Molecular Insights and Novel Therapeutics in Chronic Kidney Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 9
Special Issue Editor
Interests: biochemistry; biomarkers; hypertension; cardiovascular disease; kidney disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic kidney disease (CKD) remains a major global health challenge, characterized by progressive loss of renal function, high morbidity, and limited treatment options beyond supportive care and renal replacement therapy. Despite advances in clinical management, the molecular mechanisms underlying CKD initiation and progression are still incompletely understood, hampering the development of targeted and personalized therapies. This Special Issue, “Molecular Insights and Novel Therapeutics in Chronic Kidney Disease”, aims to bring together cutting-edge research and reviews that explore the molecular basis of CKD, identify novel biomarkers, and highlight innovative therapeutic approaches. We particularly welcome contributions that leverage high-throughput omics technologies (transcriptomics, genomics, proteomics, metabolomics, and epigenomics) to unravel disease mechanisms, discover biomarkers for risk prediction, and guide precision medicine strategies. Topics of interest include but are not limited to molecular pathways driving inflammation, fibrosis, and immune dysregulation in CKD; omics-based discovery of biomarkers for early diagnosis, prognosis, and therapeutic monitoring; integration of multi-omics datasets with bioinformatics and machine learning to define CKD subtypes; translational studies linking molecular insights to clinical outcomes; emerging therapeutic strategies, including novel drugs, biologics, gene- and cell-based therapies, and repurposed agents targeting key molecular pathways; experimental models that provide mechanistic insight and support therapeutic innovation. By collecting state-of-the-art findings at the interface of molecular nephrology, systems biology, and therapeutic development, this Special Issue seeks to advance our understanding of CKD and pave the way toward precision nephrology.
Prof. Dr. Marijn Speeckaert
Guest Editor
Manuscript Submission Information
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Keywords
- chronic kidney disease (CKD)
- molecular mechanisms
- precision medicine
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