Cardiovascular and Metabolic Pharmacology

Dear Colleagues,

Despite their broad pharmacological platform, cardiovascular and metabolic diseases remain the leading causes of morbidity and mortality worldwide. Curative therapies for these conditions remain inadequate to meet medical needs, likely due to their complex pathophysiology involving closely interconnected molecular mechanisms. This Special Issue brings together original research and comprehensive reviews exploring the molecular basis of cardiovascular and metabolic diseases, including hypertension, atherosclerosis, heart failure, diabetes, hyperlipidemias and obesity. Emphasis is placed on novel drug targets, such as noncoding RNAs, ion channels, metabolic enzymes, and inflammatory mediators, as well as emerging therapeutic strategies involving gene editing, small molecules, and biologics. By focusing on molecular mechanisms, this Special Issue bridges the gap between basic science and clinical application. We also emphasize the importance of systems biology and multi-omics approaches in unraveling the complexity of diseases and the variability in drug response. Recent advances in molecular pharmacology have shed new light on the signaling pathways, genetic regulators, and metabolic networks underlying disease development and progression. This Special Issue also uncovers novel molecular mechanisms that could potentially advance the prevention and management of cardiovascular and metabolic diseases in the era of personalized medicine.

Dr. Alma Martelli
Guest Editor

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