Advances in Laboratory Animal Research for Precision Medicine in Cardiovascular Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 51
Special Issue Editor
Interests: electrophysiology; arrhythmia dynamics; cardiovascular disease; metabolic syndrome; laboratory animal models of disease; molecular imaging techniques; electrical and optical mapping; heart rate variability and autonomic control; artificial intelligence and big data in precision medicine; data-driven in-silico approaches; cardiovascular computational models and techniques; bioengineering; biophysics
Special Issue Information
Dear Colleagues,
Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, demanding relentless efforts to unravel its complex mechanisms and develop innovative diagnostic and therapeutic strategies. Laboratory animal research continues to be indispensable for advancing our understanding of cardiac and vascular pathophysiology, identifying key risk factors, and validating novel therapeutic targets. Relevant animal models of disease provide significant information on the pathophysiology of CVD, enabling us to explore procedures and analyze multiple variables under controlled conditions, which are otherwise difficult to test in clinical settings.
Furthermore, advances in laboratory animal research are pivotal for validating precision medicine strategies, enabling the development of tailored therapies and predictive models that account for individual variability in disease mechanisms and treatment responses. Moreover, the validation of novel molecular and imaging modalities and diagnostic techniques in preclinical models is essential to successfully translate research from laboratory settings to clinical application.
On behalf of the International Journal of Molecular Sciences (IJMS), this Special Issue aims to showcase cutting-edge research employing relevant animal models to bridge critical knowledge gaps in CVD. From elucidating the molecular and cellular underpinnings of disease to refining diagnostic tools and validating therapeutic interventions, animal studies remain at the forefront of translational cardiovascular research. Furthermore, insights gained from animal models contribute to developing sophisticated in silico models, enhancing predictive capabilities for disease progression and treatment response.
We would therefore like to invite experts to contribute original research articles or reviews focused on different aspects of experimental research applied in the study of cardiovascular disease. Topics of interest include (but are not limited to) the following: novel findings in the use of animal models to study the pathophysiological mechanisms underlying the manifestation of cardiovascular disease; innovative experimental and/or computational methodologies; data-driven in silico strategies; diagnostic techniques and medical–surgical treatments; and advances in laboratory animal research and future perspectives that push the boundaries of our understanding of cardiovascular disease and the application of precision medicine.
We look forward to receiving your contributions.
Sincerely,
Dr. Conrado Calvo
Guest Editor
Manuscript Submission Information
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Keywords
- cardiovascular disease
- experimental models and research
- arrhythmias and cardiac electrophysiology
- molecular science and imaging techniques
- myocardial ischemia and heart failure
- cardiac fibrillation and sudden cardiac death
- circulation and blood vessels
- diabetes and metabolic disorders
- experimental datasets for precision medicine
- data-driven in silico approaches
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