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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Lung Cancer: From Genetic Landscape to Treatment

edited by Rossella Bruno

submission deadline 26 Aug 2025 | 1 articles | Viewed by 1567 | Submission Open

Keywords: lung cancer; precision medicine; predictive biomarkers; resistance mechanisms; targeted therapy; immunotherapy; molecular tests; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Recent Research on Optoelectronic Materials

edited by

Meysam Tayebi

submission deadline 28 Aug 2025 | Viewed by 177 | Submission Open

Keywords: photoelectrochemistry; optoelectronic materials; perovskite materials; semiconductor interfaces; molecular-level catalysis; solar fuel conversion; nanostructured materials; light-harvesting systems

(This special issue belongs to the Section Materials Science)

Mechanistic Insights into Pharmacological and Non-Pharmacological Pain Therapies: From Cellular Responses to Therapy Outcomes

edited by

Sungtae Koo

submission deadline 28 Aug 2025 | Viewed by 147 | Submission Open

Keywords: neuromodulation; neural plasticity; glial activation; endogenous pain modulation; neuroinflammation; therapeutic mechanisms

(This special issue belongs to the Section Molecular Pharmacology)

Recent Advances in Molecular Pharmacology of Neurological Diseases

edited by

Chian Ju Jong

submission deadline 28 Aug 2025 | Viewed by 99 | Submission Open

Keywords: neurological diseases; neurodevelopmental disorders; neurodegenerative diseases; therapeutic agents; drug discovery; molecular pharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Biology of Plant Disease Resistance

edited by Heewan Kang

submission deadline 28 Aug 2025 | Viewed by 74 | Submission Open

Keywords: Bacillus subtilis; antifungal activity; amino acids; defense genes; molecular mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

The Neuro and Immune Mechanisms Behind Cannabinoids Effects

edited by

Babak Baban

submission deadline 28 Aug 2025 | Viewed by 61 | Submission Open

Keywords: cannabinoids; neuroinflammation; endocannabinoid system (ECS); non-cannabinoid receptors; immune modulation; synaptic plasticity

(This special issue belongs to the Section Biochemistry)

Molecular Biomarkers for Assessing Marine Ecosystem Health

edited by

Maria Costantini

Valerio Zupo

and

Roberta Esposito

submission deadline 28 Aug 2025 | Viewed by 36 | Submission Open

Keywords: biodiversity; biomarkers; biomonitoring; marine organisms; pollution; metals; microplastics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immune Regulation During Pregnancy

edited by Sabrina Marie Scroggins

submission deadline 28 Aug 2025 | Viewed by 34 | Submission Open

Keywords: maternal– fetal immunology; multiomics in pregnancy; in utero inflammation; therapeutics; placental biology; neurodevelopment; gestational disorders; epigenetics; microbiome

(This special issue belongs to the Section Molecular Immunology)

Anti-Inflammatory and Anti-Oxidant Effects of Extracts from Plants

edited by

Sheila Leone

and

Lucia Recinella

submission deadline 29 Aug 2025 | 1 articles | Viewed by 388 | Submission Open

Keywords: oxidative stress; inflammation; herbal extracts

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Application and Formulation of Therapeutic Natural Deep Eutectic Solvents

edited by

Kunn Hadinoto Ong

submission deadline 29 Aug 2025 | Viewed by 76 | Submission Open

Keywords: deep eutectic solvent; ionic liquid drug; eutectic mixture; green solvent; pharmaceutical salts

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights into Thrombosis

edited by

J. Kh. Khizroeva

submission deadline 30 Aug 2025 | 6 articles | Viewed by 14573 | Submission Open

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Research on the Role of the Gut Microbiota in Human Diseases and Health

edited by

Sanda Cretoiu

submission deadline 30 Aug 2025 | 5 articles | Viewed by 10846 | Submission Open

Keywords: microbiota; microbiome; gut microbiome metabolites; dysbiosis; gut– organ axis; gut microbiota pathogens; diet

(This special issue belongs to the Section Molecular Microbiology)

The Role of Extracellular Vesicles in Cancer Diagnosis and Therapy, 2nd Edition

edited by

Nils Ludwig

submission deadline 30 Aug 2025 | 3 articles | Viewed by 6718 | Submission Open

Keywords: extracellular vesicles; exosomes; intercellular communication; liquid biopsy; cancer therapeutics; nanotherapeutics

(This special issue belongs to the Section Molecular Oncology)

From Bench to Bedside: Well-Established and Emerging Preclinical Models in Cardiovascular Research

edited by

Laura Calvillo

and Veronica Dusi

submission deadline 30 Aug 2025 | 1 articles | Viewed by 4117 | Submission Open

Keywords: myocardial infarction; organ ischemia and reperfusion injury; hypertension; cardiovascular dysfunction; cardio-renal syndrome; stroke; arrhythmias; heart disease; heart failure; genetic disorders; translational medicine; organoids; bioreactors; organs on a chip; omics sciences; pharmacology; molecular biology; gene therapy; quantum biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Germline Stem Cells: New Insights

edited by

Thomas Skutella

submission deadline 30 Aug 2025 | 1 articles | Viewed by 3976 | Submission Open

Keywords: signaling pathway; spermatogonia development; oocyte development; microarray analysis; single-cell sequencing; epigenetic mechanisms; germline stem cell

(This special issue belongs to the Section Molecular Biology)

Unraveling the Molecular Mechanisms of Neurodegeneration

edited by

Michela Ferrucci

submission deadline 30 Aug 2025 | 4 articles | Viewed by 3837 | Submission Open

Keywords: protein accumulation; mitochondria; genetic and epigenetic alterations; oxidative stress; apoptosis; autophagy

(This special issue belongs to the Section Molecular Neurobiology)

Immunology of Infectious Disease and Transplantation: A Symbiotic Dance

edited by

Alessandro Perrella

submission deadline 30 Aug 2025 | 2 articles | Viewed by 3672 | Submission Open

Keywords: organ transplantation; infectious disease; immune responses; immunology; personalized medicine; transplantation medicine

(This special issue belongs to the Section Molecular Immunology)

Genetic Analysis Based on CRISPR/Cas9 Technology: 2nd Edition

edited by

Yong-Gu Cho

and

Kwon-Kyoo Kang

submission deadline 30 Aug 2025 | 2 articles | Viewed by 2989 | Submission Open

Keywords: gene targeting (GT); homology-directed repair (HDR); homology-directed gene targeting (HGT); CRISPR/Cas; targeted mutagenesis; precision breeding; genetic analysis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Transition Metal Catalysis: From Synthesis to Late-Stage Functionalization of Aromatics and Heterocycles

edited by

Antonio Del Vecchio

and

Fabio Bellina

submission deadline 30 Aug 2025 | 2 articles | Viewed by 2790 | Submission Open

Keywords: transition metal catalysis; homogeneous catalysis; heterogeneous catalysis; cross-couplings; synthesis of aromatics and heteroaromatics; late-stage functionalization; photo-; electro-; flow; mechanochemistry; medicinal chemistry; material sciences; bioinorganic chemistry; industrial processes

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

The Transcendental World of Plant Toxic Compounds

edited by

Helena Fernández

submission deadline 30 Aug 2025 | 1 articles | Viewed by 2105 | Submission Open

Keywords: alcaloids; biotic stress; defence; phenols; phytotoxins; secondary metabolism; terpenes

(This special issue belongs to the Section Molecular Plant Sciences)

The Extracellular Matrix in Physiopathology

edited by

Eric Huet

submission deadline 30 Aug 2025 | 1 articles | Viewed by 1744 | Submission Open

Keywords: extracellular matrix; glycosaminoglycans; matrix metalloproteinases; tissue remodeling; cell interactions; physiopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oral Soft Tissue Repair and Oral Diseases: 2nd Edition

edited by

Jacek Matys

submission deadline 30 Aug 2025 | 1 articles | Viewed by 1194 | Submission Open

Keywords: oral medicine; tissue regeneration; lasers; photobiomodulation; periodontology; implant dentistry

(This special issue belongs to the Section Molecular Biology)

Intracellular Trafficking and Catabolism of Free Heme: Physiological Roles and Relevance to Pathological Mechanisms

edited by Junichi Taira

submission deadline 30 Aug 2025 | 1 articles | Viewed by 1016 | Submission Open

Keywords: heme oxygenase; heme metabolism; heme chaperon; free heme (labile heme); cytochrome P450 reductase; reactive oxygen species; carbon monoxide

(This special issue belongs to the Section Biochemistry)

Plants Redox Biology

edited by

Xin Li

submission deadline 30 Aug 2025 | 1 articles | Viewed by 791 | Submission Open

Keywords: plant– environment interaction; stress physiology; plant redox signaling; plant hormones; plant– pathogen interaction; reactive oxygen species (ROS); reactive nitrogen species (RNS); ascorbate; flavonoid; glutathione

(This special issue belongs to the Section Molecular Plant Sciences)

Beyond the Known: Molecular Insights into the World of New Psychoactive Compounds

edited by

Helena Gaspar

and

Rita Pacheco

submission deadline 30 Aug 2025 | 1 articles | Viewed by 772 | Submission Open

Keywords: new psychoactive substances; synthetic drugs; metabolism; toxicology; drug checking; designer drugs

(This special issue belongs to the Section Macromolecules)

Plant-Microbe Interaction: Current Status and Future Directions

edited by

Juan Manuel Ruiz Lozano

submission deadline 30 Aug 2025 | Viewed by 758 | Submission Open

Keywords: beneficial micro-organism; climate change; crop productivity; environmental stress; food production; plant growth; stress mitigation; yield

(This special issue belongs to the Section Molecular Plant Sciences)

Biodegradable Polymers: From Chemical Synthesis to Biodegradable Mechanism

edited by

Ling-Ping Xiao

Oana Lelia Pop

and

Gabrijel Ondrasek

submission deadline 30 Aug 2025 | Viewed by 687 | Submission Open

Keywords: biodegradable polymers; polyolefins; molecular structures; synthesis; chemical modification; hydrolysis kinetics

(This special issue belongs to the Section Macromolecules)

Innovative Technologies in the Study and Understanding of Colorectal Tumorigenesis: Challenges and Opportunities

edited by

Paola Sena

submission deadline 30 Aug 2025 | 1 articles | Viewed by 623 | Submission Open

Keywords: colorectal cancer; genetic analysis; gut microbiome; tumor; circulating components; medicine; immunotherapy; proteomics

(This special issue belongs to the Section Molecular Oncology)

Cellular Plasticity and EMT in Cancer and Fibrotic Diseases

edited by

Sabrina Lisi

and

Margherita Sisto

submission deadline 30 Aug 2025 | 1 articles | Viewed by 509 | Submission Open

Keywords: fibrosis; epithelial– mesenchymal transition; epithelial– mesenchymal plasticity; cancer; fibrotic diseases; inflammation; metastases

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanism of Sympathetic Nerves in Cardiovascular Diseases and Cancer

edited by

Yutang Wang

submission deadline 30 Aug 2025 | Viewed by 489 | Submission Open

Keywords: sympathetic nerve activity; adrenergic receptors; renal denervation; heart disease; stroke; atherosclerosis; hypertension; diabetes; metabolic syndrome; cancer

(This special issue belongs to the Section Molecular Neurobiology)

Gastrointestinal Microbes: Implications for Health and Disease

edited by Suqin Hang

submission deadline 30 Aug 2025 | 1 articles | Viewed by 405 | Submission Open

Keywords: animal; gut; microbiota; gut hormone; nutrients

(This special issue belongs to the Section Molecular Microbiology)

Physics and Chemistry of Molecular Materials for Optoelectronic Applications

edited by

Aggelos Avramopoulos

submission deadline 30 Aug 2025 | Viewed by 376 | Submission Open

Keywords: polarization of matter; non-linear optics and non-linear optical phenomena; optical phenomena; quantum chemistry; density functional theory; physics and chemistry of molecular materials; molecular-based optoelectronics

(This special issue belongs to the Section Materials Science)

Role of Quorum Sensing in Plant Microbiome: Advances and Prospects

edited by

Clarisse Brígido

submission deadline 30 Aug 2025 | Viewed by 334 | Submission Open

Keywords: quorum sensing; quorum quenching; rhizosphere signaling; signaling molecules; N-Acyl-L-homoserine lactones; AHLs; microbiome; chemical molecules; sustainable agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Cytokines and Autoantibodies Against Cytokines in Health and Disease

edited by

Juan Bautista De Sanctis

submission deadline 30 Aug 2025 | Viewed by 308 | Submission Open

Keywords: cytokine; autoantibodies; cytokine therapy; cytokine inhibition

(This special issue belongs to the Section Molecular Immunology)

Latest Advances in Computational Drug Discovery

edited by

Sunil Gaikwad

submission deadline 30 Aug 2025 | Viewed by 250 | Submission Open

Keywords: design; synthesis; molecular docking; methodological reviews; novel docking approaches; ADME; toxicity; AI-driven molecular docking; molecular dynamics; bioisosteric replacement in drug design; rational drug design and synthesis; computational tools and algorithms; lead optimization and structure-based drug design; virtual screening of drug candidates; QSAR modelling; DFT

(This special issue belongs to the Section Molecular Pharmacology)

Recent Advances in Molecular Mechanisms and Targeted Therapies for Leukemia

edited by

Moo Kon Song

submission deadline 30 Aug 2025 | Viewed by 145 | Submission Open

Keywords: targeted therapy; acute myeloid leukemia; genetic mutations

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Nanosensors for Molecular Sensing Applications

edited by

Giorgio Rispoli

submission deadline 30 Aug 2025 | Viewed by 145 | Submission Open

Keywords: nanostructure; microfabrication; nanoparticles; nanotechnology; nanomaterials; sensor response; sensitivity; miniaturization; analyte selectivity; molecular recognition; biosensor; sensing mechanism; nanowires; affinity sensor

(This special issue belongs to the Section Molecular Nanoscience)

Environmental Sensitivity Illnesses: Advances in Mechanisms and Molecular Signatures

edited by

Daniela Caccamo

submission deadline 30 Aug 2025 | Viewed by 141 | Submission Open

Keywords: electromagnetic hypersensitivity; multiple chemical sensitivity; fibromyalgia; chronic fatigue syndrome; chronic pain disorder; toxicant-induced loss of tolerance; total allergy syndrome; circulating biomarkers; genetic susceptibility factors; immune system alterations

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research in Antioxidant Activity

edited by Demetrios Kouretas and

Fotios Tekos

submission deadline 30 Aug 2025 | Viewed by 137 | Submission Open

Keywords: xenobiotics; oxidative stress; free radicals; reactive oxygen species; reactive nitrogen species; antioxidants; glutathione; toxicology; redox metabolism; redox imbalance

(This special issue belongs to the Section Biochemistry)

Inflammation in Pregnancy and Childbirth

edited by

Małgorzata Szczuko

and Maciej Ziętek

submission deadline 30 Aug 2025 | Viewed by 136 | Submission Open

Keywords: pregnancy; labor; eicosanoid; chronic inflammation; cytokines; intestinal dysbiosis; mitogen-activated protein kinase; nuclear factor kappa-light-enhancer-activated B cell; maresins; resolvins and protectins

(This special issue belongs to the Section Molecular Immunology)

Application and Molecular Mechanisms of Microwaves for Materials Processing

edited by

Valentin Craciun

submission deadline 30 Aug 2025 | Viewed by 130 | Submission Open

Keywords: microwaves; non-ionizing radiation; molecular materials characterizations; molecular materials synthesis; microwave processing and engineering

(This special issue belongs to the Section Materials Science)

Molecular Insights into the Role of Exercise in Disease and Health, 2nd Edition

edited by

Brisamar Estébanez

, María José Cuevas-González and Chun-Jung Huang

submission deadline 30 Aug 2025 | Viewed by 127 | Submission Open

Keywords: physical activity; molecular mechanisms; disease prevention; metabolic health; cardiovascular diseases; neurodegenerative diseases; sarcopenia; immune function; healthy aging; epigenetics

(This special issue belongs to the Section Molecular Biology)

Artificial Intelligence and Computer-Aided Design: Molecular Simulation Technology in Exploring Bioactive Compounds for Health Promotion

edited by

Baojun Xu

submission deadline 30 Aug 2025 | Viewed by 126 | Submission Open

Keywords: molecular simulation; bioactive compounds; molecular docking; molecular dynamics; quantum mechanics; functional mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advancements in Novel Drug Delivery Systems for Gene and Drug Delivery

edited by

Rosamaria Pennisi

submission deadline 30 Aug 2025 | Viewed by 109 | Submission Open

Keywords: drug and gene delivery; novel drug delivery systems; nanoparticle-based delivery systems

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Endothelial Cell Injury and Repair

edited by

Eleni Gavriilaki

and

Panagiota Anyfanti

submission deadline 30 Aug 2025 | Viewed by 106 | Submission Open

Keywords: endothelial injury; endothelial repair; endotheliopathies; endothelial dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Plant–Microbe Interaction

edited by

Raja Ben-Laouane

and

Mohamed Ait-El-Mokhtar

submission deadline 30 Aug 2025 | Viewed by 106 | Submission Open

Keywords: biomarkers; molecular biotechnology; cell signalling; microbiota signaling; genetic editing of microbes; plant-microbe stress response; plant-microbe stress mitigation; plant-microbe underlying mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Lipoprotein in Cardiovascular Disease

edited by

Joan Carles Vallvé

submission deadline 30 Aug 2025 | Viewed by 97 | Submission Open

Keywords: lipoprotein; cardiovascular disease; atherosclerosis; lipid metabolism; HDL; LDL; VLDL; Lp(a); TRLs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Approaches for Tissue Repair and Tissue Regeneration

edited by Srinivas Madduri

submission deadline 30 Aug 2025 | Viewed by 89 | Submission Open

Keywords: injuries; tissue repair; tissue regeneration; tissue engineering; tissue bioengineering; bioactive biomaterial; cell and gene therapeutics; hydrogel; immune modulation

(This special issue belongs to the Section Molecular Biology)

Molecular Applications of Antioxidants and Anti-Inflammatory Activities of Natural Products

edited by

Vassilis Athanasiadis

submission deadline 30 Aug 2025 | Viewed by 87 | Submission Open

Keywords: antioxidants; anti-inflammatory agents; natural products; molecular mechanisms; oxidative stress; signaling pathways; inflammation; bioactive compounds; proteomics; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research on Plant Breeding

edited by