Advances in Vaccine Immunology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 1
Special Issue Editor
Special Issue Information
Dear Colleagues,
Vaccines aim to direct the immune system to protect against pathogens; however, we do not fully understand the mechanisms behind an effective response. Traditional assessment of vaccine-induced immunity has focused on measuring antibody titers, neutralization, or cellular function. These indices fail to capture the full complexity of the immune response. New platforms such as mRNA technologies, nanoparticle delivery systems, and novel adjuvants offer opportunities to modulate immune pathways at a level of precision previously not attainable. At the same time, advances in immunologic profiling, including single-cell sequencing, receptor repertoire analysis, and systems serology, allow for a detailed characterization of vaccine responses at a higher resolution.
This Special Issue will highlight recent advances in targeting vaccines to engage specific immune compartments and new immunologic technologies to understand these responses. We invite original research, reviews, and perspectives that explore strategies for engaging specific components of innate and adaptive immunity, as well as methods for quantifying, modeling, or predicting vaccine efficacy. We encourage studies that apply artificial intelligence and machine learning to integrate multi-omics data. Relevant topics include antigen design and structure, epitope mapping, B- and T-cell dynamics, immune memory, adjuvant function, and integrative systems biology approaches. Studies in human cohorts and preclinical models are welcome. Contributions should advance our understanding of how vaccines shape the immune system and how we can more accurately define correlates of protection.
Dr. Michael Eller
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- vaccine-induced immunity
- systems vaccinology
- single-cell immune profiling
- multiomics
- correlates of Protection
- innate immunity
- adjuvants
- artificial Intelligence
- immunomodulation
- tissue-specific immune activation
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