Autosomal Dominant Polycystic Kidney Disease (ADPKD): Molecular Mechanism, Management and Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 20
Special Issue Editor
Interests: ADPKD; genetically determined cystic diseases; hereditary kidney disorders; arterial hypertension; electrolyte and acid-base imbalances
Special Issue Information
Dear Colleagues,
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common inherited kidney disorder and a leading cause of end-stage renal disease (ESRD) worldwide. Despite the significant progress made in understanding the genetic and molecular mechanisms behind ADPKD, many aspects of its pathogenesis, progression, and clinical management remain incompletely understood. This has limited the development of targeted therapies and effective disease-modifying treatments.
ADPKD is characterized by the progressive formation and enlargement of kidney cysts, which lead to renal function decline and a wide range of extrarenal manifestations. Early diagnosis, personalized risk stratification, and novel treatment approaches are essential to improving the long-term outcomes for patients.
A key component of comprehensive ADPKD management is the assessment and prevention of cardiovascular complications. Left ventricular hypertrophy, hypertension, and intracranial aneurysms are just some of the potential manifestations. Therefore, early cardiovascular screening and risk stratification play a pivotal role in improving patient prognosis and guiding timely therapeutic interventions.
This Special Issue aims to collect high-quality original research articles and comprehensive reviews that provide new insights into the pathophysiology, diagnosis, management, and treatment of ADPKD. We welcome submissions of novel findings that are not under consideration elsewhere and contribute meaningfully to the advancement of the field.
Potential topics include, but are not limited to, the following:
- The molecular and genetic mechanisms driving ADPKD progression;
- Novel diagnostic and prognostic biomarkers;
- Advances in imaging techniques for disease monitoring;
- Emerging therapeutic strategies and clinical trials;
- Role of inflammation, metabolism, and fibrosis in ADPKD;
- Experimental models of ADPKD;
- The impact of lifestyle and dietary interventions;
- Cardiovascular complications and the importance of screening;
- Extra-renal manifestations and systemic involvement;
- Patient-centered care and long-term follow-up strategies;
- Translational research and precision medicine approaches in ADPKD.
We look forward to your contributions to this Special Issue.
Dr. Maria Teresa Sciarrone Alibrandi
Guest Editor
Manuscript Submission Information
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Keywords
- autosomal dominant polycystic kidney disease
- ADPKD progression
- cystic kidney disease
- cardiovascular complications in ADPKD
- biomarkers of ADPKD
- genetics of polycystic kidney disease
- renal imaging
- targeted therapies in ADPKD
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