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Pharmacological Activities of Secondary Metabolites and Derivates of Medicinal Plants Around the World, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 2649

Special Issue Editor


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Guest Editor
Medical Research Unit in Pharmacology, Speciality Hospital, National Medical Center Siglo XXI, Av. Cuauhtémoc 330 Col Doctores, México City CP 06725, Mexico
Interests: pharmacognosy of Mexican medicinal plants; diabetes mellitus; cancer; diarrhea; molecular docking; secondary metabolites
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Special Issue Information

Dear Colleagues,

Since ancient times, our ancestors have sought ways to remedy the ills and diseases that afflicted them by experimenting with the use of all kinds of substances, whether of plant, animal, or mineral origin. It is estimated that approximately between 64% and 80% of the world's population use medicinal plants to treat their health problems. In this sense, medicinal plants have been the source of many secondary metabolites to which numerous pharmacological activities have been attributed, in many cases giving rise to pharmacological treatments with important activity, which are currently used in therapeutics. Considering the above, the objective of this Special Issue is to encourage researchers to share their findings on medicinal plants from different regions of the world and the secondary metabolites isolated from them, with a focus on the search for new pharmacological treatments that can be applied to treat diseases that are of importance worldwide. Importantly, the exact active ingredient of the plant extract must be reported in the submitted research manuscript, since papers describing the effects of mixed extraction from plants will not be accepted.

This Special Issue is led by Dr. Fernando Calzada and assisted by our GE's Assistant Editor, Dr. Miguel Valdes (<valdesguevaramiguel@gmail.com>, Instituto Politécnico Nacional, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, México).

More published papers could be found in the closed Special Issue: Pharmacological Activities of Secondary Metabolites and Derivates of Medicinal Plants around the World.

Dr. Fernando Calzada
Guest Editor

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Keywords

  • natural products
  • secondary metabolites
  • medicinal chemistry
  • worldwide traditional medicine
  • isolation and identification of secondary metabolites
  • experimental studies
  • photochemistry
  • pharmacognosy
  • medicinal plants

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Published Papers (2 papers)

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Research

14 pages, 2366 KiB  
Article
The Potential of Plant Tissue Cultures to Improve the Steviol Glycoside Profile of Stevia (Stevia rebaudiana Bertoni) Regenerants
by Magdalena Dyduch-Siemińska, Karolina Wawerska and Jacek Gawroński
Int. J. Mol. Sci. 2024, 25(24), 13584; https://doi.org/10.3390/ijms252413584 - 19 Dec 2024
Viewed by 808
Abstract
The use of in vitro cultures in plant breeding allows for obtaining cultivars with improved properties. In the case of Stevia rebaudiana Bert., genotypes with an appropriate rebaudioside A/stevioside ratio are desirable. The use of indirect organogenesis allows for the induction of somaclonal [...] Read more.
The use of in vitro cultures in plant breeding allows for obtaining cultivars with improved properties. In the case of Stevia rebaudiana Bert., genotypes with an appropriate rebaudioside A/stevioside ratio are desirable. The use of indirect organogenesis allows for the induction of somaclonal variation, which, consequently, results in obtaining variability within the regenerants. The Murashige and Skoog medium containing 4.0 mg × dm−3 6-benzylaminopurine (BAP), 2.0 mg × dm−3 1-naphthaleneacetic acid (NAA), and 2.0 mg × dm−3 2,4-dichlorophenoxyacetic acid (2,4-D) resulted in obtaining plants that were biochemically and genetically diverse. The obtained regenerants were characterized by an increased content of rebaudioside A and a better rebaudioside A/stevioside ratio. Genetic analysis using SCoT (start-codon-targeted) markers showed their diversity at the molecular level. Moreover, this study showed that genotype multiplication through six subsequent re-cultures does not cause variability at the genotype level and does not affect the steviol glycoside profile. This study is the first report on obtaining genotypes with higher rebaudioside A content and a more attractive rebaudioside A to stevioside ratio through the use of in vitro cultures. The improved regenerants can be used as parents in hybridization programs or directly as valuable new genotypes. Full article
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24 pages, 7280 KiB  
Article
Caryophyllene Oxide, a Bicyclic Terpenoid Isolated from Annona macroprophyllata with Antitumor Activity: In Vivo, In Vitro, and In Silico Studies
by Jesica Ramírez-Santos, Fernando Calzada, Normand García-Hernández, Elizabeth Barbosa, Claudia Velázquez and Miguel Valdes
Int. J. Mol. Sci. 2024, 25(24), 13355; https://doi.org/10.3390/ijms252413355 (registering DOI) - 12 Dec 2024
Cited by 2 | Viewed by 972
Abstract
The Annona genus contains some species used in Mexican traditional medicine for the treatment cancer, including Annona macroprophyllata (A. macroprophyllata). The present study aimed to investigate the anticancer activity of caryophyllene oxide (CO) isolated from A. macroprophyllata using in vivo, in vitro, [...] Read more.
The Annona genus contains some species used in Mexican traditional medicine for the treatment cancer, including Annona macroprophyllata (A. macroprophyllata). The present study aimed to investigate the anticancer activity of caryophyllene oxide (CO) isolated from A. macroprophyllata using in vivo, in vitro, and in silico approaches. The identification of CO was performed using gas chromatography-mass spectroscopy and NMR methods. Antilymphoma activity was evaluated in male and female Balb/c mice inoculated with U-937 cells. Cytotoxic activity was evaluated using the WST method and flow cytometry was used to determine the type of cell death. Acute oral toxicity was determined, and a molecular docking study was performed using target proteins associated with cancer, including, HMG-CoA, Bcl-2, Mcl-1, and VEGFR-2. Results showed that CO exhibited significant antilymphoma and cytotoxic activities, and its effects were comparable to MTX. In addition, flow cytometry showed that the anticancer activity of CO could be mediated by the induction of late apoptosis and necrosis. The result for the acute oral toxicity of CO was classified in category 4, suggesting it is low risk. Finally, molecular coupling studies showed that CO had more affinity for the enzymes HMG-CoA reductase and Bcl-2. Our study provides evidences that CO is a potential anticancer agent for the treatment of histiocytic lymphoma. Full article
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