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Signaling Transduction in Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 2895

Special Issue Editors


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Guest Editor
Graduate Institute of Biomedical and Pharmaceutical Science, College of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan
Interests: signaling transduction; inflammation; antioxidants; anti-inflammation; neuroaging
Special Issues, Collections and Topics in MDPI journals
School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110301, Taiwan
Interests: signaling transduction; inflammation; cancer; antioxidants; anti-inflammation; anti-cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Signaling transduction stands at the core of maintaining cellular equilibrium. The intricate networks of communication within cells and their interactions with the extracellular environment demand a meticulous exploration of signaling mechanisms, spanning both macromolecular and nanoscale levels, to grasp their intricate workings. In recent decades, remarkable strides have been taken in this field, revealing a diverse spectrum of signaling mechanisms and their nuanced regulation within cells. These signaling pathways stretch from the extracellular milieu, traversing the plasma membrane, reaching various organelles, facilitating intra-organellar communication, and triggering specific cellular responses. This complexity underscores the necessity for a comprehensive investigation into signaling processes, illuminating their multifaceted roles in both health and disease. In particular, cytokines, chemokines, and endotoxins have been implicated in the pathogenesis of various inflammatory diseases, mediated through the activation of various intracellular signaling components and transcription factors, leading to the expression of inflammatory proteins such as cytokines, chemokines, adhesion molecules, etc. Through collaborative endeavors, our objective is to unravel the intricacies of signal transduction, offering profound insights that have the potential to revolutionize therapeutic strategies and advance human health. This Special Issue is dedicated to exploring signaling transduction in diverse cells and tissues, both in health and disease. These roles encompass a complex array of effects on gene expression modulation, profoundly impacting the development and progression of disorders in the endocrine, cardiovascular, respiratory, gastrointestinal, nervous, and immune systems, as well as various malignancies.

Dr. Chuen-Mao Yang
Dr. I-Ta Lee
Guest Editors

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Keywords

  • signaling pathways
  • inflammation
  • human disease
  • oxidative stress
  • neurodegeneration
  • heart disease
  • antioxidants

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Published Papers (1 paper)

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Review

14 pages, 257 KiB  
Review
Advances in DNA/RNA Sequencing and Their Applications in Acute Myeloid Leukemia (AML)
by Fatimah Ahmed and Jiang Zhong
Int. J. Mol. Sci. 2025, 26(1), 71; https://doi.org/10.3390/ijms26010071 - 25 Dec 2024
Cited by 2 | Viewed by 1342
Abstract
Acute myeloid leukemia (AML) is an aggressive malignancy that poses significant challenges due to high rates of relapse and resistance to treatment, particularly in older populations. While therapeutic advances have been made, survival outcomes remain suboptimal. The evolution of DNA and RNA sequencing [...] Read more.
Acute myeloid leukemia (AML) is an aggressive malignancy that poses significant challenges due to high rates of relapse and resistance to treatment, particularly in older populations. While therapeutic advances have been made, survival outcomes remain suboptimal. The evolution of DNA and RNA sequencing technologies, including whole-genome sequencing (WGS), whole-exome sequencing (WES), and RNA sequencing (RNA-Seq), has significantly enhanced our understanding of AML at the molecular level. These technologies have led to the discovery of driver mutations and transcriptomic alterations critical for improving diagnosis, prognosis, and personalized therapy development. Furthermore, single-cell RNA sequencing (scRNA-Seq) has uncovered rare subpopulations of leukemia stem cells (LSCs) contributing to disease progression and relapse. However, widespread clinical integration of these tools remains limited by costs, data complexity, and ethical challenges. This review explores recent advancements in DNA/RNA sequencing in AML and highlights both the potential and limitations of these techniques in clinical practice. Full article
(This article belongs to the Special Issue Signaling Transduction in Health and Disease)
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