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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Natural and Synthetic Modified Nucleic Acids: Their Properties, Functions and Applications

edited by

Malgorzata Sierant

submission deadline 31 Dec 2026 | 3 articles | Viewed by 5900 | Submission Open

Keywords: DNA; RNA; nucleic acid analogues; modified nucleosides; modified nucleosides identification techniques; nucleoside modifying enzymes; gene therapy; therapeutic nucleic acids; biomedical applications; drug delivery

(This special issue belongs to the Section Molecular Biology)

Plant Adaptation to Abiotic Stresses: Evolutionary, Multi-Omics, and Molecular Perspectives

edited by

Guang Chen

and

Qiufang Shen

submission deadline 31 Dec 2026 | 5 articles | Viewed by 5810 | Submission Open

Keywords: plant; evolutionary adaptation; molecular evolution; abiotic stresses; stress tolerance; functional genomics; molecular regulatory network; genomics; transcriptomics; metabolomics; proteomics; epigenomics

(This special issue belongs to the Section Molecular Plant Sciences)

Osteoporosis: From Molecular Research to Novel Therapies

edited by

Agostino Gaudio

and Anastasia Xourafa

submission deadline 31 Dec 2026 | 2 articles | Viewed by 5805 | Submission Open

Keywords: osteoporosis; bone metabolism; OPG/RANK/RANKL system; Wnt/beta catenin signalling; secondary osteoporosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Sex Determination and Differentiation

edited by

Martin A. Estermann

submission deadline 31 Dec 2026 | 3 articles | Viewed by 5568 | Submission Open

Keywords: sex determination; sex differentiation; ovary; testis; epigenetics; gene regulatory networks; DSDs; transcriptomics; evolution

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Translational Insights in Neurological Disorders

edited by Tiago Santos

submission deadline 31 Dec 2026 | 5 articles | Viewed by 5555 | Submission Open

Keywords: neurological disorders; molecular mechanisms; translational neuroscience; drug targets; biomarkers; neurodegenerative disorders; neuroinflammatory conditions; demyelinating conditions; cerebrovascular conditions; neurodevelopmental disorders; mood disorders; anxiety disorders; spinal cord injury; traumatic brain injury; precision neurology; therapeutic development

(This special issue belongs to the Section Molecular Neurobiology)

Red Blood Cells: Dynamic Regulators, Disease Indicators and Therapeutic Targets

edited by Leonid Livshits

submission deadline 31 Dec 2026 | 1 articles | Viewed by 5027 | Submission Open

Keywords: red blood cell (RBC); RBC biochemical; hemodynamic; biophysical properties

(This special issue belongs to the Section Molecular Biology)

Current Insights into the Role of Exosomes in Intercellular Communication, 2nd Edition

edited by

Orit Uziel

submission deadline 31 Dec 2026 | 5 articles | Viewed by 4992 | Submission Open

Keywords: exosomes; extracellular vesicles; intracellular communication; intercellular communication

(This special issue belongs to the Section Molecular Biology)

The Interactions Between Nutrients and Adipose Tissue

edited by

Junseok Son

submission deadline 31 Dec 2026 | 5 articles | Viewed by 4818 | Submission Open

Keywords: adipose tissue; nutrients; metabolic health; insulin resistance; inflammation; energy homeostasis; adipokines; obesity; lipolysis; thermogenesis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cardiovascular and Metabolic Pharmacology

edited by

Alma Martelli

submission deadline 31 Dec 2026 | 2 articles | Viewed by 4666 | Submission Open

Keywords: cardiovascular pharmacology; metabolic pharmacology; hypertension; diabetes; obesity; atherosclerosis; hyperlipidemias; heart failure

(This special issue belongs to the Section Molecular Pharmacology)

The Role of Natural Products in Drug Discovery: 2nd Edition

edited by

Luciana Scotti

and

Marcus Tullius Scotti

submission deadline 31 Dec 2026 | 3 articles | Viewed by 4423 | Submission Open

Keywords: natural product; medicinal chemistry; drug design; drug discovery; pharmacy; chemistry

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Animal Molecular Genetics

edited by

Jarosław Króliczewski

submission deadline 31 Dec 2026 | 3 articles | Viewed by 4409 | Submission Open

Keywords: epigenetics; functional genomics; gene expression; gene polymorphism; genetic diseases; genetic techniques and assays; genome-wide association; genetic markers; quantitative genetics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Machine Learning Applications in Bioinformatics and Biomedicine: 4th Edition

edited by Hao Lv

submission deadline 31 Dec 2026 | 7 articles | Viewed by 4371 | Submission Open

Keywords: genome; transcriptome; proteome; metabolome; drug target; machine learning; prediction of drug side effects; epigenetic marker discovery for diseases; molecular network marker; early screening of diseases

(This special issue belongs to the Section Molecular Informatics)

Membrane Channels in Intercellular Communication

edited by

Camillo Peracchia

and

Jean Jiang

submission deadline 31 Dec 2026 | 3 articles | Viewed by 4259 | Submission Open

Keywords: gap junctions; connexins; innexins; channels; hemichannels; connexin mutations; channel gating; chemical gating; voltage gating; cell–cell coupling; cell-cell uncoupling; cell communication; intercellular communication; calcium; pH

(This special issue belongs to the Section Biochemistry)

Genomic-Defined Non-Small Lung Cancer (NSCLC) in the Real World: From Biology to Clinical Approaches

edited by

Eric Santoni-Rugiu

submission deadline 31 Dec 2026 | 2 articles | Viewed by 4257 | Submission Open

Keywords: genomic-defined NSCLC; molecular diagnostics; actionable targets; intrinsic resistance; acquired resistance

(This special issue belongs to the Section Molecular Oncology)

From DNA Damage to Cell Death: Emerging Drug Targets and Therapeutic Opportunities

edited by

Mateusz Kciuk

and Beata Marciniak

submission deadline 31 Dec 2026 | 2 articles | Viewed by 4254 | Submission Open

Keywords: apoptosis; cancer therapy; cell death pathways; chemoresistance; DNA damage response (DDR); DNA repair inhibitors; drug discovery; ferroptosis; genomic instability; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Human Virome and Emerging Viruses: Characterization, Interactions, and Molecular Insights

edited by

Luigi Rosa

and

Pietro Giorgio Spezia

submission deadline 31 Dec 2026 | 4 articles | Viewed by 4060 | Submission Open

Keywords: human virome; molecular virology; functional virology; metagenomics; virus–host interactions; immune modulation; pseudovirus assays; antiviral screening; omics integration; molecular immunology

(This special issue belongs to the Section Molecular Microbiology)

Advances in HIV Research: Molecular Basis and Potential Therapies

edited by

Sharilyn Almodovar

submission deadline 31 Dec 2026 | 1 articles | Viewed by 3860 | Submission Open

Keywords: human immunodeficiency virus; HIV prevention; HIV therapeutics; HIV vaccines; antiretroviral therapies; long-acting ART; HIV genetic therapy; HIV animal models; HIV in vitro models; viral reservoirs; HIV latency; HIV persistence; HIV evolution; HIV quasispecies; HIV proteins; HIV cure; HIV immunopathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biological Effects of Radiation on Human Cells and Tissues

edited by

Maria Paola Bertuccio

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3852 | Submission Open

Keywords: radiation exposure; molecular pathways; inflammation; immune response; biochemical markers; electromagnetic hypersensitivity

(This special issue belongs to the Section Molecular Biology)

Pulmonary Fibrosis: Molecular Mechanisms and Therapeutic Strategies

edited by

Barbara Ruaro

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3669 | Submission Open

Keywords: machine learning; pulmonary fibrosis; interstitial lung diseases; molecular mechanisms; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Stress-Activated Molecular Remodeling: Lipids, Chaperones, and the Cytoskeleton

edited by

Nikolas Nikolaidis

submission deadline 31 Dec 2026 | 4 articles | Viewed by 3521 | Submission Open

Keywords: cellular stress response; molecular remodeling; lipid signaling; membrane dynamics; cytoskeletal reorganization; chaperones; heat shock proteins; proteostasis; membrane–protein interactions; stress-induced trafficking; mechano-transduction; cell survival signaling

(This special issue belongs to the Section Molecular Biology)

Sex and Gender Medicine—Physiology: A New Horizon in Human Physiology

edited by

Rosanna Mallamaci

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3521 | Submission Open

Keywords: sex and gender; personalized medicine; sex-specific evidence; sex-specific differences

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional Proteomics: Insights from Biomedical Applications and Beyond

edited by

Elva Morretta

submission deadline 31 Dec 2026 | 1 articles | Viewed by 3514 | Submission Open

Keywords: functional proteomics; drug discovery; biomedicine; biomarker identification; protein molecular functions; pathway investigation

(This special issue belongs to the Section Molecular Immunology)

Flowers: Molecular and Genetic Regulation of Growth and Development

edited by Yaqin Wang

submission deadline 31 Dec 2026 | 4 articles | Viewed by 3479 | Submission Open

Keywords: flower; growth and development; molecular regulation; genetic breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Biotransformation and Engineering of Fungals and Microalgae

edited by

Alejandro Chamizo-Ampudia

submission deadline 31 Dec 2026 | 1 articles | Viewed by 3459 | Submission Open

Keywords: biotransformation pathways; metabolic engineering; bioactive compound synthesis; enzyme catalysis; microalgae–fungi synergy

(This special issue belongs to the Section Molecular Microbiology)

Roles of Non-Coding RNAs in Cancer

edited by Amit K. Mitra

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3252 | Submission Open

Keywords: lncRNA; miRNA; cancer; genomics; targeted therapy; biomarkers; drug resistance

(This special issue belongs to the Section Molecular Genetics and Genomics)

PPAR Update: Molecular Mechanisms and Therapeutic Perspectives

edited by

Naoki Tanaka

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3196 | Submission Open

Keywords: PPAR; PPARα; SPPARMα; pemafibrate; lipid metabolism; inflammation; fibrosis; nuclear receptor; translational research; precision medicine

(This special issue belongs to the Section Molecular Pharmacology)

Advances on Viral Immunology and Pathogenesis of Viral Infections

edited by Yeong-Bin Baek

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2947 | Submission Open

Keywords: viral immunology; viral pathogenesis; innate sensing and interferon; cytokine networks and inflammasomes; adaptive immunity (T- and B-cell quality); immunometabolism and lipid signaling; host-directed antiviral strategies; transcriptomics and spatial omics; mechanism of action and target engagement; complex bioactive modulators

(This special issue belongs to the Section Molecular Microbiology)

The Unresolved Molecular Bases of Major Histocompatibility Complex (MHC) Function with Transplantation and Diseases Linkage

edited by Antonio Arnaiz-Villena

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2899 | Submission Open

Keywords: HLA; disease; autoimmunity; immune deficiency; MHC phylogeny; HLA pharmacogenomics; immune modulatory MHC and HLA genes (G, E, F); transplantation; hemochromatosis; MHC/HLA epithelial interaction; MHC evolution; MHC phylogenetics; Vertebrate MHC; Amimal MHC; Veterinary

(This special issue belongs to the Section Molecular Immunology)

Oral Cancer: From Molecular Mechanisms to Therapeutics

edited by Diana Russo

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2879 | Submission Open

Keywords: oral cancer; molecular mechanisms; carcinogenesis; therapeutic strategies; biomarkers; immunotherapy; tumor microenvironment; drug resistance; precision medicine; head and neck oncology

(This special issue belongs to the Section Molecular Oncology)

Plant Breeding: Improvements and Applications of High-Yield, High-Quality and Stress-Resistant Genetic Traits

edited by Juwu Gong

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2654 | Submission Open

Keywords: plant breeding; crop genetic improvement; gene editing; stress resistance; crop quality; crop yield; gene resource utilization

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms in Heart Rate Regulation and Cardiac Arrhythmias

edited by Yingjie Liu

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2604 | Submission Open

Keywords: cardiac arrhythmias; heart rate regulation; molecular mechanisms; intrinsic regulation; neurohumoral regulation; arrhythmia development; treatment strategies

(This special issue belongs to the Section Molecular Biology)

Updates on Synthetic and Natural Antioxidants (2nd Edition)

edited by

Izabela Sadowska-Bartosz

and

Grzegorz Bartosz

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2576 | Submission Open

Keywords: antioxidants; synthetic; natural compounds

(This special issue belongs to the Section Biochemistry)

Advances in Antimicrobial Agents and Resistance Mechanisms

edited by

Julieta Luna-Herrera

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2568 | Submission Open

Keywords: acquired resistance; antibiotic inactivation; antibiotic modifications; antibiotic uptake; antibiotics; antimicrobial agents; bacterial dormancy; efflux pumps; extrachromosomal elements; genomic mutations; novel antimicrobial molecules; resistant mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Upper and Lower Airway Diseases in Allergy and Immunology: From Bench to Bedside

edited by

Giovanni Paoletti

Giulia Costanzo

and

Enrico Marco Heffler

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2555 | Submission Open

Keywords: unified airway disease; allergic rhinitis; asthma; chronic rhinosinusitis; eosinophilic; airway inflammation; airway epithelial barrier; immune dysregulation; respiratory microbiome; biomarkers; allergy and immunology

(This special issue belongs to the Section Molecular Immunology)

Canonical and Noncanonical Inflammasomes in Inflammation and Diseases

edited by

Young-Su Yi

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2530 | Submission Open

Keywords: canonical; noncanonical; inflammasome; inflammation; human diseases; anti-inflammatory therapeutics

(This special issue belongs to the Section Molecular Immunology)

Bioactive Compounds in the Prevention of Chronic Diseases: 2nd Edition

edited by

Diego A. Moreno

Antonio J. Ruiz-Alcaraz

and

Paola Maycotte

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2505 | Submission Open

Keywords: bioactives; chronic disease; inflammation; oxidative stress; obesity; diabetes; cancer

(This special issue belongs to the Section Bioactives and Nutraceuticals)

ROS and Abiotic Stress in Plants, 3rd Edition

edited by

Tsanko S. Gechev

and

Veselin Petrov

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2483 | Submission Open

Keywords: chilling and freezing; drought stress; heat stress; heavy metals stress; nutrient and mineral stress; oxidative stress; resurrection plants and desiccation tolerance; salinity

(This special issue belongs to the Section Molecular Plant Sciences)

Autosomal Dominant Polycystic Kidney Disease (ADPKD): Molecular Mechanism, Management and Therapy

edited by

Maria Teresa Sciarrone Alibrandi

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2476 | Submission Open

Keywords: autosomal dominant polycystic kidney disease; ADPKD progression; cystic kidney disease; cardiovascular complications in ADPKD; biomarkers of ADPKD; genetics of polycystic kidney disease; renal imaging; targeted therapies in ADPKD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research in Nanotechnology for Natural Products

edited by

Carmen Lizette Del Toro Sánchez

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2433 | Submission Open

Keywords: molecular nanotechnology; natural products; bioactive compounds; nanocarriers; targeted delivery; encapsulation; bioavailability; pharmacological applications; food applications; biomedical nanotechnology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Insights into the Structure and Function of Nuclear Receptors

edited by

Elza Fonseca

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2333 | Submission Open

Keywords: transcription factors; endocrine disorders; ligands; xenobiotics; pharmacology; modelling; drug design; evolution; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Lectins: Structural Diversity, Molecular Recognition and Emerging Applications

edited by

Patrícia Maria Guedes Paiva

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2071 | Submission Open

Keywords: lectins; structural diversity; molecular recognition; bioactivities; biomedical applications

(This special issue belongs to the Section Biochemistry)

Molecular Advances in the Pathophysiology and Therapy of Cerebral Gliomas

edited by

Placido Bruzzaniti

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2060 | Submission Open

Keywords: mutant IDH1 3; EVs; Ki67; HSV1-TK; glioma; lipid vesicles; viral vectors; ATRX; EGFR; IDH1; MGMT; 1p/19q codeletion

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms in Cardiovascular Disease Progression

edited by Ying-Hsi Lin

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1957 | Submission Open

Keywords: cardiovascular disease progression; molecular mechanisms; inflammation; signal transduction; transcriptional and epigenetic regulation; mitochondrial dysfunction; sarcomeric remodeling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Coronavirus Disease (COVID-19): Pathophysiology (7th Edition)

edited by

Malgorzata Kloc

and Jacek Kubiak

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1939 | Submission Open

Keywords: SARS-CoV-2; coronavirus; pandemic; viral diseases; pediatrics; inflammation; immune cells; macrophages; pneumonia; vaccines; cytokines; cytokine storm; PIMS; immunity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Sellar Region Tumors: New Insights in Their Pathogenesis, Diagnosis and Treatment

edited by

Dimitrios Kanakis

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1918 | Submission Open

Keywords: sellar region tumors; pituitary neuroendocrine tumors (PitNETs); neurohypophyseal tumors; hypothalamic neoplasms; craniopharyngiomas; germ cell tumors; meningiomas; Rathke cleft cysts; chordomas

(This special issue belongs to the Section Molecular Oncology)

Application and Molecular Mechanisms of Microwaves for Materials Processing

edited by

Valentin Craciun

and

Marian Mogildea

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1883 | Submission Open

Keywords: microwaves; non-ionizing radiation; molecular materials characterizations; molecular materials synthesis; microwave processing and engineering

(This special issue belongs to the Section Materials Science)

Molecular and Translational Mechanisms of Cardiac Arrhythmias: From Oxidative Stress to Novel Therapeutic Strategies

edited by

Stefan Simović

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1878 | Submission Open

Keywords: cardiac arrhythmias; atrial fibrillation; oxidative stress; molecular mechanisms; translational research; antiarrhythmic therapy; cardiac remodeling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Natural Products: Redox Balance, Inflammation Control, and Apoptosis Modulation

edited by Rosanna Avola

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1877 | Submission Open

Keywords: natural antioxidants; inflammation; apoptosis; bioactive natural products; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms Linking Obesity to Atherosclerosis Pathogenesis

edited by

Weibin Shi

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1827 | Submission Open

Keywords: obesity; overweight; atherosclerosis; coronary artery disease; obesity paradox; body mass index; visceral fat

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Perspectives in Tissue Engineering and Regenerative Medicine

edited by

Sorina Dinescu

submission deadline 31 Dec 2026 | 1 articles | Viewed by 1778 | Submission Open

Keywords: 3D scaffolds; personalized regenerative therapies; tissue engineering; stem cells; bone regeneration; regenerative biomarkers; cell–scaffold interactions; nanomaterials

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 1851-1900 on page 38 of 61.

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