PPAR Update: Molecular Mechanisms and Therapeutic Perspectives
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 16
Special Issue Editor
Interests: metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); nutrient metabolism; PPAR; nutritional intervention; hepatic fibrosis; hepatocarcinogenesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue, “PPAR Update: Molecular Mechanisms and Therapeutic Perspectives”, aims to highlight recent advances in the biology, pharmacology, and translational research of peroxisome proliferator-activated receptor (PPAR). PPARs are key nuclear receptors involved in lipid metabolism, inflammation, and organ protection across the liver, heart, kidney, and other systems. With the emergence of selective PPARα modulators (SPPARMα), such as pemafibrate, novel insights have been gained into ligand selectivity, tissue-specific regulation, and therapeutic applications.
This Special Issue welcomes original research articles and reviews that explore molecular mechanisms, omics-based profiling, structural and computational studies, inter-organ crosstalk, and clinical implications of PPAR signaling. By integrating findings from basic to clinical sciences, this collection aims to provide an updated and comprehensive overview of the evolving field of PPAR biology and its potential for precision medicine.
Prof. Dr. Naoki Tanaka
Guest Editor
Manuscript Submission Information
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Keywords
- PPAR
- PPARα
- SPPARMα
- pemafibrate
- lipid metabolism
- inflammation
- fibrosis
- nuclear receptor
- translational research
- precision medicine
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