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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Locus Coeruleus in Regulating Sudden Cortical States and Preventing Neurodegeneration

edited by

Francesco Fornai

submission deadline 20 Feb 2026 | Viewed by 235 | Submission Open

Keywords: reticular formation; norepinephrine; neuroplasticity; neuroprotection; neurodegenerations; adrenergic receptors; dementia; parkinson's disease; autism; affective disorders; addiction; psychostimulants

(This special issue belongs to the Section Molecular Neurobiology)

Purine Signaling as a Therapeutic Target in Human Diseases

edited by

Aránzazu Mediero

submission deadline 20 Feb 2026 | Viewed by 233 | Submission Open

Keywords: disease; adenosine; ATP; receptors; transporters; therapeutics; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

Drug Development and Discovery for Alzheimer's Disease

edited by Martha Cecilia Rosales-Hernández

submission deadline 20 Feb 2026 | Viewed by 232 | Submission Open

Keywords: Alzheimer's disease; drug design; repurposed molecules; therapeutic targets; amyloid-β ; β -secretase; acetylcholin-esterase; in silico studies; oxidative stress; chemical synthesis

(This special issue belongs to the Section Molecular Neurobiology)

The Application of Large Language Model and Agents in Molecular Medicine and Molecular Biology

edited by

Hao Lin

and Hao Lv

submission deadline 20 Feb 2026 | Viewed by 231 | Submission Open

Keywords: large language models; artificial intelligence; agents; biological data; medical data

(This special issue belongs to the Section Molecular Informatics)

Health Targeting Cardiovascular and Cerebrovascular Diseases: Molecular Aspects

edited by

Byeong-Wook Song

submission deadline 20 Feb 2026 | Viewed by 228 | Submission Open

Keywords: cardiovascular disease; cerebrovascular disease; cell therapy; gene therapy; extracellular vesicles; regenerative medicine; brain– heart axis; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pain: From Bench to Bedside

edited by

Christopher Robinson

and Robert J. Yong

submission deadline 20 Feb 2026 | Viewed by 226 | Submission Open

Keywords: CGRP pathway; chronic pain; drug discovery; ion channels; machine learning; molecular targets; neuroimmune signaling; non-opioid analgesics; translational pain research TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in English Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Natural Product Synthesis and Emerging Biotechnology Applications

edited by Katarzyna Kotwica-Mojzych

submission deadline 20 Feb 2026 | Viewed by 224 | Submission Open

Keywords: natural compounds; natural product synthesis; chemical analysis; molecular technologies; biotechnology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Acute Myeloid Leukemia: From Molecular Insights to Therapeutic Innovations

edited by

Lukasz Szymanski

submission deadline 20 Feb 2026 | Viewed by 223 | Submission Open

Keywords: acute myeloid leukemia; AML; epigenetic Mechanisms; genetics; epigenetic regulation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Metal-Organic Frameworks: Pioneering New Solutions for Biomedical Challenges

edited by

David Rodríguez-Lucena

and

Belén Begines

submission deadline 20 Feb 2026 | Viewed by 215 | Submission Open

Keywords: MOFs; biomedical advances; drug delivery; personalized medicine; biomedical imaging; bio-sensor; smart MOFs; nanomedicine; cancer therapy

(This special issue belongs to the Section Materials Science)

Nanotechnology for Food Science—Innovations and Sustainable Solutions

edited by

Nan Cheng

submission deadline 20 Feb 2026 | Viewed by 205 | Submission Open

Keywords: nanotechnology; nanomaterial synthesis; food safety; food science; nano-engineered food additives; nano-sensors

(This special issue belongs to the Section Molecular Nanoscience)

Exosomes in the Processes of Tumorigenesis, Cancer Progression, Metastasis, and Treatment

edited by

Foteinos-Ioannis Dimitrakopoulos

submission deadline 20 Feb 2026 | Viewed by 205 | Submission Open

Keywords: exosomes; extracellular vesicles; metastasis; cancer; prognosis; prediction; biomarker; cancer treatment

(This special issue belongs to the Section Molecular Oncology)

Development Biology of Immune Cells

edited by Jacek Z. Kubiak

submission deadline 20 Feb 2026 | Viewed by 203 | Submission Open

Keywords: immune cell development; macrophages; monocytes; B-cells; T-cells; dendritic cells; NK cells

(This special issue belongs to the Section Molecular Immunology)

Roles of Exosomes in Health and Disease

edited by

Paulo Pereira

submission deadline 20 Feb 2026 | Viewed by 201 | Submission Open

Keywords: exosomes; extracellular vesicles; intercellular communication; diagnostics; therapeutics; disease; biomarkers; cellular biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Products: Potential Anti-Inflammatory or Anti-Oxidative Mechanisms

edited by

Dong-Sung Lee

and

Chi-Su Yoon

submission deadline 20 Feb 2026 | Viewed by 198 | Submission Open

Keywords: inflammation; neuroinflammation; neurodegenerative disease; skin inflammation; skin disease; antioxidants; natural products; secondary metabolites

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of the Gut and Oral Microbiota in Neurodevelopment: Molecular Biological Insights

edited by Ioannis Alexandros Charitos

submission deadline 20 Feb 2026 | Viewed by 198 | Submission Open

Keywords: neuroscience; central nervous system; peripheral nervous system; human microbiota; metabolome; gut– oral-microbiota– brain axis; neurodevelopment disorders; cognitive modulation; neurodegenerative diseases; psychobiotics

(This special issue belongs to the Section Molecular Microbiology)

Development and Applications of Biodegradable and Bioactive Materials

edited by

Mercedes Ana Peltzer

submission deadline 20 Feb 2026 | Viewed by 194 | Submission Open

Keywords: biopolymers; bioplastics; sustainability; food packaging; medicine and cosmetic; bioactive compounds; wound healing; active and intelligent packaging

(This special issue belongs to the Section Materials Science)

Electron or Ion Transport in Electrochemistry

edited by Simone Sanna

submission deadline 20 Feb 2026 | Viewed by 191 | Submission Open

Keywords: solid oxide fuel cells; mixed ionic and electronic conductors; perovskite; fluorite; hydrogen; CO2 reduction; water splitting; energy conversion and storage

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Theranostic Application of Reactive Oxygen Species-Sensitive Nanocarriers

edited by

Young-Il Jeong

submission deadline 20 Feb 2026 | Viewed by 190 | Submission Open

Keywords: ROS generation; ROS detection; ROS-sensitive nanoparticles; Photodynamic therapy (PDT)

(This special issue belongs to the Section Molecular Nanoscience)

Contribution of Astrocytes and Microglia for the Development of Neurological Disorders

edited by

Rommy Von Bernhardi

submission deadline 20 Feb 2026 | Viewed by 188 | Submission Open

Keywords: aging; astrocytes; glial cells; microglia; neurodegenerative diseases; neuron-glia interaction; neuroimmune response; neuroinflammation

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Advances of Layered Double Hydroxides (LDH) for Corrosion Protection

edited by

Henryk Kania

submission deadline 20 Feb 2026 | Viewed by 188 | Submission Open

Keywords: layered double hydroxide (LDHs); corrosion resistance; coatings; corrosion products

(This special issue belongs to the Section Materials Science)

Advanced Research in Immune Cell Therapy

edited by

Alexander Huang

submission deadline 20 Feb 2026 | Viewed by 187 | Submission Open

Keywords: molecular biology; bioinformatics; proteomics; molecular mechanisms; genomics

(This special issue belongs to the Section Molecular Immunology)

New Advances in Plant Genetic Research

edited by

Ming Chen

submission deadline 20 Feb 2026 | Viewed by 186 | Submission Open

Keywords: plant generative genomics; plant– microbe interaction gene-editing; single-cell omics in plants; plant non-coding RNAs; AI in plant science

(This special issue belongs to the Section Molecular Plant Sciences)

NURR1 Biology in Neurological Disorders and Other Diseases

edited by

Ángel Juan García-Yagüe

submission deadline 20 Feb 2026 | Viewed by 184 | Submission Open

Keywords: NURR1; regulation; chronic diseases; inflammation; neurodegenerative diseases; neurological diseases; cancer; inflammatory diseases

(This special issue belongs to the Section Molecular Biology)

From Pathogenic Mechanisms to Therapy in Retinal Diseases

edited by

Nan-Kai Wang

and

Eugene Yu Chuan Kang

submission deadline 20 Feb 2026 | Viewed by 181 | Submission Open

Keywords: retinal degeneration; oxidative stress; angiogenesis; mitochondria; cellular metabolism; genetic disorders and gene therapy; genes; age-related macular degeneration; inherited retinal dystrophy; diabetic retinopathy; retinal ganglion cells; photoreceptors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cellular Pathways and Cytokine Networks in Tuberous Sclerosis: Mechanisms and Therapeutic Targets

edited by Uchenna John Unachukwu

submission deadline 20 Feb 2026 | Viewed by 175 | Submission Open

Keywords: mTOR signaling dysregulation; neurocristopathy; cytokine crosstalk; TSC1/TSC2 complex; epigenetic modifiers; metabolic reprogramming; molecular biomarkers; spatial transcriptomics

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Antiviral Agents and Antiviral Therapy

edited by

Jesus Alberto Silvas

submission deadline 20 Feb 2026 | Viewed by 173 | Submission Open

Keywords: therapeutics; high-throughput screening; viral reverse genetics; luciferase; fluorescent; compound; repurpose; antiviral; diagnostics

(This special issue belongs to the Section Molecular Immunology)

Nutrition from Cereal Foods: Molecular Insights into Nutrition, Metabolism and Health Regulation

edited by Genyi Zhang

submission deadline 20 Feb 2026 | Viewed by 173 | Submission Open

Keywords: molecular breeding; cereal crops; bioactive compounds; metabolic syndrome; inflammation; gut health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Age-Dependence of Neuroimmune Reactions

edited by

Babak Baban

submission deadline 20 Feb 2026 | Viewed by 172 | Submission Open

Keywords: age; neuroimmune dynamics; neuroimmune interaction; immune system; the central nervous system; age-related neuroinflammation; neurodegenerative diseases

(This special issue belongs to the Section Molecular Immunology)

Natural Compounds in Cancer: Targeting Immune Cells and Signalling Pathways

edited by

Tomasz Jędrzejewski

submission deadline 20 Feb 2026 | Viewed by 168 | Submission Open

Keywords: natural compounds; cancer; inflammation; signalling pathways; antineoplastic agents; macrophage; T cells; molecular mechanism of pharmacological action; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Electrochemistry and Emerging Contaminants: Molecular Insights for Innovative Solutions

edited by

Miguel A. Esteso

submission deadline 20 Feb 2026 | Viewed by 163 | Submission Open

Keywords: electrochemistry; chemical reactions; removal; environmental pollution

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Plasticity in Multiple Sclerosis: From Molecular to System Level, from Adaptation to Maladaptation

edited by Gloria Dalla Costa and Laura Cacciaguerra

submission deadline 20 Feb 2026 | Viewed by 158 | Submission Open

Keywords: multiple sclerosis; neuroplasticity; remyelination; synaptic adaptations

(This special issue belongs to the Section Molecular Neurobiology)

Bioactive Lipid Metabolites in Age-Related Comorbidities: From Mechanisms to Therapeutics

edited by

Sadanand Fulzele

submission deadline 20 Feb 2026 | Viewed by 149 | Submission Open

Keywords: lipid metabolites; aging; sarcopenia; osteoporosis; osteoarthritis

(This special issue belongs to the Section Biochemistry)

Transcriptional Regulation and Its Misregulation in Human Diseases: Recent Insights

edited by

Amelia Casamassimi

and

Monica Rienzo

submission deadline 20 Feb 2026 | Viewed by 146 | Submission Open

Keywords: transcription machinery; transcription (co)factors; chromatin regulators; splicing regulators; noncoding RNAs; transcription misregulation; genetic alterations; human diseases; transcriptome profiling; bioinformatics analysis

(This special issue belongs to the Section Molecular Biology)

The Impact of the Immune System on the Tumor Microenvironment: Relevance to Glioma Development

edited by Gabriela Verónica Salamone

submission deadline 20 Feb 2026 | Viewed by 139 | Submission Open

Keywords: gliomas tumor microenvironment immune

(This special issue belongs to the Section Molecular Oncology)

Recent Research in Nanoelectrochemistry

edited by

Ioan Baldea

submission deadline 20 Feb 2026 | Viewed by 137 | Submission Open

Keywords: nanoelectrochemistry; single-entity electrochemistry; nanoscale imaging; molecular electronics devices; nanostructured electrodes; electrochemical sensors; energy storage; catalysis; biomedical applications

(This special issue belongs to the Section Materials Science)

Advancements in the Electrochemical Detection of Biomolecules: From Sensing to Environmental Applications

edited by

Habibulla Imran

submission deadline 20 Feb 2026 | Viewed by 135 | Submission Open

Keywords: biomolecules; nanomaterials; biorecognition; biomolecular detection; electrochemical

(This special issue belongs to the Section Molecular Biophysics)

Molecular Progress in Male Reproduction

edited by

Ahmet Ayaz

submission deadline 20 Feb 2026 | Viewed by 126 | Submission Open

Keywords: male infertility; spermatogenesis; epigenetics; sperm function; testicular molecular biology; bioinformatics; reproductive genomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Fungal Genetics and Functional Genomics Research

edited by

Yuqi Qin

and

Jian Zhao

submission deadline 20 Feb 2026 | Viewed by 110 | Submission Open

Keywords: enzymes; fungal genetics; fungi; gene editing; regulation; secondary metabolites; synthetic biology; transcription

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Advances in Gestational Diabetes Mellitus: 2nd Edition

edited by Natasha Singh

submission deadline 20 Feb 2026 | Viewed by 107 | Submission Open

Keywords: metabolome; placental insulin signaling; DNA methylation; mitochondrial oxidation; MTOR; amino acids lipidomics; proteomics; gluconeogenesis; GDM

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Abiotic Stress in Plants, 2nd Edition

edited by

Xiujun Zhang

submission deadline 20 Feb 2026 | Viewed by 104 | Submission Open

Keywords: abiotic stress; ROS; redox; antioxidants; phytohormones; ethylene; plant stress eco-physiology

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Biology of the Thyroid Cancer and Thyroid Dysfunctions: 2nd Edition

edited by Vija Lavinia

submission deadline 20 Feb 2026 | Viewed by 102 | Submission Open

Keywords: animal models; apoptosis; autophagy; cancer biomarker; cancer epidemiology; cancer prevention; cancer screening; cholesterol metabolism; clinical trial; DNA repair; epigenomics; genome instability; genomic database; genomics; invasion; metabolomics; metastasis; methylation; microarray; microRNA; molecular diagnostics; molecular tumor pathology; next-generation sequencing; noncoding RNA; omics; personalized medicine; prognosis; proteomics; radionuclide therapy; signaling pathway; SNP genotyping; targeted therapy; theranostics; thyroid cancer; hyperthyroidism; therapeutic targets; translational cancer research; treatment response; tumor microenvironment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biophysical Studies of Protein Structure-Function Relationships

edited by

Almerinda Di Venere

Giampiero Mei

and Velia Minicozzi

submission deadline 20 Feb 2026 | Viewed by 85 | Submission Open

Keywords: protein structure; molecular dynamics; computational modeling; drug discovery

(This special issue belongs to the Section Molecular Biophysics)

Molecular Progress of Cardiovascular and Metabolic Disease

edited by

Ilenia Calcaterra

submission deadline 20 Feb 2026 | Viewed by 81 | Submission Open

Keywords: cardiometabolic continuum; endothelial dysfunction; heart failure; metabolic complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Decoding Protein Structure and Protein Dynamics in Cancer

edited by

Umesh Kalathiya

and

Monikaben Padariya

submission deadline 20 Feb 2026 | Viewed by 80 | Submission Open

Keywords: protein structures; oncogenes; post-translational modifications (PTMs); cancer; proteomics; computational biology; structural biology; molecular modeling; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Molecular Pathogenesis and Treatment Approaches of Hematological Malignancies

edited by

Yosuke Minami

submission deadline 20 Feb 2026 | Viewed by 77 | Submission Open

Keywords: leukemia; lymphoma; minimal residual disease (MRD); cancer genomic profiling (CGP); molecular targeted therapy

(This special issue belongs to the Section Molecular Oncology)

Advances in Genetic and Epigenetic Research in Skin Diseases

edited by

Nikolai Pace

submission deadline 20 Feb 2026 | Viewed by 56 | Submission Open

Keywords: skin diseases; genodermatoses; psoriasis; atopic dermatitis; hidradenitis; suppurativa; epigenetic regulation; genome-wide association studies (GWAS); next-generation sequencing; translational dermatogenomics; Mendelian randomization; rare disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of the Mitochondria in Human Health and Diseases

edited by

María Isabel Hernández-Alvarez

submission deadline 25 Feb 2026 | 2 articles | Viewed by 13079 | Submission Open

Keywords: mitochondria; mitochondria contact sites; metabolism; lipids; metabolites

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Cell Proliferation, Senescence and Apoptosis

edited by

Chuanxi Cai

submission deadline 25 Feb 2026 | 3 articles | Viewed by 7454 | Submission Open

Keywords: biological molecules; cell proliferation; senescence; apoptosis; human diseases

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Human Retrovirus Infection: 2nd Edition

edited by

Yosuke Maeda

Toshio Hattori

and Kotaro Shirakawa

submission deadline 25 Feb 2026 | 3 articles | Viewed by 7429 | Submission Open

Keywords: retrovirus; ATL; HIV-1; AIDS

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research on Skin Inflammation

edited by

Nabiha Yusuf

submission deadline 25 Feb 2026 | 4 articles | Viewed by 7294 | Submission Open

Keywords: skin inflammation; molecular diagnosis; dermatitis; molecular pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 1851-1900 on page 38 of 70.

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