Molecular Pathways to Infertility
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 2110
Special Issue Editor
Special Issue Information
Dear Colleagues,
Infertility is a complex condition affecting 5–15% of reproductive-age couples. Multifactorial etiologies at the molecular, genetic, hormonal, and cellular levels are involved in the inability of couples to achieve a pregnancy. Disruptions in key molecular pathways can compromise gametogenesis, fertilization, embryo development, and implantation.
The scope of this Special Issue is to describe the molecular pathways leading to infertility. These pathways concern hormonal regulation, genetic and epigenetic alterations, oxidative stress, immunity and inflammation, apoptosis, mitochondrial dysfunction, and defects in DNA repair mechanisms.
A comprehensive understanding of these pathways is essential for identifying the underlying causes of idiopathic infertility. It will improve the diagnostic precision and the development of targeted therapeutic interventions.
Dr. Apostolos Kaponis
Guest Editor
Manuscript Submission Information
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Keywords
- infertility
- molecules
- meiotic arrest
- premature ovarian insufficiency
- sperm function
- progesterone resistance
- mitochondrial dysfunction
- epigenetic dysregulation
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