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Bioactive Compounds in the Prevention of Chronic Diseases: 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 December 2026 | Viewed by 848

Special Issue Editors


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Guest Editor
Research Group "Laboratorio de Fitoquímica y Alimentos Saludables" (LabFAS), CSIC, CEBAS, Campus Universitario de Espinardo, E-30100 Murcia, Spain
Interests: phytochemicals; inflammation; obesity; health-centered agri-foods
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Guest Editor
Department of Biochemistry, Molecular Biology B and Immunology, School of Medicine, University of Murcia, Regional Campus of International Excellence “Campus Mare Nostrum”, 30100 Murcia, Spain
Interests: Inmune response; inflammation; immunonutrition; chronic diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In order to resolve the need for a balanced and varied diet that is rich in bioactive compounds to combat the rising incidence of diseases such as obesity, diabetes, cardiovascular diseases, cancer, and osteoporosis, we are interested in breakthrough experimental and technical progress of broad interest in biology, chemistry, and medicine on “Bioactive Compounds in the Prevention of Chronic Diseases”.

Bioactive compounds and their known metabolites including, but not limited to, polyphenols, fatty acids, proteins, dietary fibers, etc., play a crucial role in modulating inflammation and oxidative stress, which are key factors in chronic disease development. Additionally, the search for safer and more effective therapeutics for life-threatening diseases like cancer, diabetes, and cardiovascular diseases is ongoing. We encourage authors to focus on results at the molecular level and to submit their contributions to help the scientific community and society by extension to fully understand the effectiveness of the bioactive compounds in disease management.

Dr. Diego A. Moreno
Prof. Dr. Antonio J. Ruiz-Alcaraz
Dr. Paola Maycotte
Guest Editors

Manuscript Submission Information

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Keywords

  • bioactives
  • chronic disease
  • inflammation
  • oxidative stress
  • obesity
  • diabetes
  • cancer

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Published Papers (1 paper)

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Research

19 pages, 1540 KB  
Article
Strong Antiproliferative Activity Observed in Hammett-Guided Electronic Modulation of GPx-Mimetic Pathways in Aryl Selenoureas
by Paloma Begines, Clara I. Pérez-Lage, Adrián Puerta, José M. Padrón, Óscar López and José G. Fernández-Bolaños
Int. J. Mol. Sci. 2026, 27(8), 3574; https://doi.org/10.3390/ijms27083574 - 16 Apr 2026
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Abstract
Organoselenium chemistry has undergone remarkable development over the past five decades, evolving from its initial association with high toxicity into a field with pivotal contributions to materials science, organic synthesis, catalysis, and Medicinal Chemistry. Among the diverse biological activities displayed by organoselenium compounds, [...] Read more.
Organoselenium chemistry has undergone remarkable development over the past five decades, evolving from its initial association with high toxicity into a field with pivotal contributions to materials science, organic synthesis, catalysis, and Medicinal Chemistry. Among the diverse biological activities displayed by organoselenium compounds, their redox behaviour is particularly compelling, as many of these molecules act as efficient mimetics of the antioxidant enzyme glutathione peroxidase (GPx). In this work, we investigated the GPx-like activity of a series of N,N′-diaryl selenoureas toward the depletion of H2O2 and cumene hydroperoxide (CumOOH) as model ROS. Their reactivity was correlated with the electronic nature of the aryl substituents using a Hammett-type analysis, revealing a strong dependence of the reaction rate on remote electronic perturbations within the aromatic ring. Combined UV and NMR studies provided mechanistic evidence supporting a catalytic cycle in which selenoureas, operating at sub-stoichiometric loadings (1 mol%) and using a thiol as a cofactor-like molecule, can be used to efficiently scavenge ROS with half-lives of only a few minutes (~10–60 min). Furthermore, these selenoureas exhibited potent antiproliferative activity across several human solid tumour cell lines. Overall, these results offer mechanistic insight into the ROS-eliminating pathways of selenoureas and highlight their potential as chemopreventive or anticancer agents. Full article
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