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Lipid Metabolism in Human Health and Diseases
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Lipid Metabolism in Human Health and Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 2221

Special Issue Editor

Dr. Arianna Vignini

E-Mail Website
Guest Editor
1. Department of Clinical Sciences, Polytechnic University of Marche, 60100 Ancona, Italy
2. Research Center of Health Education and Health Promotion, Università Politecnica delle Marche, 60100 Ancona, Italy
Interests: oxidative and nitrosative stress; bioactive compounds; NCDs; ageing; taste recognition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Lipids are organic compounds insoluble in water and soluble in organic solvents. They are the energy reserves of animals and accomplish different roles, ranging from maintaining body temperature, being the key constituents of cell membranes, and serving as chemical messengers, thus reflecting functions in the cell membranes, within the cytoplasm, and extracellularly. Balancing lipid levels in the blood is an important part of staying healthy. In recent years, with the increasing interest in lipid metabolism, more and more studies have shown that abnormal lipid metabolism is closely related to the occurrence and development of various human diseases, including cancer, cardiovascular, nervous system, and endocrine system diseases. Therefore, understanding how impairment in lipid metabolism can promote the development of such non-communicable diseases will offer a theoretical basis for their treatment and prevention and provide a new approach for the targeted treatments.

This Special Issue will focus on lipid metabolism in various human diseases, including cardiovascular diseases, neurodegenerative diseases, endocrine system diseases, cancer, and other diseases. Original research and review articles are particularly welcome.

Dr. Arianna Vignini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lipids
  • fatty acids
  • lipid metabolism
  • metabolic disorders
  • cardiovascular diseases
  • neurodegenerative diseases
  • cancers

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Published Papers (2 papers)

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Research

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18 pages, 2672 KiB  
Article
Newly Initiated Statin Treatment Is Associated with Decreased Plasma Coenzyme Q10 Level After Acute ST-Elevation Myocardial Infarction
by Erika Csengo, Hajnalka Lorincz, Eva Csosz, Andrea Guba, Bettina Karai, Judit Toth, Sara Csiha, Gyorgy Paragh, Mariann Harangi and Gergely Gyorgy Nagy
Int. J. Mol. Sci. 2025, 26(1), 106; https://doi.org/10.3390/ijms26010106 - 26 Dec 2024
Cited by 1 | Viewed by 1276
Abstract
Coenzyme Q10 (CoQ10) plays a crucial role in facilitating electron transport during oxidative phosphorylation, thus contributing to cellular energy production. Statin treatment causes a decrease in CoQ10 levels in muscle tissue as well as in serum, which may contribute to the musculoskeletal side [...] Read more.
Coenzyme Q10 (CoQ10) plays a crucial role in facilitating electron transport during oxidative phosphorylation, thus contributing to cellular energy production. Statin treatment causes a decrease in CoQ10 levels in muscle tissue as well as in serum, which may contribute to the musculoskeletal side effects. Therefore, we aimed to assess the effect of newly initiated statin treatment on serum CoQ10 levels after acute ST-elevation myocardial infarction (STEMI) and the correlation of CoQ10 levels with key biomarkers of subclinical or clinically overt myopathy. In this study, we enrolled 67 non-diabetic, statin-naïve early-onset STEMI patients with preserved renal function. Plasma CoQ10 level was determined by ultra-high-performance liquid chromatography–tandem mass spectrometry (UPLC/MS-MS), while the myopathy marker serum fatty acid-binding protein 3 (FABP3) level was measured with enzyme-linked immunosorbent assay (ELISA) at hospital admission and after 3 months of statin treatment. The treatment significantly decreased the plasma CoQ10 (by 43%) and FABP3 levels (by 79%) as well as total cholesterol, low-density lipoprotein cholesterol (LDL-C), apolipoprotein B100 (ApoB100), and oxidized LDL (oxLDL) levels. The change in CoQ10 level showed significant positive correlations with the changes in total cholesterol, LDL-C, ApoB100, and oxLDL levels, while it did not correlate with the change in FABP3 level. Our results prove the CoQ10-reducing effect of statin treatment and demonstrate its lipid-lowering efficacy but contradict the role of CoQ10 reduction in statin-induced myopathy. Full article
(This article belongs to the Special Issue Lipid Metabolism in Human Health and Diseases)
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Review

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20 pages, 1084 KiB  
Review
Neuroprotection vs. Neurotoxicity: The Dual Impact of Brain Lipids in Depression
by Yuting Yan, Yan Zhang, Mengting Liu, Lingjie Li and Yanrong Zheng
Int. J. Mol. Sci. 2025, 26(6), 2722; https://doi.org/10.3390/ijms26062722 - 18 Mar 2025
Viewed by 642
Abstract
Growing neurochemical evidence highlights cerebral lipid dysregulation as a key factor in the pathophysiology of major depressive disorder (MDD). This review systematically explores the dual roles of lipid species in both normal behavioral regulation and MDD development. By critically examining the recent literature, [...] Read more.
Growing neurochemical evidence highlights cerebral lipid dysregulation as a key factor in the pathophysiology of major depressive disorder (MDD). This review systematically explores the dual roles of lipid species in both normal behavioral regulation and MDD development. By critically examining the recent literature, we classify these lipid species into two functional categories based on their functional neuroactivity: (1) neuroprotective lipids (sphingomyelin, cholesterol, cardiolipin, sphingosine, phosphatidic acid, and phosphatidylserine), which exert neuroprotective effects by modulating membrane fluidity and supporting synaptic vesicle trafficking; and (2) neurotoxic lipids (ceramides, phosphatidylinositol, phosphocholine, and phosphatidylethanolamine), which promote apoptotic signaling cascades and disrupt mitochondrial bioenergetics. An unresolved but critical question pertains to the maintenance of homeostatic equilibrium between these opposing lipid classes. This balance is essential, given their significant impact on membrane protein localization and function, monoaminergic neurotransmitter metabolism, energy homeostasis, and redox balance in neural circuits involved in mood regulation. This emerging framework positions cerebral lipidomics as a promising avenue for identifying novel therapeutic targets and developing biomarker-based diagnostic approaches for MDD treatment. Full article
(This article belongs to the Special Issue Lipid Metabolism in Human Health and Diseases)
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