Enzymes and Enzyme Inhibitors—Applications in Medicine and Diagnosis, 3rd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 888
Special Issue Editor
Interests: biologically active heterocycles; thiazole; thiazolidinone; benzohiazole; thiadiazoles with antimicrobial activity; COX/LOX; PTP1b; HIV RT enzyme inhibitors; antiinflammatory; nootropics
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Special Issue Information
Dear Colleagues,
This Special Issue is the third edition of “Enzymes and Enzyme Inhibitors—Applications in Medicine and Diagnosis”.
https://www.mdpi.com/journal/ijms/special_issues/Enzyme_Inhibitors_ijms
https://www.mdpi.com/journal/ijms/special_issues/Enzyme_Inhibitors_ijms2
Our aim is to gather research and review articles on enzymes and enzyme inhibitors with applications in diagnosis and therapy across all areas of medical research.
As enzymes are involved in all biochemical processes, there are numerous pathological disorders related to the deficiency, malfunction, reduced/increased activity, or overexpression of enzymes. In addition, deficiencies in enzyme inhibitors are also responsible for several serious diseases. Therefore, the study of enzymes and their inhibitors is crucial for the elucidation of the pathophysiology of diseases and the exploration of therapeutic strategies, making this an important area of continuous research.
The role of enzymes in the regulation of all processes has turned them into important drug targets. Enzyme inhibitors constitute the second largest drug category, following receptor agonists and antagonists. Enzyme inhibitors are among the drugs used for the treatment of metabolic and degenerative diseases, including hypercholesterolemia, diabetes, and hypertension, as well as antimicrobial and antiviral therapy. The large number of isoenzymes in the human body necessitates the development of highly specific and effective inhibitors in order to achieve the targeted effect with fewer undesired side effects. This goal has led to the continuation of research into the development of novel and improved inhibitors, even for old enzyme targets, while the development of strains resistant to antimicrobial and antiviral therapy underlines the continuous need for novel inhibitors and novel targets.
In the field of diagnosis, enzymes are important biomolecules. The levels of enzymes and specific isoenzymes can be measured for the diagnosis and monitoring of many diseases. Although specific isoenzyme inhibitors enable the differential measurement of organ-specific isoenzymes in some cases, these inhibitors have not been found for most enzymes. On the other hand, the number of enzymes and related methods being used to make enzymatic assays for the measurement of other biomarkers, within classic methods, dry chemistry, and bioelectrode-based techniques, is increasing.
We call on you to contribute to this Special Issue by submitting research and review articles related to this topic.
Prof. Dr. Athina Geronikaki
Guest Editor
Manuscript Submission Information
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Keywords
- enzyme
- enzyme inhibitor
- drug target
- enzyme deficiency
- enzyme overexpression
- biomarker
- drugs
- diagnosis
- therapy
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