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Targeting Oxidative Stress for Disease: 2nd Edition
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Targeting Oxidative Stress for Disease: 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 2362

Special Issue Editors

Prof. Dr. Nada Orsolic

E-Mail Website
Guest Editor
Department of Animal Physiology, Faculty of Science, University of Zagreb, 10000 Zagreb, Croatia
Interests: oxidative stress-induced diseases; natural products; chemoprevention and tumor therapy; bee products and health; radioprotection
Special Issues, Collections and Topics in MDPI journals
Dr. Maja Jazvinšćak Jembrek

E-Mail Website
Guest Editor
1. Division of Molecular Medicine, Rudjer Boskovic Institute, 10000 Zagreb, Croatia
2. School of Medicine, Catholic University of Croatia, 10000 Zagreb, Croatia
Interests: neuroprotection; neurotoxicity; neurodegenerative diseases; oxidative stress; polyphenols; neuropharmacology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidative stress (OS) represents the metabolic state of the organism induced by an increase in the amount of reactive oxygen species (ROS). It is most often associated with neurological diseases but also contributes to the pathogenesis of a number of seemingly unrelated disorders, including type 2 diabetes, cancer, aging, heart and acute renal failure, hypertension, preeclampsia, atherosclerosis and coronary disease, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, glaucoma, osteoporosis, and sexual dysfunction, among others.

This Special Issue aims to provide a comprehensive insight into the understanding of the role of ROS-mediated effects in the physiological, and especially in the pathological processes of diseases’ development. We would like to highlight the possibilities of exploiting OS as a therapeutic approach in the treatment of cancer.

We cordially invite authors to contribute original articles as well as review papers that present advances on the potential of the most relevant dietary antioxidants on redox biology. These include their antioxidant capacity that may affect biomarkers of oxidative stress and inflammation, as well as their role in the regulation of mitochondrial function, cell signaling proteins, ion channels and transporters, and the ubiquitination/proteasome system, preventing the occurrence of numerous pathological processes.

This Special Issue is supervised by Prof. Dr. Nada Orsolic and Dr. Maja Jazvinšćak Jembrek, assisted by our Topical Advisory Panel Member, Dr. Malamati Kourti (Department of Life Sciences, School of Sciences, European University Cyprus, Cyprus).

Prof. Dr. Nada Orsolic
Dr. Maja Jazvinšćak Jembrek
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidants and free radical production
  • physiological activities of free radicals
  • detrimental effects of free radicals on human health
  • ROS and ROS-mediated cellular signaling
  • pathophysiology of oxidative stress
  • biomarkers of oxidative stress
  • chronic degenerative diseases
  • therapeutic approaches targeting oxidative stress
  • biochemical/molecular targets of chronic diseases
  • exogenous antioxidants and human health
  • flavonoids and redox biology in the pathophysiology of diseases
  • pro-oxidative role of antioxidants: double-sided sword
  • prooxidant agents in therapy

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Related Special Issue

Published Papers (3 papers)

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Research

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17 pages, 5356 KiB  
Article
Cranberry Oil: A Potent Natural Intimate Care Ingredient Displaying Antioxidant and Anti-Inflammatory Effects and Promoting Beneficial Vaginal Lactobacillus
by Cloé Boira, Julia Jolibois, Anaïs Durduret, Jean Tiguemounine, Caroline Szewezyk, Morgane De Tollenaere, Amandine Scandolera and Romain Reynaud
Int. J. Mol. Sci. 2025, 26(5), 2176; https://doi.org/10.3390/ijms26052176 - 28 Feb 2025
Viewed by 556
Abstract
Cranberry oil is known for nutritional benefits, and this work is aimed at studying its soothing properties and potential as an intimate care ingredient. The antioxidant, anti-inflammatory, and anti-irritation properties of cranberry oil were evaluated on epithelial cells and tissues, including the vaginal [...] Read more.
Cranberry oil is known for nutritional benefits, and this work is aimed at studying its soothing properties and potential as an intimate care ingredient. The antioxidant, anti-inflammatory, and anti-irritation properties of cranberry oil were evaluated on epithelial cells and tissues, including the vaginal epithelium. The impact of the oil on vaginal microbiota was assessed in vitro. Cranberry oil reduced oxidative stress in keratinocytes (ROS −43%) and lowered inflammation by lessening the release of cytokines IL-8 (−33%) and TNF-α (−32%). Irritation induced by sodium dodecyl sulfate (SDS) in skin explants was lowered by 24%. Cranberry oil and fruit extract acted synergistically on inflammation, decreasing TNF-α release by 75% (vs. −34% and −16%, respectively). Cranberry oil reduced inflammation on EpiVaginal™ tissue, decreasing IL-6 by 36%. The minimum inhibitory concentration (MIC) of cranberry oil on the pathogenic vaginal microorganisms C. albicans and G. vaginalis was 0.5% and 0.1%, respectively. The oil promoted the growth of commensal L. jensenii (×79 at 0.1%) and favored a high proportion of lactic acid bacteria when co-cultured with C. albicans. Cranberry oil has antioxidant, anti-inflammatory, and soothing properties on skin. Anti-inflammatory activity was confirmed on vaginal epithelium, and initial in vitro evidence indicates that the oil can balance vaginal flora to prevent dysbiosis. Full article
(This article belongs to the Special Issue Targeting Oxidative Stress for Disease: 2nd Edition)
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14 pages, 4015 KiB  
Article
The Effect of a Secondary Stressor on the Morphology and Membrane Structure of an Already Challenged Maternal and Foetal Red Blood Cell Population
by Ágnes Ferencz, Payal Chakraborty, Csaba Papp, András Teleki, Krisztina Dugmonits, Hajnalka Orvos, Attila Gácser and Edit Hermesz
Int. J. Mol. Sci. 2025, 26(1), 333; https://doi.org/10.3390/ijms26010333 - 2 Jan 2025
Viewed by 848
Abstract
The red blood cell (RBC) membrane is unique and crucial for maintaining structural–functional relationships. Maternal smoking induces significant changes in the morphological, rheological, and functional parameters of both maternal and foetal RBCs, mainly due to the continuous generation of the free radicals. The [...] Read more.
The red blood cell (RBC) membrane is unique and crucial for maintaining structural–functional relationships. Maternal smoking induces significant changes in the morphological, rheological, and functional parameters of both maternal and foetal RBCs, mainly due to the continuous generation of the free radicals. The major aim of this study was to follow the consequences of a secondary stressor, like fungal infection, on the already compromised RBC populations. The impact of Candida infection, a growing health concern, was investigated on four blood sample groups: mothers and their neonates originating from non-smoking versus smoking populations. Here, we searched for phenotypical and molecular markers that precisely reflected the effect of Candida infection on the RBC membrane; this included the level of hemolysis, appearance of morphological variants, formation of the lipid peroxidation marker 4-hydroxyl-nonenal, arrangement of the Band 3 molecules and activation of the Caspase 3. In most of the examined cases, the fungal infection increased the adverse symptoms induced by smoking, indicating a general stress response, likely due to an altered redox state of the cells. However, we were able to identify an atypical phenotype (clustered populations with shrinkage and membrane blebbing) in both the non-smoking and smoking populations, which might be a unique marker for Candida spp. infection. Full article
(This article belongs to the Special Issue Targeting Oxidative Stress for Disease: 2nd Edition)
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Review

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34 pages, 1936 KiB  
Review
Nanozymes: Innovative Therapeutics in the Battle Against Neurodegenerative Diseases
by Carmen Duță, Carmen Beatrice Dogaru, Corina Muscurel and Irina Stoian
Int. J. Mol. Sci. 2025, 26(8), 3522; https://doi.org/10.3390/ijms26083522 - 9 Apr 2025
Viewed by 323
Abstract
Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD), represent a significant challenge to global health due to their progressive nature and the absence of curative treatments. These disorders are characterized by [...] Read more.
Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD), represent a significant challenge to global health due to their progressive nature and the absence of curative treatments. These disorders are characterized by oxidative stress, protein misfolding, and neuroinflammation, which collectively contribute to neuronal damage and death. Recent advancements in nanotechnology have introduced nanozymes—engineered nanomaterials that mimic enzyme-like activities—as promising therapeutic agents. This review explores the multifaceted roles of nanozymes in combating oxidative stress and inflammation in neurodegenerative conditions. By harnessing their potent antioxidant properties, nanozymes can effectively scavenge reactive oxygen species (ROS) and restore redox balance, thereby protecting neuronal function. Their ability to modify surface properties enhances targeted delivery and biocompatibility, making them suitable for various biomedical applications. In this review, we highlight recent findings on the design, functionality, and therapeutic potential of nanozymes, emphasizing their dual role in addressing oxidative stress and pathological features such as protein aggregation. This synthesis of current research underscores the innovative potential of nanozymes as a proactive therapeutic strategy to halt disease progression and improve patient outcomes in neurodegenerative disorders. Full article
(This article belongs to the Special Issue Targeting Oxidative Stress for Disease: 2nd Edition)
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