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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Radiobiology—New Advances

edited by

Marco Calvaruso

and

Luigi Minafra

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2810 | Submission Open

Keywords: radiobiology; radiotherapy; radiosensitizing agents; radioresistance; DNA damage; FLASH radiotherapy; particle therapy

(This special issue belongs to the Section Molecular Biology)

Molecular Research in Triple-Negative Breast Cancer: 2nd Edition

edited by

Yong-Moon Lee

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2790 | Submission Open

Keywords: triple negative breast cancer; lymph node metastasis; PMP22; prediction model using deep learning

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Treatment of Chronic Kidney Disease

edited by Xinming Chen

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2741 | Submission Open

Keywords: diabetes; cardiovascular diseases; nephrology; diabetic nephropathy

(This special issue belongs to the Section Molecular Biology)

Mitochondria and Energy Metabolism Reprogramming in Diseases

edited by

Nadège Bellance

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2728 | Submission Open

Keywords: mitochondrial dysfunctions; energy metabolism; pathophysiological mechanisms; therapeutic targets; physiology of organelle

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Genomic Aspects of Viral Pathogens

edited by

Joanna Dąbrowska

submission deadline 20 Apr 2026 | 3 articles | Viewed by 2712 | Submission Open

Keywords: viral pathogens; genetic and molecular mechanisms; viral infection; viral replication; host interaction

(This special issue belongs to the Section Molecular Microbiology)

Advanced Molecular Research in Cardiology and Treatment Approaches

edited by Ludger Hauck

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2680 | Submission Open

Keywords: TAp63; EzH2; histone methyltransferase; cardiomyocyte proliferation; myocardial infarction; heart regeneration; heart repair; epigenetic regulation; cardiac regeneration; Skp2-p27KIP1 pathway

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

COVID-19: Molecular Research and Novel Therapy

edited by

Mihaela Chivu-Economescu

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2649 | Submission Open

Keywords: SARS-CoV-2; virus-host interaction; immune response; antiviral agents; vaccines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research on Luminescent Materials and Their Luminescence Mechanism

edited by

María Teresa Colomer

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2643 | Submission Open

Keywords: luminescence; molecular/ionic level; mechanism

(This special issue belongs to the Section Materials Science)

The Role of the Endocannabinoid System in Reward- and Addiction-Related Neuroplasticity

edited by

Francisco Navarrete-Rueda

and

María S. García Gutiérrez

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2625 | Submission Open

Keywords: endocannabinoid system; neuroplasticity; reward; addiction; biomarker; therapeutic approach

(This special issue belongs to the Section Molecular Neurobiology)

Explore Marine Biodiversity: Discover Insights from Genomics and Transcriptomics

edited by

Maria Sirakov

and Ambrosino Luca

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2530 | Submission Open

Keywords: comparative genomics; functional genomics; transcriptomics; gene expression; adaptation; population genomics; marine biodiversity; evolution

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advanced Molecular Diagnostic Approaches for Neurodevelopmental Disorders: Applications and Future Perspectives

edited by

Barbara Lombardo

and Michele Pinelli

submission deadline 20 Apr 2026 | 3 articles | Viewed by 2494 | Submission Open

Keywords: neurodevelopmental disorders; array CGH; NGS

(This special issue belongs to the Section Molecular Neurobiology)

Peptide and Protein Drugs Against Infectious Diseases and Allergic Diseases

edited by

Xiumin Wang

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2493 | Submission Open

Keywords: peptide and protein drugs; infectious diseases; allergic diseases; hormones; antimicrobial peptides; neuropeptides; cell-penetrating peptides; enzyme inhibitors; vaccines; antibodies

(This special issue belongs to the Section Molecular Pharmacology)

Zebrafish Model for Neurological Research

edited by

Mattia Toni

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2458 | Submission Open

Keywords: zebrafish ; Danio rerio ; brain ; nervous system

(This special issue belongs to the Section Molecular Neurobiology)

Current Trends in Redox Physiology Research

edited by Fotios Tekos

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2451 | Submission Open

Keywords: redox biology; oxidative stress; antioxidant mechanisms; redox signaling; cellular homeostasis; inflammation and redox; nutritional redox modulation; environmental toxicology and redox; mitochondrial dysfunction; oxidative stress biomarkers

(This special issue belongs to the Section Biochemistry)

New Insights and Research on Nutrition and Obesity

edited by

Giovanna Bermano

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2378 | Submission Open

Keywords: nutrition; obesity; malnutrition; overnutrition; molecular and cellular mechanisms; nutrient– gene interactions; metabolic disorders

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Microbial Dynamics in Agroforestry for Resilience and Climate Adaptation

edited by

Amrita Chakraborty

and

Amit Roy

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2375 | Submission Open

Keywords: agroforestry; soil microbes; plant-microbe interactions; microbial influence; microbiomes; insect-microbe interactions; horizontal gene transfer

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights into Ubiquitination and Deubiquitination in Plants

edited by

Hongyong Fu

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2200 | Submission Open

Keywords: ubiquitin; E1; E2; E3; deubiquitination; proteolysis; plants

(This special issue belongs to the Section Biochemistry)

Research Advances in Antibiotic Resistance

edited by

José Pascual Abad

and

Irma Marín

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2198 | Submission Open

Keywords: antibiotic resistance; resistant pathogenic microorganisms; One Health; prevalence of antibiotic-resistant microorganisms; multidrug resistance; antibiotic resistance levels; alternative anti-infectious strategies and compounds; antibiotic-resistant genes; mechanisms of antimicrobial resistance

(This special issue belongs to the Section Molecular Microbiology)

Genetic Prediction of Risk of Common Diseases

edited by

Grant Morahan

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2180 | Submission Open

Keywords: complex genetic diseases; cancer; heart disease; diabetes; dementia; polygenic risk score; genetic risk signatures

(This special issue belongs to the Section Molecular Genetics and Genomics)

Complex Interactions of Plants with Other Organisms: Particular Attention to Carnivorous and Parasitic Plants

edited by

Bartosz Płachno

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2156 | Submission Open

Keywords: carnivorous plants; parasitic plants; mycotrophic plants; hosts; phytochemistry; molecular biology; genome evolution; organ structure; cellular; genomic

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Microbial Genomics: Insights from Whole Genomes and Metagenomes

edited by

Marcos Quintela Baluja

submission deadline 20 Apr 2026 | 2 articles | Viewed by 2097 | Submission Open

Keywords: microbial evolution; whole-genome sequencing; metagenomics; horizontal gene transfer; antimicrobial resistance; computational genomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cellular and Molecular Mechanisms in Inflammatory Bowel Disease

edited by Michael Bording-Jorgensen

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2092 | Submission Open

Keywords: IBD; cytokines; microbiome; Crohn’ s disease; ulcerative colitis; dysbiosis; mucosal immunity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomarker Discovery in Oral Diseases: Integrating Connected Health and Digital Biomarkers for Advanced Diagnostics and Personalized Care

edited by

Shahnawaz Khijmatgar

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2089 | Submission Open

Keywords: oral diseases; biomarker; proteomics; metabolomics

(This special issue belongs to the Section Molecular Biology)

Advancements in Molecular Science, Material Analysis, and Surface Treatments: Paving the Way for Future Technological Innovations

edited by

Fadoua El-Hajjaji

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2060 | Submission Open

Keywords: materials; surface treatments; corrosion; nanomaterials; coatings; molecular interactions; deposition

(This special issue belongs to the Section Materials Science)

Multiple Sclerosis: Molecular Basis and New Therapy

edited by Vito A. G. Ricigliano

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2031 | Submission Open

Keywords: multiple sclerosis; inflammation; microglia; Epstein– Barr virus; neurodegeneration; remyelination; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biochemical Advancements in Filler Technology and Their Impact on Tissue Engineering

edited by Samuel J. Lin

submission deadline 20 Apr 2026 | 1 articles | Viewed by 2012 | Submission Open

Keywords: biochemical filler technology; tissue regeneration; bioactive materials; injectable scaffolds; molecular signaling in tissue engineering; biomaterials for soft tissue repair; filler– cell interactions; regenerative esthetics

(This special issue belongs to the Section Biochemistry)

Advancement of Understanding Alzheimer’s Disease Susceptibility and Novel Drug Targets

edited by Kunie Ando and Jean-Pierre Brion

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1998 | Submission Open

Keywords: Alzheimer’ s disease; neurodegenerative diseases; tau; amyloid; inflammation; disease modifying treatments; biomarkers; genetic variants; risk factors; mechanisms; protein– protein interactions; post-translational modifications

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Biology and the Genetic Breeding of Aquatic Animals: Breakthroughs and Challenges (2nd Edition)

edited by

Hongyan Xu

submission deadline 20 Apr 2026 | 4 articles | Viewed by 1976 | Submission Open

Keywords: transgenic; genetic breeding; omics; gene expression and regulation; aquatic animals

(This special issue belongs to the Section Molecular Biology)

Applications of Mass Spectrometry in the Analysis of Bioactive and Plant Organic Compounds

edited by

Marisabel Mecca

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1961 | Submission Open

Keywords: mass spectrometry; VOCs; bioactive compounds; plant organic compounds; pharmaceutical research; metabolites

(This special issue belongs to the Section Biochemistry)

Accelerating Therapeutic Innovation: Advances in Computer-Aided Drug Discovery

edited by Pietro Delre and

Antonio Lavecchia

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1944 | Submission Open

Keywords: CADD; drug discovery; machine learning; virtual screening; drug-target interaction

(This special issue belongs to the Section Molecular Informatics)

Pathogenic Proteins in Neurodegenerative Diseases: From Pathogenesis to Therapeutic Innovations

edited by

Minseok Song

and

Nidhi Puranik

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1934 | Submission Open

Keywords: Alzheimer’ s disease; Parkinson’ s disease; amyotrophic lateral sclerosis; frontotemporal dementia; lewy bodies dementia; amyloid β -protein; τ -protein; α -synuclein; TDP-43; neurotransmitter; neuropeptide; protein misfolding; protein Homeostasis; neuroinflammatory proteins; post-translational modifications

(This special issue belongs to the Section Molecular Neurobiology)

In Silico Approaches to Drug Design and Discovery

edited by

Alejandro Speck-Planche

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1931 | Submission Open

Keywords: chemoinformatics; computational de novo design and generative AI methods; machine learning; deep learning; molecular modeling; pharmacophore modeling; molecular docking; molecular dynamics; QSAR/QSPR; virtual screening

(This special issue belongs to the Section Molecular Informatics)

Exploring Amazon Bioactives: Novel Anti-Pathogen Therapeutics and Pharmaceutical Breakthroughs

edited by Marta Chagas Monteiro,

Nélio Teixeira Machado

and Pedro Roosevelt Romão

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1929 | Submission Open

Keywords: waste biomass; thermochemical processes; bio-oils; phenolic compounds; anti-inflammatory actions; antiviral mechanisms; cancer; cytokine/chemokine regulation; inflammatory conditions/diseases; innate immunity; immune response; immunomodulatory and anti-infective effects; immunomodulation; immunotoxicology; medicinal chemistry; neglected tropical diseases; parasitic disease; purinergic signaling

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Functional Polymeric Materials: From Synthesis to Applications: 2nd Edition

edited by

Marta Fernández-García

and

Alexandra Muñoz-Bonilla

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1893 | Submission Open

Keywords: natural polymers; bio-based polymers; block copolymers; micelles; polymer chemistry; (hydro)gels; (bio)applications; degradability

(This special issue belongs to the Section Materials Science)

Transforming in Cancer Therapy: Advances in Immunotherapy and Tyrosine Kinase Inhibitors

edited by

Walid Shalata

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1890 | Submission Open

Keywords: tyrosine kinase inhibitors; immunotherapy; monoclonal antibodies; CAR-T cells

(This special issue belongs to the Section Molecular Oncology)

Forest Tree Genetics, Breeding and Environmental Adaption

edited by

Jingli Yang

and

Huiyu Li

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1877 | Submission Open

Keywords: forest trees; genetic breeding; biotic stress; abiotic stress; tree physiology; gene regulation; genetic engineering

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in Neuroimaging

edited by

Chrissa Sioka

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1846 | Submission Open

Keywords: positron emission tomography pulmonary immunology; single photon emission computed tomography; artificial intelligence; neuro-oncology imaging; neurodegenerative disorders imaging; molecular neuroimaging

(This special issue belongs to the Section Molecular Neurobiology)

New Insights into Lactoferrin: 2nd Edition

edited by

Antimo Cutone

and

Giovanni Musci

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1840 | Submission Open

Keywords: lactoferrin; lactoferrin structure; lactoferrin functions; infection; inflammation; iron homeostasis; oxidative stress; lactoferrin bioavailability

(This special issue belongs to the Section Molecular Immunology)

Heat Shock Proteins (HSPs): Biological Functions and Mechanisms of Actions

edited by

Soumya Patnaik

and

Gregory Blatch

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1834 | Submission Open

Keywords: heat shock proteins; apoptosis; immune cell activation; stress responses; misfolded proteins; cellular chaperones; cell signaling

(This special issue belongs to the Section Biochemistry)

Molecular Perspectives on the Synthesis and Application of Hydrogel Materials

edited by

Jieping Fan

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1804 | Submission Open

Keywords: hydrogels; molecular basis; polymeric networks; supermolecular chemistry; three-dimensional structure; mechanical strength; rheologic properties; biomaterial

(This special issue belongs to the Section Materials Science)

Application of Mass Spectrometry and Chromatography in Drug Monitoring

edited by Carsten Müller

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1803 | Submission Open

Keywords: therapeutic drug monitoring; method validation; pharmacometrics; pediatric clinical pharmacology; laboratory developed tests; clinical mass spectrometry; functional tests; isobars; triple quad mass spectrometry; HR-MS; biomarker; drugs of abuse; therapeutic drugs; metabolites

(This special issue belongs to the Section Biochemistry)

Future Challenges and Innovation in Gynecological Oncology

edited by

Alejandro Herreros-Pomares

submission deadline 20 Apr 2026 | 3 articles | Viewed by 1768 | Submission Open

Keywords: gynecologic oncology; molecular biomarkers; personalized medicine; ovarian cancer; immunotherapy; tumor microenvironment; drug resistance; translational research

(This special issue belongs to the Section Molecular Oncology)

Advances in the Purinergic System

edited by Margarete Dulce Bagatini

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1753 | Submission Open

Keywords: purinergic system; receptors; ectonucleotidases; CD39; CD73; purinergic signaling

(This special issue belongs to the Section Biochemistry)

Recent Progress in Extracellular Vesicles

edited by

Regina Golan-Gerstl

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1751 | Submission Open

Keywords: extracellular vesicles (EVs); macrovesicles; exosomes; cell– cell comunication

(This special issue belongs to the Section Molecular Biology)

Interplay of Metabolism and Inflammation in Gastrointestinal Disease

edited by Marios N. Papadakis and

Stavros P. Papadakos

submission deadline 20 Apr 2026 | Viewed by 1736 | Submission Open

Keywords: gastrointestinal diseases; inflammation; metabolic dysregulation; metabolic processes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathology and Next-Generation Biomarkers in Nephrology

edited by

Marijn Speeckaert

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1694 | Submission Open

Keywords: nephrology; genetic mutations; epigenetics; next-generation biomarkers; proteomics; metabolomics; single-cell sequencing; spatial transcriptomics; liquid biopsy; cfDNA; exosomes; microRNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional Proteomics: Insights from Biomedical Applications and Beyond

edited by

Elva Morretta

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1692 | Submission Open

Keywords: functional proteomics; drug discovery; biomedicine; biomarker identification; protein molecular functions; pathway investigation

(This special issue belongs to the Section Molecular Immunology)

Updates and Advances in the Field of Glioblastomas: Mechanisms, Microenvironment and Treatments

edited by

Samantha Epistolio

submission deadline 20 Apr 2026 | 2 articles | Viewed by 1662 | Submission Open

Keywords: GBM; molecular classification; pediatric diffuse gliomas; signaling pathways in GBMs; recurrent gliomas; midbrain gliomas; immunotherapy; targeted therapies for GBMs

(This special issue belongs to the Section Molecular Oncology)

Trace Elements, Metals and Bioactive Compounds: Homeostasis and Metabolic Impairment

edited by