MicroRNAs in Physiology and Pathophysiology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 55
Special Issue Editor
Special Issue Information
Dear Colleagues,
For more than twenty years, views on the biological roles of non-coding RNAs (ncRNAs) have been radically changing.
MicroRNAs (miRNAs) are well-known members of the ncRNA family that includes miRNAs, snRNAs, snoRNAs, scaRNAs, Y-RNAs, and piwiRNAs. MiRNAs are small, single-stranded RNAs about 22 nucleotides in length that are transcribed from our genome without the capacity to encode proteins. These ncRNAs are critical regulators of gene expression that affect a wide range of physiological processes necessary to maintain cellular homeostasis. On the other hand, the aberrant expression of miRNAs leads to various pathological conditions, particularly neoplastic disease. Binding of miRNAs to tumor suppressor and oncogene mRNAs is associated with cancer initiation, promotion, progression, and metastasis. Since the discovery of circulating miRNAs, the significance of these molecular players has increased, particularly as potential non-invasive biomarkers of different diseases. Importantly, it is known that miRNAs are promising markers also for prediction, disease monitoring, and therapy response in various human disease states. Currently, one of the main goals of miRNA research is to translate this theoretical knowledge into clinical practice.
This Special Issue is focused on recent advances in the involvement of miRNAs in physiological and pathological processes leading to different diseases. Discoveries of new molecular targets of miRNAs, miRNA-based diagnostic methods, and therapies are of special interest. Original research articles and reviews are welcome. We look forward to receiving your contributions.
Dr. Małgorzata Guz
Guest Editor
Manuscript Submission Information
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Keywords
- miRNA
- cell physiology
- metabolism
- cancer
- biomarkers
- disease
- molecular mechanisms
- diagnosis
- therapy
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