Keywords: neuropathology; aging; Alzheimer’ s disease; Parkinson’ s disease; Parkinsonism; progressive supranuclear palsy; cortcobasal degeneration
(This special issue belongs to the Section Molecular Neurobiology)
Advanced Research on Biomarkers in Gastrointestinal Cancer 2.0
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 677 | Submission Open
Keywords: serum biomarkers; circulating DNA; microRNAs; tumor tissue; individualized therapy; gene profile; oncology; pathology; gastric cancer; colorectal cancer; esophageal cancer; carcinogenesis in oral mucosa; hepatocellular carcinoma; cholangiocarcinoma; pancreatic cancer; familial cancer
(This special issue belongs to the Section Molecular Oncology)
Genetic Research in Cardiac Diseases
edited by Maria Teresa De Angelis
submission deadline 31 Jul 2024 | 1 articles | Viewed by 663 | Submission Open
Keywords: heart development; heart diseases; animal models; patient-derived pluripotent stem cell-cardiomyocytes (PSC-CMs); genome editing; genetically induced diseased PSC-CMs; 3D cardiac disease models
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Analysis and Applications of Mass Spectrum in Biochemistry 2.0
edited by
submission deadline 31 Jul 2024 | 1 articles | Viewed by 651 | Submission Open
Keywords: soft-ionization mass spectrometry; hard-ionization mass spectrometry; environmental metabolomics; food-omics; biological tissue analysis and clinical diagnostics; quantitative analysis; structural analysis; imaging mass spectrometry
(This special issue belongs to the Section Biochemistry)
Molecular Pathways in Myocardial Dysfunction and Cardioprotection submission deadline 31 Jul 2024 | Viewed by 554 | Submission Open
Keywords: myocardial dysfunction; cardiomyopathy; myocardial infarction; diabetes mellitus; hypertension; hyperglycemia; circulating fatty acids; reactive oxygen species; metabolic syndrome; ageing; sepsis; cardiac myocytes; cardiac remodeling; cardioprotection; coronary arteries; preconditioning; mitochondria; endoplasmic reticulum; autophagy; renin– angiotensin system; lipotoxicity; inflammation; fibrosis; heart failure
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Therapies for Acute Myeloid Leukemia
edited by
submission deadline 31 Jul 2024 | Viewed by 501 | Submission Open
Keywords: acute myeloid leukemia; BCL2 inhibitors; leukemic cells; new therapies for AML; prognostic implications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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