Sellar Region Tumors: New Insights in Their Pathogenesis, Diagnosis and Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 11
Special Issue Editor
Interests: neurooncology; neurodegenerative diseases; traumatic brain injury/chronic traumatic encephalopathy; demyelinating diseases; neurodevelopmental disorders; neuromuscular disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Sellar and parasellar tumors comprise a clinically important group of lesions, including hypophyseal tumors of the anterior lobe (i.e., pituitary neuroendocrine tumors [PitNETs]), posterior lobe tumors, hypothalamic neoplasms, craniopharyngiomas, meningiomas, germ cell tumors, Rathke cleft cyst-associated lesions, chordomas, metastases, and other rare entities. The involvement of important structures, like the optic apparatus, hypothalamus, cavernous sinus, pituitary gland, and major vascular structures, creates major diagnostic and therapeutic challenges.
This Special Issue aims to gather high-quality contributions addressing new developments in the pathogenesis, diagnosis, and management of sellar region tumors. Particular interest will be given to studies exploring genetic, epigenetic, transcriptional, immunologic, and microenvironmental mechanisms that influence tumor initiation, invasion, recurrence and endocrine dysfunction. We welcome submissions focused on improved diagnostic strategies, including genomic, epigenomic, transcriptomic, proteomic, and metabolomic approaches, tumor-derived molecular signatures, circulating biomarkers, histopathological refinements, and integrated endocrine, ophthalmologic, and neurosurgical assessment. Therapeutic innovation is another central theme. Topics may include molecularly guided therapeutic stratification, targeted pathway inhibition, epigenetic therapies, peptide receptor radionuclide therapy, immunotherapeutic approaches, proton therapy, medical treatment of functioning pituitary tumors, management of aggressive or refractory pituitary neuroendocrine tumors, and emerging systemic therapeutic options.
Original research, translational studies, clinical trials, systematic reviews, imaging–pathology correlations, and expert perspectives are invited. By bringing together endocrinologists, neurosurgeons, neuroradiologists, neuropathologists, radiation oncologists, oncologists, ophthalmologists, and basic scientists, this Research Topic seeks to advance precision care and improve outcomes for patients with sellar region tumors.
We look forward to receiving your contributions.
Prof. Dr. Dimitrios Kanakis
Guest Editor
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Keywords
- sellar region tumors
- pituitary neuroendocrine tumors (PitNETs)
- neurohypophyseal tumors
- hypothalamic neoplasms
- craniopharyngiomas
- germ cell tumors
- meningiomas
- Rathke cleft cysts
- chordomas
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