Molecular Mechanisms and Therapeutic Targets in Systemic Vasculitis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 March 2026
Special Issue Editor
Interests: systemic lupus erythematosus; autoimmune disease; autoinflammatory disease; Castleman’s disease; vasculitis, IgG4RD
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Systemic vasculitides represent a heterogeneous group of inflammatory disorders characterized by immune-mediated injury of blood vessels leading to tissue ischemia and organ dysfunction. Recent advances in molecular and cellular research have revealed new insights into the interplay between innate and adaptive immunity, endothelial activation, and effector pathways driving vascular inflammation and damage. Among these, complement activation has emerged as a crucial link between immune complex formation, neutrophil activation, and endothelial injury, contributing to both acute inflammation and chronic vascular remodeling.
This Special Issue aims to gather high-quality original research articles and comprehensive reviews focused on the molecular and immunopathogenic mechanisms underlying systemic vasculitis, including ANCA-associated vasculitides (GPA, MPA, and EGPA), immune complex–mediated and large-vessel vasculitis, as well as other autoinflammatory or clonal forms of vascular inflammation. Topics of interest include genetic susceptibility, cytokine and signaling networks, complement dysregulation, eosinophil-driven inflammation, endothelial dysfunction, biomarkers, and novel therapeutic targets. By integrating translational and clinical perspectives, this Special Issue aims to highlight current challenges and future directions in understanding and managing vasculitis at the molecular level.
Dr. Andrés González-García
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- nitrogen fixation genes
- vasculitis
- ANCA-associated vasculitis
- EGPA
- complement activation
- molecular immunopathogenesis
- endothelial dysfunction
- cytokine signaling
- biomarkers
- therapeutic targets
- autoimmunity
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
