The Molecular Network, Key Biomarkers, and Therapeutic Targets in Colorectal Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 July 2025 | Viewed by 70
Special Issue Editor
Interests: inflammation; metabolism; colorectal cancer; tumor-associated macrophages; intestinal macrophage; obesity, cytokines; necrotizing enterocolitis; preterm infant
Special Issue Information
Dear Colleagues,
Colorectal cancer (CRC) is the third most common cancer worldwide with significantly improved mortality among high-income countries due to national and regional screening programs. Paradoxically, in adults younger than 50 years of age, the incidence of CRC is dramatically increasing, with frequent diagnoses at an advanced tumor stage. While surgical resection is the primary therapy in CRC, patients with advanced-stage tumors only have limited therapeutic options, and new targeted therapies are urgently needed. The pathophysiology of CRC is multifactorial, with most cancers being non-hereditary. They result from a series of somatic mutations acquired over time due to environmental and lifestyle stressors, which are leading to genomic instability. Key biomarkers and novel molecular targets can potentially be identified in signaling pathways that are altered by these stressors. This is crucial to develop novel treatment mechanisms translating into clinical practice to decrease mortality and improve outcomes in advanced CRC, particularly among the young.
Dr. Katharina M. Robertson
Guest Editor
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Keywords
- inflammation
- metabolism
- tumor-associated macrophages
- tumor microenvironment
- early-onset colorectal cancer
- colorectal neoplasms
- obesity
- immunotherapy
- epigenetics
- cytokines
- microbiome
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