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Molecular Advances in Regenerative Medicine and Therapeutics

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 August 2025 | Viewed by 360

Special Issue Editor


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Guest Editor
Department of Life Science, Health and Health Professions, Link Campus University, 00165 Rome, Italy
Interests: anatomy; morphology; transmission electron microscopy; periodontal disease; biomaterials; regenerative medicine

Special Issue Information

Dear Colleagues,

Regenerative procedures in medicine and dentistry are still a challenge for researchers and clinicians. Understanding the biological and morphological reaction of human cells toward regenerative biomaterials is essential to choose the best-performing biomaterials for specific clinical situations. This Special Issue will provide a morpho-functional overview of the advances and different applications of regenerative procedures, focusing on the development of regenerative biomaterials, applied in different clinical contexts, both in the medical and in dental fields. In this Special Issue, original research articles and reviews are welcome, with the aim to highlight new, integrated, and multidisciplinary approaches of treatment in different clinical contexts. Research areas may include (but are not limited to) the following topics: advancements in regenerative biomaterials and their role in promoting tissue regeneration and repair—in the medical and dental fields; tissue engineering and scaffolds—for regenerative purposes; organoids; and cutting-edge technologies influencing the future of regenerative medicine.

Dr. Diana Torge
Guest Editor

Manuscript Submission Information

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Keywords

  • regenerative medicine
  • morphology
  • regenerative dentistry
  • biomaterials
  • scaffolds
  • organoids
  • tissue regeneration

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Published Papers (1 paper)

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Review

20 pages, 886 KiB  
Review
Platelet-Rich Plasma and Platelet-Rich Fibrin in Endodontics: A Scoping Review
by Simão Rebimbas Guerreiro, Carlos Miguel Marto, Anabela Paula, Joana Rita de Azevedo Pereira, Eunice Carrilho, Manuel Marques-Ferreira and Siri Vicente Paulo
Int. J. Mol. Sci. 2025, 26(12), 5479; https://doi.org/10.3390/ijms26125479 - 7 Jun 2025
Viewed by 244
Abstract
Conventional endodontic treatment has several disadvantages, which lead to the introduction of regenerative endodontic procedures aiming to maintain tooth vitality. Platelet concentrates possess relevant biological properties, and their application has been explored in various endodontic procedures. The aim of this scoping review is [...] Read more.
Conventional endodontic treatment has several disadvantages, which lead to the introduction of regenerative endodontic procedures aiming to maintain tooth vitality. Platelet concentrates possess relevant biological properties, and their application has been explored in various endodontic procedures. The aim of this scoping review is to identify the applications of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in endodontics. To identify and map the types of studies, the protocols for obtaining PRF/PRP, the most productive authors, and the journals where most articles were published on this topic until 2023. A literature search was performed in four databases (Medline, Embase, Cochrane Library, and Web of Science) until 20 December 2023. From the included articles, the following information was extracted: first author and publication year, endodontic procedure, platelet concentrate used, type of study, and journal of publication. A sampling methodology was adopted, and the five most recent articles for each procedure were used for additional information extraction: sample size and characteristics, pulp and periapical diagnosis, study protocol, platelet substrate and protocol for its obtention, treatment outcome, and follow-up. After selection, 412 articles were included. As for the type of endodontic procedure, regeneration procedures of immature teeth were the most reported, followed by apical surgery and pulpotomy and pulp protection. It was concluded that PRF is the most reported platelet concentrate. Regenerative procedures in immature teeth are the most described endodontic procedure. The success rate of PRF and PRP use is comparable to or even higher than that of conventional procedures and materials. However, there is significant heterogeneity in the protocols used for obtaining PRF and PRP and their clinical application. Full article
(This article belongs to the Special Issue Molecular Advances in Regenerative Medicine and Therapeutics)
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