Signaling Transduction in Health and Disease

Dear Colleagues,

Signaling transduction stands at the core of maintaining cellular equilibrium. The intricate networks of communication within cells and their interactions with the extracellular environment demand a meticulous exploration of signaling mechanisms, spanning both macromolecular and nanoscale levels, to grasp their intricate workings. In recent decades, remarkable strides have been taken in this field, revealing a diverse spectrum of signaling mechanisms and their nuanced regulation within cells. These signaling pathways stretch from the extracellular milieu, traversing the plasma membrane, reaching various organelles, facilitating intra-organellar communication, and triggering specific cellular responses. This complexity underscores the necessity for a comprehensive investigation into signaling processes, illuminating their multifaceted roles in both health and disease. In particular, cytokines, chemokines, and endotoxins have been implicated in the pathogenesis of various inflammatory diseases, mediated through the activation of various intracellular signaling components and transcription factors, leading to the expression of inflammatory proteins such as cytokines, chemokines, adhesion molecules, etc. Through collaborative endeavors, our objective is to unravel the intricacies of signal transduction, offering profound insights that have the potential to revolutionize therapeutic strategies and advance human health. This Special Issue is dedicated to exploring signaling transduction in diverse cells and tissues, both in health and disease. These roles encompass a complex array of effects on gene expression modulation, profoundly impacting the development and progression of disorders in the endocrine, cardiovascular, respiratory, gastrointestinal, nervous, and immune systems, as well as various malignancies.

Dr. Chuen-Mao Yang
Dr. I-Ta Lee
Guest Editors

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