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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Research in Antioxidant Activity
edited by Demetrios Kouretas and
submission deadline 20 May 2026 | 5 articles | Viewed by 5373 | Submission Open
Keywords: xenobiotics; oxidative stress; free radicals; reactive oxygen species; reactive nitrogen species; antioxidants; glutathione; toxicology; redox metabolism; redox imbalance
(This special issue belongs to the Section Biochemistry)
Microbiome Connections in Age-Related Diseases
edited by Shalini Jain
submission deadline 20 May 2026 | 2 articles | Viewed by 5322 | Submission Open
Keywords: microbiome; aging; age-related diseases; Alzheimer’ s; dementia
(This special issue belongs to the Section Molecular Microbiology)
Extraction, Identification and Quantification of Bioactive Molecules
edited by and Rosario Mare
submission deadline 20 May 2026 | 2 articles | Viewed by 5188 | Submission Open
Keywords: extracts; botanicals; nutraceuticals; bioactive molecules; spectrometry; spectrophotometer; chromatography; western blotting; molecular mechanisms
(This special issue belongs to the Section Molecular Biology)
The Function of Glial Cells in the Nervous System: 2nd Edition
edited by Krista Minéia Wartchow
submission deadline 20 May 2026 | 3 articles | Viewed by 5072 | Submission Open
Keywords: glial cells; glial– neuronal interaction; glial biomarkers; neurodegenerative diseases; therapeutic approaches
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Applications of Technologies and Techniques for the Extraction of Simple Molecules and Compounds
edited by
submission deadline 20 May 2026 | 5 articles | Viewed by 5066 | Submission Open
Keywords: sample preparation; natural product extraction; purification; pollutant extraction; nutraceutical extraction; extraction of environmental indicators; magnetic extraction; green analytical chemistry; liquid– liquid (micro)extraction; cloud point (micro)extraction; solid phase (micro)extraction; pressurized liquid extraction; ultrasound-assisted extraction; microwave-assisted extraction; deep eutectic solvents; supercritical fluid extraction; molecularly imprinted polymers; QuEChERS (quick; easy; cheap; effective; rugged and safe)
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Host Responses to Virus Infection
edited by Hideki Hayashi and Yoshinao Kubo
submission deadline 20 May 2026 | 3 articles | Viewed by 5054 | Submission Open
Keywords: viral infection; host reactions; interferon alpha and beta; interferon gamma; cytokines; vaccine; cytokine storm
(This special issue belongs to the Section Molecular Microbiology)
New Anti-cancer Agents: Design, Synthesis and Applications submission deadline 20 May 2026 | 2 articles | Viewed by 4923 | Submission Open
Keywords: anti-cancer drugs; cancer drug development; cancer therapy; rational drug design; structure– activity relationship; cancer therapeutics; cytotoxicity; apoptosis; anti-tumor activity
(This special issue belongs to the Section Molecular Pharmacology)
Diagnosis and Treatment of Osteoporosis
edited by
submission deadline 20 May 2026 | 3 articles | Viewed by 4680 | Submission Open
Keywords: osteoporosis; diagnosis; dual X-rays absorptiometry; DXA; bone turnover markers; secondary osteoporosis; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bile Acids and Bile Acid Modifications in Health and Disease submission deadline 20 May 2026 | 3 articles | Viewed by 4668 | Submission Open
Keywords: bile acids; bile acid modifications; bile acid signaling; bile acid metabolism; metabolic disorders
(This special issue belongs to the Section Molecular Microbiology)
Molecular and Cellular Therapeutics for Respiratory Diseases
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 4457 | Submission Open
Keywords: lung diseases; cystic fibrosis; chronic obstructive pulmonary disease; asthma; drug delivery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Male Reproductive Physiology, Pathophysiology, and Contraception
edited by Gustavo G. Blanco
submission deadline 20 May 2026 | 2 articles | Viewed by 4362 | Submission Open
Keywords: spermatogenesis; spermiogenesis; testis; epididymis; sperm function; sperm motility; sperm capacitation; acrosome reaction; male reproduction; male fertility; male infertility; male contraception
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancing Cancer Research: Molecular Insights, Diagnostic Innovations and Therapeutic Targets
edited by Jue Wang
submission deadline 20 May 2026 | 2 articles | Viewed by 4278 | Submission Open
Keywords: cancer; carcinogenesis; molecular pathology; signaling transduction; diagnosis; treatment; prognosis; pathogenesis; precision oncology; biomarker discovery; genomic profiling
(This special issue belongs to the Section Molecular Oncology)
Neurological Diseases: From Physiology to Therapy submission deadline 20 May 2026 | 2 articles | Viewed by 4254 | Submission Open
Keywords: neurophysiology; genetics; Alzheimer’ s disease; neurological diseases; neurodegenerative diseases
(This special issue belongs to the Section Molecular Neurobiology)
Glioblastoma: Molecular Pathogenesis and Treatment submission deadline 20 May 2026 | 1 articles | Viewed by 4216 | Submission Open
Keywords: glioblastoma; molecular therapy; pathogenesis; immunotherapy; brain tumor
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Microbiome and Metabolome in the Gastrointestinal Tract, 3rd Edition submission deadline 20 May 2026 | 1 articles | Viewed by 4120 | Submission Open
Keywords: microbiome; dysbiosis; microbiology; immunity; cytokine/chemokine networks; microbiota axes pathways; toxic substances; autoimmunity
(This special issue belongs to the Section Molecular Biology)
New Insights in Artificial Intelligence for Drug Design and Target Discovery
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 4023 | Submission Open
Keywords: pre-trained language models; generative models; drug prediction; binding site prediction; peptides; multi-omics; deep learning; QSAR modeling; molecular dynamics (MD) simulations
(This special issue belongs to the Section Molecular Pharmacology)
Ceramides and Ceramide Kinase
edited by Antonio Gomez-Muñoz
submission deadline 20 May 2026 | 3 articles | Viewed by 3979 | Submission Open
Keywords: cancer; cell survival; ceramides; ceramide 1-phosphate; inflammation
(This special issue belongs to the Section Biochemistry)
New Insights into Chemotherapeutic Agents in Cancer Treatment
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 3962 | Submission Open
Keywords: chemotherapy; molecular mechanisms; signal transduction; apoptosis; drug resistance; biomarkers; DNA damage; targeted therapy; cancer pathways; nanoparticles; nanomedicine; epigenetics
(This special issue belongs to the Section Molecular Pharmacology)
Liposomes: Molecular Marvels in Drug Delivery
edited by and Juyang Huang
submission deadline 20 May 2026 | 1 articles | Viewed by 3907 | Submission Open
Keywords: liposomal drug; targeted delivery; controlled release; hydrogen bonding; long-term stability; archaeosomes; cytotoxicity; lyophilized liposomal drugs
(This special issue belongs to the Section Molecular Biophysics)
The Role of Iodinated Compounds and Molecular Iodine in Human Disease
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 3713 | Submission Open
Keywords: iodine; iodinated compounds; oxidized iodine; oxidized iodine supplement
(This special issue belongs to the Section Biochemistry)
Evolution and Genomics: Relevance to Current Issues
edited by and Sally Lloyd
submission deadline 20 May 2026 | 2 articles | Viewed by 3684 | Submission Open
Keywords: paralogy; synteny; evolution; genomics; duplication; haplotype
(This special issue belongs to the Section Molecular Genetics and Genomics)
Recent Advances in Dementia with Lewy Bodies and Alzheimer’s Disease
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 3367 | Submission Open
Keywords: dementia with Lewy bodies; Alzheimer’ s disease; dementing disorders in advanced age
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Diagnostics in Neurological Diseases submission deadline 20 May 2026 | 2 articles | Viewed by 3310 | Submission Open
Keywords: neurological diseases; biomarkers; translational research; precision medicine; diagnosis; prognosis
(This special issue belongs to the Section Molecular Neurobiology)
Thermodynamic and Spectral Studies of Complexes
edited by Michał Zabiszak
submission deadline 20 May 2026 | 4 articles | Viewed by 3294 | Submission Open
Keywords: spectroscopic techniques; molecular interaction; electronic spectroscopy; solid state chemistry; applications of complex compounds; reaction mechanism; catalytic activity
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Prostate Diseases: Focus on Hormone Therapies and Targeted Interventions
edited by Gabriel Campolina-Silva and Héctor Contreras
submission deadline 20 May 2026 | 1 articles | Viewed by 3279 | Submission Open
Keywords: urinary disease; prostate cancer; hormone; therapeutic strategy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cyclodextrins for Drug/iRNA Co-Delivery
edited by and
submission deadline 20 May 2026 | 1 articles | Viewed by 3243 | Submission Open
Keywords: advanced therapies; antibody-based therapies; active and passive tumor targeting; cancer; conventional chemotherapy; immune system; immunotherapy; immunotoxicity; nanomedicine; nanoparticles; nanotoxicity; tumor immune microenvironment (TIME); tumor microenvironment (TME); cyclodextrins
(This special issue belongs to the Section Macromolecules)
Biomedical Polymer Materials: Design, Synthesis or Applications
edited by Lourdes Franco
submission deadline 20 May 2026 | 1 articles | Viewed by 3182 | Submission Open
Keywords: biomedical polymeric materials; nanoparticles; drug delivery; smart materials; hydrogels; tissue regeneration; therapeutic applications; dendrimers; MOFs; micelles
(This special issue belongs to the Section Materials Science)
RNA Editing/Modification in Health and Disease
edited by Valeriana Cesarini and
submission deadline 20 May 2026 | 2 articles | Viewed by 3181 | Submission Open
Keywords: RNA editing; RNA transport and localization; miRNAs; siRNAs; lncRNAs
(This special issue belongs to the Section Molecular Genetics and Genomics)
Peptides and Peptidomimetics for Targeting Protein-Protein Interactions submission deadline 20 May 2026 | 1 articles | Viewed by 3178 | Submission Open
Keywords: protein– protein interactions; peptide– protein interactions; interactome; proteomics; peptides; modified peptides; peptidomimetics; molecular glues; drug discovery; medicinal chemistry; rule of five; biophysical assays; molecular modelling; cancer; neurodegenerative diseases; orphan diseases; antimicrobial resistance; PROTAC
(This special issue belongs to the Section Biochemistry)
Molecular Insights into Flower Gene Regulation
edited by Wen‑Chieh Tsai
submission deadline 20 May 2026 | 2 articles | Viewed by 3059 | Submission Open
Keywords: floral gene regulation; flowers; homeotic genes; MADSBox; pollination
(This special issue belongs to the Section Molecular Plant Sciences)
The Molecular Basis of Extracellular Vesicles in Health and Diseases—2nd Edition
edited by Taral R. Lunavat
submission deadline 20 May 2026 | 3 articles | Viewed by 2862 | Submission Open
Keywords: exosomes; microvesicles; extracellular vesicles; genetic material; therapeutics; diagnostics; biomarkers; molecular pathway; liquid biopsy; metabolism; omics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Medical Applications of Polymer Materials
edited by Zhen Zhang
submission deadline 20 May 2026 | 2 articles | Viewed by 2803 | Submission Open
Keywords: medical polymers; drug delivery; tissue engineering; medical devices; diagnostics
(This special issue belongs to the Section Macromolecules)
Lymphedema: From Mechanism to Treatment
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 2670 | Submission Open
Keywords: lymphedema; lymphatic dysfunction; molecular mechanisms; cell signaling; diagnostic imaging; biomarkers; therapeutic interventions; inflammation; adipose tissue accumulation; fibrosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancing Molecular Science Through Reproducible qPCR: MIQE Guidelines and Beyond
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 2591 | Submission Open
Keywords: MIQE; qPCR; reverse transcription
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomarkers in Diabetes Mellitus: From Discovery to Clinical Application submission deadline 20 May 2026 | 2 articles | Viewed by 2557 | Submission Open
Keywords: diabetes mellitus; biomarkers; diabetes complications; omics technologies; risk stratification; therapeutic response; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactive Food Compounds in the Prevention and Treatment of Non-Communicable Diseases
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 2533 | Submission Open
Keywords: bioactive compounds; dietary fiber; polyphenols; sulfur compounds; antioxidant; reduce oxidative stress; inflammation; non-communicable diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Advances in the Synthesis and Medical Application of Biomaterials
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 2440 | Submission Open
Keywords: nanostructured biomaterials; bioceramics; bioactive; biodegradable; resorbable materials; biomimetic materials; biocompatibility
(This special issue belongs to the Section Materials Science)
Molecular Computational Research in Pharmacological Structure–Efficacy
edited by and Jerônimo Lameira
submission deadline 20 May 2026 | 2 articles | Viewed by 2390 | Submission Open
Keywords: molecular modeling; structure– activity relationship (SAR); pharmacological efficacy; quantum chemistry; molecular dynamics; free energy calculations; drug design; enzyme inhibition; ligand– receptor interactions; computational pharmacology
(This special issue belongs to the Section Molecular Pharmacology)
Cell Organelle Stress Responses and Implications in Human Diseases
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 2274 | Submission Open
Keywords: organelle stresses; mitochondria; ER; lysosome; human diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Liver Diseases: Causes, Molecular Mechanism and Treatment/Prevention
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 2250 | Submission Open
Keywords: liver diseases; pathophysiology; molecular mechanisms; genetics and epigenetics; non-alcoholic fatty liver disease (NAFLD); hepatitis; liver injury and repair; gene therapy; pharmacological interventions; treatment and prevention; gut– liver axis; spleen– liver axis; alcoholic liver disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Latest Insights into Glycobiology submission deadline 20 May 2026 | 2 articles | Viewed by 2235 | Submission Open
Keywords: glycosylation; biomarkers; separation techniques; mass spectrometry; multivariate data analysis
(This special issue belongs to the Section Molecular Biology)
Advancing Interdisciplinary Science with Quantum/Molecular Mechanics (QM/MM) in Computational Chemistry
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 2225 | Submission Open
Keywords: QM/MM; computational methods; electronic structure; f-electron systems; materials science; nanoclusters; nuclear medicine; computational catalysis; drug design; machine learning in computational chemistry
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms and Therapeutic Targets in Cardiovascular Health and Cardiotoxicity
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 2218 | Submission Open
Keywords: cardiovascular; ischemia; heart failure; arrhythmogenesis; myocardial remodeling; endothelial dysfunction; cardiology; cardio-oncology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Life’s Thermodynamics: Cells and Evolution
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 2138 | Submission Open
Keywords: cell growth and decay; cell aging; system biology; mathematical modeling; ecological modeling; dissipative adaptation; maximum power principle; evolution of microbial fitness; energy balance in microbial cultures
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Recent Advances in Graphene-Based Nanocomposites and Perspectives on Their Design
edited by Aleksey E. Kuznetsov
submission deadline 20 May 2026 | 2 articles | Viewed by 2131 | Submission Open
Keywords: graphene; graphene oxide; nanocomposite; synthesis; computational study; characterization; application; design
(This special issue belongs to the Section Molecular Nanoscience)
Emerging Biomaterials for Cartilage Regeneration
edited by
submission deadline 20 May 2026 | 1 articles | Viewed by 2025 | Submission Open
Keywords: osteoarthritis; glycosaminoglycans; biomaterials; cartilage regeneration; mesenchymal cells; chondrocytes
(This special issue belongs to the Section Biochemistry)
Next-Generation Hydrogels: Innovations in Biofunctionalization and Personalization for Targeted Biomedical Therapies
edited by and Bohan Yin
submission deadline 20 May 2026 | 1 articles | Viewed by 1980 | Submission Open
Keywords: biofunctionalization hydrogels; personalized hydrogels; smart hydrogel development; 3D/4D bioprinting of hydrogels; AI-driven hydrogel design; dynamic hydrogel systems; hydrogel-based vaccines and immunotherapies; smart hydrogels for controlled release
(This special issue belongs to the Section Macromolecules)
Cancer-Driving Molecules: From Molecular Mechanisms to Novel Therapeutics
edited by
submission deadline 20 May 2026 | 2 articles | Viewed by 1953 | Submission Open
Keywords: cancer; mechanism of action; tumor microenvironment; immune system; DNA/RNA/protein; small-molecule probes; activation/inhibition; biological activity
(This special issue belongs to the Section Molecular Oncology)
The Role of Lipoprotein in Cardiovascular Disease submission deadline 20 May 2026 | 1 articles | Viewed by 1893 | Submission Open
Keywords: lipoprotein; cardiovascular disease; atherosclerosis; lipid metabolism; HDL; LDL; VLDL; Lp(a); TRLs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Antiviral Drug Targets: Structure, Function, and Drug Design—3rd Edition
edited by and
submission deadline 20 May 2026 | 2 articles | Viewed by 1773 | Submission Open
Keywords: viral infections; drug design; protein structures; functional studies; viruses; antiviral drugs
(This special issue belongs to the Section Molecular Pharmacology)
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