Genomic-Defined Non-Small Lung Cancer (NSCLC) in the Real World: From Biology to Clinical Approaches

Dear Colleagues,

Mounting data indicate that the outcome of real-world patients with advanced NSCLC harboring genomic alterations is worse than that reported in randomized clinical studies. With this Special Issue, we would like to emphasize real-world data on NSCLC patients with genomic driver alterations.

The treatment landscape for these patients is constantly changing. Advances in understanding the biology of NSCLC with defined druggable targets are based not only on well-tailored diagnostics, but also on recognizing the importance of molecular co-alterations that may shape the disease course. All this is happening at a time when new promising treatments are emerging; however, it is not always clear which patients may benefit from them, and which have intrinsically resistant tumors. Additionally, disease progression due to acquired resistance requires an individualized approach based on tissue rebiopsies and/or liquid biopsies as well as clinical features.

Thus, in this Special Issue (led by Prof. Dr. Eric Santoni-Rugiu, with the assistance of Dr. Edyta Maria Urbanska from Copenhagen University Hospital), we would like to highlight the challenges in understanding, diagnosing and treating genomic-defined NSCLC in the real world and encourage molecular biologists, pathologists, and clinicians to share their experiences.

With this Special Issue of IJMS, contributions in the form of original research articles, short communications, reviews, and case reports are welcomed.

Prof. Dr. Eric Santoni-Rugiu
Guest Editor

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