Genome Editing in Autologous Stem Cells: From Bench to Bedside
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 30 October 2025 | Viewed by 29
Special Issue Editor
Special Issue Information
Dear Colleagues,
Precise genome editing technologies have revolutionized the field of regenerative medicine, enabling autologous stem cell transplantation as a potential therapeutic option for multiple diseases. These emerging therapies offer a promising alternative to allogeneic transplantation, eliminating the need for donors and minimizing immune complications.
We are pleased to invite you to contribute to our Special Issue, “Genome Editing in Autologous Stem Cells: From Bench to Bedside”. This Special Issue aims to highlight recent advances and ongoing challenges in translating the genome editing of autologous stem cells from the research lab to clinical application.
We welcome original research articles, reviews, commentaries, and short communications. Relevant research areas include (but are not limited to) the following:
- Preclinical studies: genome editing tools, delivery systems, and new strategies to improve editing efficiency in stem cells; preclinical models and proof-of-concept studies for disease correction;
- Clinical product development: process development, scalability, quality control, chemistry, manufacturing, and controls (CMC), and regulatory pathways;
- Safety: safety assessments, off-target analyses, and regulatory requirements;
- Ethics: ethical, economic, and accessibility issues with autologous genome-edited products.
We look forward to receiving your contributions.
Dr. Edina Poletto
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- genome editing
- gene therapy
- autologous transplant
- preclinical studies
- process development
- scalability
- quality control
- manufacturing
- regulatory compliance
- IND-enabling studies
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