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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Co-Infections in Parasitic Diseases: Molecular Mechanisms, Diagnostic Challenges, and Therapeutic Strategies
edited by and Paula Gabriela Ragone
submission deadline 30 Oct 2026 | Viewed by 165 | Submission Open
Keywords: parasites; protozoan; co-infections; disease outcome; immune modulation; metagenomic analysis; diagnostic methods; treatment strategies; drug resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Plant Virus Life Cycle, Molecular Diagnosis, Virus–Host Interactions and Molecular Farming submission deadline 30 Oct 2026 | Viewed by 156 | Submission Open
Keywords: plant viruses; molecular biology; replication; assembly; transmission; trafficking; virus–host interactions; plant defense responses; molecular diagnostics; RNA silencing structure
(This special issue belongs to the Section Molecular Plant Sciences)
Improving Antimicrobial Activity of Biopolymer-Based Films: Mechanisms, Functionalization Strategies, and Applications
edited by
submission deadline 30 Oct 2026 | Viewed by 153 | Submission Open
Keywords: biopolymer-based films; antimicrobial activity; functionalization strategies; bioactive compounds; nanoparticles; deep eutectic solvents; plasticizers; structure–property relationships; biodegradable materials; coatings and membranes
(This special issue belongs to the Section Materials Science)
Global Impact of Malignant Pleural Mesothelioma: Current Knowledge, Emerging Therapies and Future Perspectives
edited by Saé Muñiz-Hernández
submission deadline 30 Oct 2026 | Viewed by 131 | Submission Open
Keywords: pattern identification through AI; gene-driven mesothelioma; biomarkers; organoid models; genetic and epigenetic analysis
(This special issue belongs to the Section Molecular Oncology)
In Silico Methods of Assessing the Therapeutic Potential of Natural Substances submission deadline 31 Oct 2026 | 6 articles | Viewed by 19813 | Submission Open
Keywords: in silico screening; natural products; molecular docking; computational drug discovery; QSAR modeling; molecular dynamics simulations; natural compounds; drug-target interactions; virtual screening; structure-activity relationships; computational chemistry; cheminformatics; ADMET prediction; bioinformatics; phytochemicals; machine learning in drug discovery; computer-aided drug design; pharmacophore modeling; natural therapeutics; computational pharmacology
(This special issue belongs to the Section Molecular Informatics)
Molecular Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease
edited by Rifaat Safadi and Johnny Amer
submission deadline 31 Oct 2026 | 8 articles | Viewed by 15099 | Submission Open
Keywords: MASLD (metabolic dysfunction-associated steatotic liver disease); lipotoxicity; inflammation; mitochondrial dysfunction; gut–liver axis; liver–spleen axis; fibrosis biomarkers; translational hepatology; precision liver medicine; insulin resistance; molecular therapeutics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Endocrinology of Pregnancy submission deadline 31 Oct 2026 | 3 articles | Viewed by 14257 | Submission Open
Keywords: pregnancy; endocrine system; fetal development; maternal health; metabolism
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Genomics of Human Disease
edited by
submission deadline 31 Oct 2026 | 9 articles | Viewed by 12084 | Submission Open
Keywords: genome-wide association study (GWAS); next-generation sequencing (NGS); multi-omics analysis; epidemiology data analysis; precision medicine approaches; disease prediction analysis
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Protein Structure-Function and Drug Discovery
edited by Francesc Xavier Avilés and F. Xavier Gomis-Rüth
submission deadline 31 Oct 2026 | 6 articles | Viewed by 11616 | Submission Open
Keywords: protein structure; protein function; protein drug target; inhibition; protein structure-function; protein drug discovery; protein inhibition; protein activation; protein regulation; protein structure-function and evolution; protein structure-function engineering and design; protein structure-function and drug discovery
(This special issue belongs to the Section Macromolecules)
Natural Medicines and Functional Foods for Human Health
edited by Qiong Wang
submission deadline 31 Oct 2026 | 3 articles | Viewed by 11445 | Submission Open
Keywords: functional food; natural medicine; traditional Chinese medicine; memory; depression; dementia; Alzheimer’s disease; Parkinson’s disease; space medicine; sleeplessness; anti-inflammation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Role of Autoimmunity in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder
edited by Yang Mao-Draayer
submission deadline 31 Oct 2026 | 1 articles | Viewed by 10982 | Submission Open
Keywords: multiple sclerosis (MS); neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); immunomodulatory; neuroprotection; neuroregeneration; biomarker; imaging
(This special issue belongs to the Section Molecular Neurobiology)
Anti-Inflammatory and Anti-Oxidant Effects of Extracts from Plants submission deadline 31 Oct 2026 | 5 articles | Viewed by 10735 | Submission Open
Keywords: oxidative stress; inflammation; herbal extracts
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Research Advances in Antibiotic Resistance submission deadline 31 Oct 2026 | 5 articles | Viewed by 9592 | Submission Open
Keywords: antibiotic resistance; resistant pathogenic microorganisms; One Health; prevalence of antibiotic-resistant microorganisms; multidrug resistance; antibiotic resistance levels; alternative anti-infectious strategies and compounds; antibiotic-resistant genes; mechanisms of antimicrobial resistance
(This special issue belongs to the Section Molecular Microbiology)
Molecular Insights into Anxiety and Depression: Pathomechanisms and Therapeutic Strategies submission deadline 31 Oct 2026 | 2 articles | Viewed by 9367 | Submission Open
Keywords: anxiety; depression; anxiolytics; antidepressants; animal models
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights and Novel Therapeutics in Chronic Kidney Disease
edited by
submission deadline 31 Oct 2026 | 6 articles | Viewed by 8879 | Submission Open
Keywords: chronic kidney disease (CKD); molecular mechanisms; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Endothelial Cell Injury and Repair submission deadline 31 Oct 2026 | 5 articles | Viewed by 8801 | Submission Open
Keywords: endothelial injury; endothelial repair; endotheliopathies; endothelial dysfunction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapeutic Potential of Natural Compounds
edited by and Adrianna Sławińska-Brych
submission deadline 31 Oct 2026 | 6 articles | Viewed by 7301 | Submission Open
Keywords: natural products; biological activity; bioactive compounds; mechanistic study; mechanism of action; drug discovery; pharmacological activity; synergism
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Ferroptosis, ROS and Cell Death Cytomodulator Compounds
edited by Alireza Valanezhad
submission deadline 31 Oct 2026 | 3 articles | Viewed by 7213 | Submission Open
Keywords: cell death; ferroptosis; ROS; GPX4; lipid peroxidation; inhibitors; inducers; cytomodulator compounds; cancer; disease; bone formation
(This special issue belongs to the Section Biochemistry)
The Molecular Network, Key Biomarkers, and Therapeutic Targets in Colorectal Cancer submission deadline 31 Oct 2026 | 3 articles | Viewed by 7146 | Submission Open
Keywords: inflammation; metabolism; tumor-associated macrophages; tumor microenvironment; early-onset colorectal cancer; colorectal neoplasms; obesity; immunotherapy; epigenetics; cytokines; microbiome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Transcendental World of Plant Toxic Compounds
edited by
submission deadline 31 Oct 2026 | 3 articles | Viewed by 7133 | Submission Open
Keywords: alcaloids; biotic stress; defence; phenols; phytotoxins; secondary metabolism; terpenes
(This special issue belongs to the Section Molecular Plant Sciences)
New Insights into Molecular Mechanisms of Chronic Kidney Disease submission deadline 31 Oct 2026 | 2 articles | Viewed by 7096 | Submission Open
Keywords: chronic kidney disease; molecular mechanism; signaling pathways; endothelial dysfunction; inflammation; genetic variants; epigenetics; oxidative stress
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Genomic Aspects of Viral Pathogens
edited by
submission deadline 31 Oct 2026 | 4 articles | Viewed by 6329 | Submission Open
Keywords: viral pathogens; genetic and molecular mechanisms; viral infection; viral replication; host interaction
(This special issue belongs to the Section Molecular Microbiology)
Design of Bioactive Agents and Interaction with Biological Systems
edited by
submission deadline 31 Oct 2026 | 3 articles | Viewed by 6028 | Submission Open
Keywords: natural and synthetic compounds; bioactive agents and materials; design and discovery; targeting; intermolecular interactions; omics; structure and dynamics of biomolecules; theoretical analysis of biomolecular structures; analytical and biophysical methods; molecular biology/biochemistry; chemical biology/biological chemistry
(This special issue belongs to the Section Molecular Biology)
Molecular Pathways to Infertility
edited by
submission deadline 31 Oct 2026 | 5 articles | Viewed by 5976 | Submission Open
Keywords: infertility; molecules; meiotic arrest; premature ovarian insufficiency; sperm function; progesterone resistance; mitochondrial dysfunction; epigenetic dysregulation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bone and Cartilage Injury and Repair: Molecular Aspects
edited by Silvia María Díaz-Prado
submission deadline 31 Oct 2026 | 2 articles | Viewed by 5809 | Submission Open
Keywords: bone and cartilage repair; regenerative medicine; inflammation and immune response; stem cell therapy; extracellular matrix remodeling; biomaterials; drug delivery systems; therapeutic targets; biomarkers
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Reproduction and Fertility of Aquatic Animals: 3rd Edition
edited by and Hongtuo Fu
submission deadline 31 Oct 2026 | 5 articles | Viewed by 5379 | Submission Open
Keywords: reproduction; aquatic animals; sex determination; gonadal development; steroid hormones; sex-related genes; monosex culture
(This special issue belongs to the Section Molecular Biology)
Biosensors: Emerging Technologies and Real-Time Monitoring
edited by Velmurugan Thavasi
submission deadline 31 Oct 2026 | 3 articles | Viewed by 5206 | Submission Open
Keywords: biosensors; real-time monitoring; wearable sensors; electrochemical detection; optical biosensors; point-of-care (POC) diagnostics; biomarker identification and analysis; wireless technologies
(This special issue belongs to the Section Biochemistry)
Advancements in Pathogen Detection, Microdevice Technologies and AI-Driven Analysis
edited by
submission deadline 31 Oct 2026 | 4 articles | Viewed by 4919 | Submission Open
Keywords: pathogen detection; microfluidic; microdevice; AI analysis; virus; bacteria; point-of-care testing; infectious disease; nanotechnology
(This special issue belongs to the Section Molecular Biology)
Metabolic Dynamics and Immune Surveillance in the Tumor Microenvironment
edited by
submission deadline 31 Oct 2026 | 5 articles | Viewed by 4656 | Submission Open
Keywords: cancer; TME; metabolism; immune cells; signaling pathway; therapy
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advances in Vaccine Immunology
edited by
submission deadline 31 Oct 2026 | 3 articles | Viewed by 4548 | Submission Open
Keywords: vaccine-induced immunity; systems vaccinology; single-cell immune profiling; multiomics; correlates of Protection; innate immunity; adjuvants; artificial Intelligence; immunomodulation; tissue-specific immune activation
(This special issue belongs to the Section Molecular Immunology)
Proteases and Their Inhibitors
edited by
submission deadline 31 Oct 2026 | 3 articles | Viewed by 4451 | Submission Open
Keywords: protease; serine proteases; thiol proteases; acid proteases; metalloproteases; protease inhibitor; SERPINs
(This special issue belongs to the Section Biochemistry)
Computational Studies of Natural Products
edited by
submission deadline 31 Oct 2026 | 4 articles | Viewed by 3909 | Submission Open
Keywords: computational chemistry; natural products; structural elucidation; Nuclear Magnetic Resonance (NMR); Density Functional Theory (DFT)
(This special issue belongs to the Section Molecular Informatics)
Advances in Peripheral Nerve Regeneration—2nd Edition
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 3291 | Submission Open
Keywords: peripheral nerve regeneration; schwann cells; axonal regrowth; nerve regrowth
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Laboratory Animal Research for Precision Medicine in Cardiovascular Diseases
edited by Conrado Calvo
submission deadline 31 Oct 2026 | 1 articles | Viewed by 3167 | Submission Open
Keywords: cardiovascular disease; experimental models and research; arrhythmias and cardiac electrophysiology; molecular science and imaging techniques; myocardial ischemia and heart failure; cardiac fibrillation and sudden cardiac death; circulation and blood vessels; diabetes and metabolic disorders; experimental datasets for precision medicine; data-driven in silico approaches
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Role of the Gut-Islet Axis in and Beyond Metabolic Diseases
edited by Simona Georgiana Popa
submission deadline 31 Oct 2026 | 1 articles | Viewed by 3128 | Submission Open
Keywords: entero-insular axis; adipocytokines; precision therapy; insulin resistance; type 2 diabetes; neuroprotection; aging
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Hormonal and Metabolic Markers in Health and Disease submission deadline 31 Oct 2026 | 2 articles | Viewed by 3122 | Submission Open
Keywords: hormonal biomarkers; molecular mechanism of endocrine disorders; steroidogenesis; hormonal dysregulation; endocrine disruptors; metabolomics; metabolic regulation
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Evolutionary Genomics in Plants: From Single Gene to Genome
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 3087 | Submission Open
Keywords: evolutionary genomics; plant adaptation; genome evolution; crop improvement; bioinformatics; polyploidy
(This special issue belongs to the Section Molecular Plant Sciences)
Novel Mechanisms of Receptor Activation
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2901 | Submission Open
Keywords: G protein-coupled receptors; nuclear (steroid) hormone receptors; catalytic receptors; receptor structural motifs important for activation; receptor pharmacophores; structure–function correlates; cellular functions; integrated physiology; compartmentalized GPCRs; receptor pharmacology; aryl hydrocarbon receptor (AHR); “orphan” GPCRs
(This special issue belongs to the Section Biochemistry)
Molecular Insights into Liver Disease: Pathogenesis, Progression, and Therapeutic Strategies
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 2786 | Submission Open
Keywords: liver disease; molecular pathogenesis; therapeutic strategies; liver fibrosis; hepatocellular carcinoma; MASLD and MetALD; molecular biomarkers; tailored medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Emerging Viral Epidemics
edited by Nikolaos Siafakas
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2770 | Submission Open
Keywords: emerging viruses; diagnostic virology; viral epidemiology; viral evolution; zoonotic infections; public health; surveillance
(This special issue belongs to the Section Molecular Microbiology)
Enzymes and Enzyme Inhibitors—Applications in Medicine and Diagnosis, 3rd Edition
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2629 | Submission Open
Keywords: enzyme; enzyme inhibitor; drug target; enzyme deficiency; enzyme overexpression; biomarker; drugs; diagnosis; therapy
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Genetic Research in Skin Diseases submission deadline 31 Oct 2026 | 1 articles | Viewed by 2505 | Submission Open
Keywords: inflammatory skin diseases; genome-wide association studies (GWAS); epigenetic modifications; multi-omic integration; precision dermatology
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular and Cellular Research on Taste Receptors
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2462 | Submission Open
Keywords: taste receptors; taste signaling; gustatory system; molecular signaling; cellular mechanisms; health and disease; functional roles; neurobiology of taste; cancer biology and metastasis; translational research
(This special issue belongs to the Section Molecular Biology)
Interplay Between Blood Cells and Cytokines submission deadline 31 Oct 2026 | 1 articles | Viewed by 2453 | Submission Open
Keywords: blood cells; communication; cytokine; erythrocyte; immunology; inflammation; interplay; leucocyte; platelet; network
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Tumor Markers and Tumor Microenvironment
edited by Tamás Micsik
submission deadline 31 Oct 2026 | 3 articles | Viewed by 2420 | Submission Open
Keywords: tumor markers; tumor environment; molecular and genetics; omics; artificial intelligence; digital pathology; computational pathology; individualized therapy; prognostication
(This special issue belongs to the Section Molecular Oncology)
Adipose Tissue as a Central Driver of Obesity-Related Complications submission deadline 31 Oct 2026 | 3 articles | Viewed by 2407 | Submission Open
Keywords: obesity; adipose tissue; adipokine; cardiometabolic disease; metabolic complications
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Next-Generation Antimicrobials and Anticancer Agents: From Natural to Synthetic Compounds
edited by and Roxana Popescu
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2363 | Submission Open
Keywords: bioactive molecules; natural products; synthetic compounds; molecular design; antimicrobial agents; anticancer agents; drug-resistant infections; drug discovery
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms and Therapeutic Targets in Inflammation and Cancer Immunity
edited by
submission deadline 31 Oct 2026 | 2 articles | Viewed by 2279 | Submission Open
Keywords: immune regulation; inflammation; cancer immunity; immunotherapy; cytokine signaling; therapeutic targets; immune evasion; antibody-based therapy; histamine; drug repositioning
(This special issue belongs to the Section Molecular Immunology)
Genome Editing in Autologous Stem Cells: From Bench to Bedside
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 2269 | Submission Open
Keywords: genome editing; gene therapy; autologous transplant; preclinical studies; process development; scalability; quality control; manufacturing; regulatory compliance; IND-enabling studies
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Mechanisms and Pathophysiology of Sepsis (2nd Edition)
edited by
submission deadline 31 Oct 2026 | 1 articles | Viewed by 2260 | Submission Open
Keywords: animal models; therapeutic concepts; biomarkers; sepsis; immune suppression; epigenetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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