The Role of Autoimmunity in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 July 2025 | Viewed by 765
Special Issue Editor
Interests: multiple sclerosis (MS); neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); immunomodulatory; neuroprotection; neuroregeneration; biomarker; imaging
Special Issue Information
Dear Colleagues,
Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD), including myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), is one of the most exciting, emerging fields in neurology. Recent pathophysiological insights, derived from both animal models and clinical studies, paved the way for the regulatory approval of novel therapies, like oral compounds, small molecules, or monoclonal antibodies. Some of these compounds possibly act beyond their well-established immunomodulatory properties, for instance, by inducing direct neuroprotection or neuroregeneration. Of note, childhood MS, NMOSD, and MOGAD have been recognized as significant medical problems, and novel therapies are increasingly tested for this population. However, important, unmet medical needs remain, and the quest for even more sophisticated treatment strategies continues. For example, promising preclinical and clinical data exist regarding the modulation of costimulatory molecules and kinases in immune cells, B cell function, and the functional state of the blood–brain barrier. In addition, improved biomarkers beyond neurofilament light chain (Nfl) and imaging techniques, such as diffusion tensor imaging (DTI) or optical coherence tomography (OCT), have helped gain in vivo insights into the pathophysiological processes directly acting in patients.
The upcoming Special Issue on "The Role of Autoimmunity in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder" will cover all aspects of this most prevalent neuroimmunological disease. We invite authors to submit original articles or state-of-the-art reviews on MS pathophysiology, therapy, epidemiology, environmental factors, and imaging. All contributions will undergo a rapid, fair, and concise review process to minimize publication times. We look forward to receiving your valuable submissions.
Prof. Dr. Yang Mao-Draayer
Guest Editor
Manuscript Submission Information
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Keywords
- multiple sclerosis (MS)
- neuromyelitis optica spectrum disorder (NMOSD)
- myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD)
- immunomodulatory
- neuroprotection
- neuroregeneration
- biomarker
- imaging
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