Adipose Tissue as a Central Driver of Obesity-Related Complications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 2475
Editors
Interests: obesity; diabetes mellitus; MAFLD; renal failure; metabolic syndrome; prediabetes; atherosclerosis; metabolic inflammation; insulin resistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Obesity has emerged as a defining feature of the global pandemic of non-communicable chronic diseases, with a steadily increasing prevalence despite sustained public health efforts. Beyond its epidemiological scale, obesity is now recognized as a disorder of adipose tissue biology, characterized by adipocyte hypertrophy, impaired lipid buffering, and a shift toward a pro-inflammatory secretory phenotype. Dysfunctional adipose tissue drives a network of molecular disturbances—including dysregulated adipokine signaling, chronic low-grade inflammation, mitochondrial dysfunction, and oxidative stress—that collectively promote insulin resistance, type 2 diabetes mellitus, and cardiovascular disease.
This Special Issue aims to provide an integrative perspective on the molecular and pathophysiological mechanisms underlying adipose tissue dysfunction that initiates and sustains obesity-related tissue injury. We invite original research and reviews addressing adipokine-mediated crosstalk; immune cell infiltration and inflammatory remodeling; pathways linking adipocyte dysfunction to insulin resistance and β-cell failure; and cardiovascular remodeling in metabolic dysregulation. Additional topics include ectopic lipid deposition, organ-specific lipotoxicity, and translational links to clinical cardiometabolic phenotypes.
Emphasis will be placed on pharmacological interventions—including GLP-1 receptor agonists and SGLT2 inhibitors—and emerging therapies targeting adipose tissue biology. We warmly invite researchers across disciplines to contribute their work and perspectives, and to join us in advancing the understanding of adipose tissue dysfunction in cardiometabolic disease.
Dr. Anca Pantea Stoian
Dr. Teodor Salmen
Guest Editors
Manuscript Submission Information
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Keywords
- obesity
- adipose tissue
- adipokine
- cardiometabolic disease
- metabolic complications
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