Liquid Biopsies in Oncology—3rd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 6226
Editors
Interests: breast cancer; circulating tumor cells (CTCs); cell-free DNA (cfDNA); cell-tumor DNA (ctDNA); liquid biopsies; genetic variants
Special Issues, Collections and Topics in MDPI journals
Interests: precision medicine; personalized medicine; cancer genomics; genomics; liquid biopsy; molecular diagnostic; laboratory medicine; clinical molecular biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the era of precision oncology, tumor molecular characterization plays a key role in selecting the right treatment for each patient at the right time. Technological advances, particularly next-generation sequencing (NGS), have paved the way to personalized medicine, reducing the time and costs required to assess the tumor’s genetic profile. Unfortunately, in some cases, tumor biopsies are not feasible, due to insufficient or inaccessible material. The use of liquid biopsies has revolutionized the standard clinical approach by allowing the detection of different circulating molecules in the bloodstream and other body fluids, which may have a key role in diagnosing and monitoring the evolution of the tumor, and evaluating the response or resistance to the treatment. Since their FDA approval in 2016, for a therapy-guiding blood-based test to detect EGFR mutations in lung cancer patients, liquid biopsies are emerging as the standard of care. Liquid biopsies have several advantages, including minimal invasiveness and repeatability, which could guarantee a dynamic picture of the tumor and the chance to monitor pharmacological responses to the biopsy.
We invite scientists to submit original research focused on the application of liquid biopsies as an innovative tool in cancer diagnosis and monitoring, as well as its possible application in clinical practice. Articles may also be focused on understanding how circulating molecules offer new therapeutic strategies in cancer treatment. Review articles that describe the state of the art on this topic are also encouraged. This Special Issue, focusing on liquid biopsies in oncology, includes the use of circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), circulating tumor RNAs (ctRNAs) as well as miRNAs, and extracellular vesicles (EVs). The topics of interest for this Special Issue include, but are not limited to, the following:
- Liquid biopsy for cancer screening, diagnosis, prognosis, follow-up and therapeutic management of tumors;
- Liquid biopsy for stratification and monitoring of cancer patients;
- Liquid biopsy for the detection of actionable oncogenic mutations in cancers;
- Liquid biopsy targeting ctDNA for molecular diagnosis of cancer;
- Clinical validity and utility of ctDNA and ctRNA for tumor analysis;
- Extracellular vesicle biomarkers;
- New techniques to evaluate cell-free molecules;
- Liquid biopsy on exosome for cancer diagnosis;
- Liquid biopsies and epigenetics.
Dr. Sandra V. Fernandez
Dr. Carmela Paolillo
Guest Editors
Manuscript Submission Information
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Keywords
- precision oncology
- personalized therapy
- cancer biomarkers
- liquid biopsy
- biological fluids
- circulating molecules
- circulating tumor cells
- CTCs
- ctDNA
- ctRNA
- cell-free DNA
- cfDNA
- NGS
- circulating miRNAs
- exosomes
- extracellular vesicles
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Related Special Issues
- Liquid Biopsies in Oncology in International Journal of Molecular Sciences (18 articles)
- Liquid Biopsies in Oncology II in International Journal of Molecular Sciences (8 articles)
