Application of Mass Spectrometry and Chromatography in Drug Monitoring
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 871
Special Issue Editor
Interests: therapeutic drug monitoring; LC-MS method development; method validation; pharmacometrics; pediatric clinical pharmacology; HR-MS; laboratory developed tests; clinical mass spectrometry
Special Issue Information
Dear Colleagues,
Mass spectrometry (MS) in terms of clinical mass spectrometry arises great opportunities in clinical basic science and healthcare services. As the gold standard in pharmaceutical and clinical instrumental analytics, it serves as a powerful “tool” to encourage pharmacokinetic analysis of clinical studies/data and measurements for the individualization of pharmacotherapy of new drugs and metabolites in particular. Therefore, the scientists and staff members have to be familiar with regulatory affairs and use of fully validated in-house tests/laboratory-developed tests (LDTs) according to international valid regulations. Moreover, high-resolution mass spectrometry is the most promising technology for the detection and determination of the monoclonal antibody (mAb) structure, although the quantification of native proteins remains a challenge. The implementation of MS into a drug monitoring laboratory setting has the greatest potential to optimize actual immunotherapies with mAbs by far. Nevertheless, drug monitoring is not required for every drug. Measurement of drug levels is recommended based on national and international guidance documents. A drug monitoring service should be carried out in compliance with the indications and the need in the context of pharmacotherapy.
Prof. Dr. Carsten Müller
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- therapeutic drug monitoring
- method validation
- pharmacometrics
- pediatric clinical pharmacology
- laboratory developed tests
- clinical mass spectrometry
- functional tests
- isobars
- triple quad mass spectrometry
- HR-MS
- biomarker
- drugs of abuse
- therapeutic drugs
- metabolites
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
