Application of Mass Spectrometry and Chromatography in Drug Monitoring
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 September 2025 | Viewed by 685
Special Issue Editor
Interests: therapeutic drug monitoring; LC-MS method development; method validation; pharmacometrics; pediatric clinical pharmacology; HR-MS; laboratory developed tests; clinical mass spectrometry
Special Issue Information
Dear Colleagues,
Mass spectrometry (MS) in terms of clinical mass spectrometry arises great opportunities in clinical basic science and healthcare services. As the gold standard in pharmaceutical and clinical instrumental analytics, it serves as a powerful “tool” to encourage pharmacokinetic analysis of clinical studies/data and measurements for the individualization of pharmacotherapy of new drugs and metabolites in particular. Therefore, the scientists and staff members have to be familiar with regulatory affairs and use of fully validated in-house tests/laboratory-developed tests (LDTs) according to international valid regulations. Moreover, high-resolution mass spectrometry is the most promising technology for the detection and determination of the monoclonal antibody (mAb) structure, although the quantification of native proteins remains a challenge. The implementation of MS into a drug monitoring laboratory setting has the greatest potential to optimize actual immunotherapies with mAbs by far. Nevertheless, drug monitoring is not required for every drug. Measurement of drug levels is recommended based on national and international guidance documents. A drug monitoring service should be carried out in compliance with the indications and the need in the context of pharmacotherapy.
Prof. Dr. Carsten Müller
Guest Editor
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Keywords
- therapeutic drug monitoring
- method validation
- pharmacometrics
- pediatric clinical pharmacology
- laboratory developed tests
- clinical mass spectrometry
- functional tests
- isobars
- triple quad mass spectrometry
- HR-MS
- biomarker
- drugs of abuse
- therapeutic drugs
- metabolites
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