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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Current Research on Plant Hormones Affecting Crop Yield and Fruit Quality submission deadline 20 Dec 2025 | 1 articles | Viewed by 5234 | Submission Open
Keywords: auxins; gibberellins; citokynis; ethylene; yield; quality; antioxidant; storage
(This special issue belongs to the Section Molecular Plant Sciences)
Systemic Sclerosis: New Insight into Pathogenesis, Molecular and Immune Mechanisms
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 5019 | Submission Open
Keywords: systemic sclerosis; autoimmunity; inflammation; fibrosis; pathophysiology and treatment; profibrotic signaling; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Antifungal Drug Discovery: Progresses, Challenges, Opportunities, 2nd Edition
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 5009 | Submission Open
Keywords: antifungal drugs; fungal infections; drug design; drug discovery; targeted therapy; drug resistance; fungal drug targets; neglected tropical diseases
(This special issue belongs to the Section Molecular Pharmacology)
Antimicrobial Nanomaterials: Approaches, Strategies and Applications
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 4798 | Submission Open
Keywords: nanotechnology; biocides; antimicrobials; controlled release; drug delivery; antimicrobial agents; antimicrobial resistance; infection; nanoparticles
(This special issue belongs to the Section Materials Science)
Data Science in Cancer Genomics and Precision Medicine: 2nd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 4737 | Submission Open
Keywords: cancer genomics; big data; tumor immunology; translational oncology; precision medicine; next-generation sequencing; omics; cancer genomic datasets
(This special issue belongs to the Section Molecular Genetics and Genomics)
Biomarkers for Cardiovascular Risk Prediction
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 4726 | Submission Open
Keywords: biomarker; cardiovascular disease; risk stratification; inflammation; vascular damage; micro-RNA; therapy; artificial intelligence
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biochemistry and Molecular Biology of Coronaviruses
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 4700 | Submission Open
Keywords: SARS-CoV; MERS-CoV; COVID-19; RNA viruses; infection; antivirals; vaccines; therapeutics; host-virus interactions
(This special issue belongs to the Section Molecular Microbiology)
p53—Oncogene, Tumor Suppressor Gene, Guardian of the Genome and the Cell
edited by Przemyslaw Bozko
submission deadline 20 Dec 2025 | 3 articles | Viewed by 4644 | Submission Open
Keywords: p53; oncogene; tumor suppressor gene; tumor formation; anticancer therapy
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Biology of Fish Stress
edited by , and
submission deadline 20 Dec 2025 | 4 articles | Viewed by 4630 | Submission Open
Keywords: fish stress; molecular biology; omics; apoptosis; inflammation
(This special issue belongs to the Section Molecular Biology)
Signal Transduction Mechanism in Plant Disease and Immunity: 2nd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 4595 | Submission Open
Keywords: plant disease resistance; biotic stress; pathogen; plant-microbe interaction; priming; signal transduction; phytohormone; proteomics
(This special issue belongs to the Section Molecular Plant Sciences)
The Role of Epigenetics in Genome Maintenance and Its Relationship to Organismal Aging and Age-Related Diseases
edited by Berta Vázquez and Gerardo Ferrer
submission deadline 20 Dec 2025 | 3 articles | Viewed by 4525 | Submission Open
Keywords: chromatin; DNA damage; DNA repair; gene transcription; DNA replication; chromosome segregation; genome integrity; chromosome organization
(This special issue belongs to the Section Molecular Genetics and Genomics)
Recent Advances in Organic Chemistry: Molecule Synthesis and Reactions (2nd Edition) submission deadline 20 Dec 2025 | 3 articles | Viewed by 4520 | Submission Open
Keywords: bioactive natural products; organocatalysis; photoredox reactions; free-radical reactions; organometallic reactions; organic synthesis
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Advances in Secondary Metabolites in Plants
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 4491 | Submission Open
Keywords: specialized metabolites; biosynthesis pathways; pharmacological applications; medicinal plants; plant stress resistance; abiotic and biotic elicitors; chemometric analysis; plant biotechnology; therapeutic potential; plant signaling and communication
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Understanding Molecular Mechanisms Involved in Chronic Kidney Injury and Repair
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 4413 | Submission Open
Keywords: kidney disease; ischemic kidney injury; renal fibrosis; obesity; inflammation; oxidative stress; autophagy; senescence; cell death; small ncRNA
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Toxicity Mechanism of Emerging Pollutants: 2nd Edition submission deadline 20 Dec 2025 | 4 articles | Viewed by 4407 | Submission Open
Keywords: emerging pollutant; toxicology; cancer; EDC; pesticides; microplastic; human cell lines; environment; molecular mechanisms
(This special issue belongs to the Section Molecular Toxicology)
Neutrophil Extracellular Traps (NETs) in Immunity and Diseases, 3rd Edition
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 4406 | Submission Open
Keywords: neutrophils; neutrophil functions; neutrophil extracellular traps (NETs); NET biology; NETs in autoimmune diseases; NETs in immune response; NETs in the development and progression of cancer diseases; NETs in immunothrombosis; degradation of NETs
(This special issue belongs to the Section Molecular Immunology)
New Advances in Cancer Genomics
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 4339 | Submission Open
Keywords: cancer genomics; biomarker discovery; precision oncology; KRAS and undruggable targets; artificial intelligence in oncology; multi-omics data integration; drug discovery
(This special issue belongs to the Section Molecular Biology)
Emerging Insights into Phytohormone Signaling in Plants
edited by Meng Zhang
submission deadline 20 Dec 2025 | 5 articles | Viewed by 4324 | Submission Open
Keywords: phytohormone; signal transduction; evolutionary and functional diversity; implications for plant science and agriculture
(This special issue belongs to the Section Molecular Plant Sciences)
Pharmacological Treatment of Neuroinflammation
edited by Beatrice Polini
submission deadline 20 Dec 2025 | 2 articles | Viewed by 4300 | Submission Open
Keywords: microglia; neuroinflammation; neurodegeneration; Alzheimer’ s disease; Parkinson’ s disease; therapeutic; natural molecules
(This special issue belongs to the Section Molecular Neurobiology)
Psoriasis: Molecular Research and Novel Therapy
edited by Tsen-Fang Tsai
submission deadline 20 Dec 2025 | 1 articles | Viewed by 4300 | Submission Open
Keywords: psoriasis; pathogenesis; treatment; biologics; novel therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in 3D Tumor Models for Cancer Research submission deadline 20 Dec 2025 | 3 articles | Viewed by 4272 | Submission Open
Keywords: 3D systems; cancer research; spheroids; organoids; organ-on-chip; scaffolds; tissue engineering; biomedical technologies; tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
Molecular Insights: Transitioning Fertility Research from the Laboratory to Clinical Practice
edited by Ekaterini Domali
submission deadline 20 Dec 2025 | 1 articles | Viewed by 4227 | Submission Open
Keywords: IVF/ICSI; male infertility; female infertility; fertility outcomes; endocrine disruptors; oxidative and reductive stress; molecular biology; biomarkers; proteomics; metabolomics; and transcriptomics; cell lines; early pregnancy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Latest Advances in Diabetes Research and Practice
edited by Ezekiel Uba Nwose
submission deadline 20 Dec 2025 | 2 articles | Viewed by 4218 | Submission Open
Keywords: diabetes mellitus; cardiovascular risk; metabolic syndrome; antioxidants; oxidative stress; antiplatelet monitoring; evidence-based medicine; laboratory medicine
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Ovarian Cancer: Pathogenesis, Biomarkers and Treatment
edited by Alessandro Antonio Buda
submission deadline 20 Dec 2025 | 2 articles | Viewed by 4059 | Submission Open
Keywords: ovarian cancer; radiotherapy; diagnosis; prevention; treatment; fertility sparing
(This special issue belongs to the Section Molecular Oncology)
Pathophysiology and Treatment of Alzheimer's Disease
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 4054 | Submission Open
Keywords: Alzheimer's disease; Alzheimer’ s dementia; neurodegeneration; AD; pathogenesis; cure for AD
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Arthritis: Focus on Pathologies, Symptoms and Therapy submission deadline 20 Dec 2025 | 1 articles | Viewed by 4053 | Submission Open
Keywords: rheumatoid arthritis; autoimmune; pathogenesis; strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Rapeseed: Genetic Breeding, Key Trait Mining and Genome
edited by Hongbo Chao
submission deadline 20 Dec 2025 | 3 articles | Viewed by 4020 | Submission Open
Keywords: rapeseed (Brassica napus L.); genetic breeding; genomic improvement; molecular markers; genome-wide association studies (GWAS); multi-omics integration; CRISPR gene editing; marker-assisted selection (MAS); stress resistance traits; yield and oil content improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Power Up Plant Genetic Research with Genomic Data: 3rd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 4004 | Submission Open
Keywords: genome sequencing; optical mapping; genome editing; population genomics; genome-wide; association mapping; functional genomics; epigenomics; genetic interaction; chromatin; biodiversity
(This special issue belongs to the Section Molecular Genetics and Genomics)
Antiviral Strategies Targeting Capsid Proteins: Intervention from Assembly to Function
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 3913 | Submission Open
Keywords: viral capsid protein; assembly modulator/intervention; virus variants; antiviral therapeutics; assembly– disassembly
(This special issue belongs to the Section Macromolecules)
The Role of Mg Homeostasis in Disease: 2nd Edition submission deadline 20 Dec 2025 | 1 articles | Viewed by 3861 | Submission Open
Keywords: magnesium; chronic diseases; diabetes; bone disease; mineral metabolism; renal disease; inflammation; cardiovascular disease
(This special issue belongs to the Section Biochemistry)
Novel Trends in the Research of Molecules Involved in Skin Inflammation and Dermatologic Conditions submission deadline 20 Dec 2025 | 2 articles | Viewed by 3855 | Submission Open
Keywords: atopic dermatitis; contact dermatitis; psoriasis; urticaria; eczema; acne; rosacea; seborrheic dermatitis; drug-induced reaction; prurigo nodularis; lichen; hidradenitis suppurativa; alopecia; chronic urticaria; skin tumor; angioedema; venous ulcer; HPV skin manifestations; skin infection; vitiligo
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Veterinary Science
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 3786 | Submission Open
Keywords: forensic pathology and necropsy; forensic toxicology; DNA analysis in veterinary forensics; the role of veterinarians in legal investigations; case studies in veterinary forensics
(This special issue belongs to the Section Molecular Toxicology)
Advances in Vegetable Breeding and Molecular Research
edited by and
submission deadline 20 Dec 2025 | 3 articles | Viewed by 3641 | Submission Open
Keywords: vegetable breeding; gene editing; omics; molecular breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Innovative Research on Nutrition and Epigenetics in Cancer
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 3478 | Submission Open
Keywords: diet; nutrition; epigenetics; cancer; cancer therapy; lifestyle
(This special issue belongs to the Section Molecular Oncology)
Design of Bioactive Agents and Interaction with Biological Systems
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 3477 | Submission Open
Keywords: natural and synthetic compounds; bioactive agents and materials; design and discovery; targeting; intermolecular interactions; omics; structure and dynamics of biomolecules; theoretical analysis of biomolecular structures; analytical and biophysical methods; molecular biology/biochemistry; chemical biology/biological chemistry
(This special issue belongs to the Section Molecular Biology)
The Use of Molecular Biology in the Targeted Prevention, Diagnosis and Therapy of Microbial Infections submission deadline 20 Dec 2025 | 1 articles | Viewed by 3297 | Submission Open
Keywords: microbial infections; AMR; molecular biology; One Health; microbiome
(This special issue belongs to the Section Molecular Microbiology)
New Insights of Autophagy and Apoptosis in Cells submission deadline 20 Dec 2025 | 2 articles | Viewed by 3295 | Submission Open
Keywords: autophagy; apoptosis; signal transduction; cell survival
(This special issue belongs to the Section Molecular Biology)
Oxidative Stress and Inflammation in the Tissue Repair—Pathways and Biotechnologies
edited by Reggiani Vilela Gonçalves and Rômulo Dias Novaes
submission deadline 20 Dec 2025 | 1 articles | Viewed by 3256 | Submission Open
Keywords: oxidative stress; inflammasome; cytokines; angiogenesis; remodeling; molecular pathways; apoptotic alterations; diabetes; tissue repair  
(This special issue belongs to the Section Biochemistry)
Properties and Applications of Nanoparticles and Nanomaterials: 3rd Edition
edited by Xiaogang Li
submission deadline 20 Dec 2025 | 3 articles | Viewed by 3214 | Submission Open
Keywords: nanostructures; nanoparticles; microstructure characterization; material design; evaluation of mechanical properties; applications of nanomaterials
(This special issue belongs to the Section Molecular Nanoscience)
Histopathological and Cytological Biomarkers for Breast and Gynecologic Cancers
edited by Ilias P. Nikas, and
submission deadline 20 Dec 2025 | 2 articles | Viewed by 3158 | Submission Open
Keywords: pathology; cytopathology; malignant effusions; biomarker; breast cancer; ovarian cancer; endometrial cancer; cervical cancer; metastasis; immunohistochemistry; immunocytochemistry; immunotherapy; genomics; proteomics; personalized medicine; prognosis and therapy; digital pathology; artificial intelligence; machine learning  
(This special issue belongs to the Section Molecular Oncology)
New Insight into Radiation Biology and Radiation Exposure
edited by Lynnette Cary
submission deadline 20 Dec 2025 | 2 articles | Viewed by 3152 | Submission Open
Keywords: ionizing radiation; radiation biomarkers; radionuclide; medical countermeasure
(This special issue belongs to the Section Molecular Biology)
Innovative Approaches in Organic Synthesis and Functional Materials: From Design to Biological Impact submission deadline 20 Dec 2025 | 3 articles | Viewed by 3146 | Submission Open
Keywords: organic synthesis; bioactive molecules; functional materials; molecular informatics; biological activity; molecular docking; computational chemistry; drug design; medicinal chemistry; quantitative structure– activity relationships (QSARs); environmental applications; sustainable chemistry; natural products
(This special issue belongs to the Section Molecular Informatics)
The Role of Metabolism-Related Pathways in Animal Growth, Development, Disease and Behavior
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 3121 | Submission Open
Keywords: metabolism pathway; signal pathway; animal development; animal behavior; animal disease
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Extraction, Isolation and Identification of Natural Chemicals
edited by Jiaozhen Zhang
submission deadline 20 Dec 2025 | 2 articles | Viewed by 3104 | Submission Open
Keywords: extraction; isolation; identification; natural chemicals; biological activities
(This special issue belongs to the Section Biochemistry)
Cardioprotection and Mitochondrial Signaling: Insights from Molecular Mechanisms to Therapeutic Strategies
edited by Cecilia Zazueta
submission deadline 20 Dec 2025 | 2 articles | Viewed by 3024 | Submission Open
Keywords: cardioprotection; mitochondrial signaling; mitochondrial dysfunction; heart failure; ischemia/reperfusion; mitochondria; reactive oxygen species
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Drug Delivery Systems in Veterinary Medicine: Innovations and Applications
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 3023 | Submission Open
Keywords: design of novel veterinary drug delivery systems; methods of preparing a veterinary drug delivery system; mechanisms of action of veterinary drug delivery systems; impact of veterinary drug delivery systems on in vivo processes of veterinary drugs; clinical evaluation of veterinary drug delivery systems
(This special issue belongs to the Section Molecular Pharmacology)
Diseases in Humans and Animals: From Emergence to Translational Medicine
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 3005 | Submission Open
Keywords: animal diseases; human diseases; viruses; bacteria; translational medicine; environment; zoonosis; One Health; disease models
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Development and Validation of New Analytical Methods for the Determination of Drugs and Their Metabolites
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2969 | Submission Open
Keywords: drugs; drug formulations; pharmacokinetics; metabolism studies; analytical techniques
(This special issue belongs to the Section Molecular Pharmacology)
Future Perspectives and Challenges in Molecular Research of Glioma
edited by Shanchun Guo
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2940 | Submission Open
Keywords: gliomas; genetic and epigenetic changes; molecular mechanisms; immunotherapy; innovative therapeutic strategies
(This special issue belongs to the Section Molecular Neurobiology)
Viral Diseases of the Respiratory System—Molecular Mechanisms and Pathogenesis: 3rd Edition
edited by
submission deadline 20 Dec 2025 | 4 articles | Viewed by 2924 | Submission Open
Keywords: respiratory diseases; pneumonia; pneumotropic viruses; pathogenesis; host– pathogen interaction; pulmonary pathology; immunopathology; immunity; disease prevention; treatment; zoonotic diseases; antiviral therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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