Advances in Peripheral Nerve Regeneration—2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 1937
Special Issue Editor
Interests: glia; protease activated receptors (PARs); environmental toxins; autophagy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Unlike the central nervous system, the peripheral nervous system is able to regenerate promptly following an injury. Its regenerative capacity is largely related to the ability of Schwann cells to dedifferentiate and drive axonal regrowth. Peripheral nerve regeneration is, however, limited in space and time. Therefore, there is a compelling need to develop strategies to promote peripheral nerve regeneration, especially in elderly individuals and those with other concomitant diseases (e.g., diabetes). This Special Issue aims to gather contributions regarding various aspects underlying axonal regrowth following tissue injury. Articles describing the complex interplay between peripheral nerves and cancer will also be considered. ln fact, cancer can be viewed as an injury in that it damages the normal cytoarchitecture of a tissue, leading to the activation of nerve-regenerative mechanisms that can then promote tumor growth and dissemination. In this context, a large body of research suggests that activated Schwann cells appear to play a key role in creating a pro-tumor microenvironment. Their connection to cancer-induced innervation is not well described, and they should instead be considered as pathological activators of axonal growth and attraction.
The Special Issue is a continuation of “Advances in Peripheral Nerve Regeneration” (https://www.mdpi.com/journal/ijms/special_issues/NWI8F3N9W3). We invite investigators to contribute original research articles and reviews that aim to describe factors that favor or limit nerve regrowth after an injury. The following is a non-exhaustive list of topics that we aim to cover in this Special Issue:
- Schwann cell biology;
- Biomaterials and nerve scaffolds;
- Neurotrophic and gliotrophic factors;
- Inflammatory cytokines;
- Nerve/tumor crosstalk;
- Schwann cells and the tumor microenvironment.
Dr. Cinzia Fabrizi
Guest Editor
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Keywords
- peripheral nerve regeneration
- schwann cells
- axonal regrowth
- nerve regrowth
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