Ferroptosis, ROS and Cell Death Cytomodulator Compounds
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 23
Special Issue Editor
Special Issue Information
Dear Colleagues,
Aim: To discuss the potential of cytomodulator compounds in controlling the roles of ferroptosis and ROS in regulated cell death within disease and bone formation contexts.
Scope: Ferroptosis is a regulated form of cell death driven by iron-dependent lipid peroxidation and the accumulation of reactive oxygen species (ROS). Unlike apoptosis or necrosis, ferroptosis is characterized by overwhelming oxidative stress and damage to membrane lipids, ultimately compromising cell integrity. ROS, which are chemically reactive molecules derived from oxygen, play a central role in initiating and propagating ferroptosis by promoting lipid peroxidation and disrupting redox homeostasis.
To regulate ferroptosis and ROS-induced cell death, cytomodulator compounds have emerged as promising tools. These molecules can either induce or inhibit ferroptosis by modulating cellular antioxidant defenses, iron metabolism, and lipid peroxidation pathways. For instance, ferroptosis inhibitors like ferrostatin-1 and liproxstatin-1 function as radical-trapping agents, neutralizing ROS and preventing lipid peroxidation. Conversely, inducers such as erastin and RSL3 impair glutathione metabolism or inhibit GPX4, enhancing ROS accumulation and triggering ferroptotic death.
These cytomodulators are being explored as potential therapeutic inhibitors to protect healthy tissues from oxidative damage and as inducers to selectively kill cancer cells. Thus, targeting ROS and ferroptosis with cytomodulator compounds offers a powerful strategy to manipulate cell death pathways in various diseases.
Dr. Alireza Valanezhad
Guest Editor
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Keywords
- cell death
- ferroptosis
- ROS
- GPX4
- lipid peroxidation
- inhibitors
- inducers
- cytomodulator compounds
- cancer
- disease
- bone formation
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