Stress-Activated Molecular Remodeling: Lipids, Chaperones, and the Cytoskeleton
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 37
Special Issue Editor
Interests: heat shock response; membrane-associated heat shock proteins; protein–lipid interactions
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cells respond to acute and chronic stress through the rapid and coordinated remodeling of key molecular systems, including membranes, cytoskeletal networks, and protein homeostasis machinery. This Special Issue will focus on the dynamic interplay between lipid signaling, cytoskeletal reorganization, and chaperone activity during cellular stress responses, particularly emphasizing their implications for human health and disease. We welcome studies that investigate how stress triggers changes in membrane composition, lipid–protein interactions, cytoskeletal architecture, and proteostasis—and how these processes contribute to pathological conditions such as cancer, neurodegeneration, infection, and inflammatory disorders. By highlighting emerging research on the crosstalk between structural and functional elements of stressed cells, this Special Issue aims to bridge basic molecular mechanisms with translational insights, bringing together perspectives from biochemistry, cell biology, biophysics, and disease modeling.
We invite original research articles and reviews exploring how cells dynamically remodel molecular systems in response to stress. This Special Issue focuses on the interplay between lipid signaling, membrane dynamics, cytoskeletal reorganization, and chaperone function, and how these processes contribute to cellular adaptation, survival, and disease. Submissions with mechanistic insights or translational relevance to conditions such as cancer, neurodegeneration, infection, or inflammation are especially welcome.
Topics include (but are not limited to) the following:
- Membrane and lipid remodeling under stress;
- Chaperone function and proteostasis;
- Cytoskeletal dynamics and mechano-signaling;
- Membrane–protein interactions and trafficking;
- Stress responses in human disease models.
Prof. Dr. Nikolas Nikolaidis
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cellular stress response
- molecular remodeling
- lipid signaling
- membrane dynamics
- cytoskeletal reorganization
- chaperones
- heat shock proteins
- proteostasis
- membrane–protein interactions
- stress-induced trafficking
- mechano-transduction
- cell survival signaling
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
