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Molecular Perspectives on the Synthesis and Application of Hydrogel Materials

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 20 October 2025 | Viewed by 1136

Special Issue Editor


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Guest Editor
Department of Chemical Engineering, Nanchang University, Nanchang 330031, China
Interests: separation; natural products; molecularly imprinted materials; preparation; characteristics; molecular recognition; chemical engineering; analytical chemistry; functional polymers
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Special Issue Information

Dear Colleagues,

Hydrogels are a kind of three-dimensional and cross-linked polymeric networks with properties such as hydrophilicity, softness, porosity, tunability, and nonpareil mechanical properties, and often they are stimulus-responsive. They are classified on different bases, such as methods of preparation, physical and chemical characteristics, as well as the technical feasibility of their utilization. In recent years, many different types of new hydrogels have been developed, and various techniques have been employed for hydrogel production, together with implications in the process design. With the progress of the hydrogel development, they have been and are widely used in different fields, such as drug delivery systems, sealing, artificial snow, pharmaceuticals, and several other biomedical applications, including tissue engineering, regenerative medicines, diagnostics, wound dressing, separation of biomolecules or cells, barrier materials to regulate biological adhesions, and biosensors. Several hydrogels with special properties have been prepared, but the molecular basis of their formation and the deriving properties are still under study. Nevertheless, the full elucidation of the application performance from the molecular perspective is important for hydrogels and needs further study.

This Special Issue focuses on the molecular basis of the hydrogels formation and application, on the possible new methods to synthesize hydrogels, and on the development of additional new hydrogels with special properties or application performance. We will welcome original research articles, comprehensive reviews, and novel communications.

Prof. Dr. Jieping Fan
Guest Editor

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Keywords

  • hydrogels
  • molecular basis
  • polymeric networks
  • supermolecular chemistry
  • three-dimensional structure
  • mechanical strength
  • rheologic properties
  • biomaterial

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Published Papers (1 paper)

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Research

18 pages, 4069 KiB  
Article
Fabricating a SFMA/BAChol/PAA/ZnCl2 Hydrogel with Excellent Versatile Comprehensive Properties and Stable Sensitive Freezing-Tolerant Conductivity for Wearable Sensors
by Jie-Ping Fan, Ming-Ru Xie, Chao Yuan, Jia Ma, Ke-Pu Fu, Chun-Hong Huang, Hui-Ping Chen, Hai-Long Peng and Chun-Fang Xie
Int. J. Mol. Sci. 2024, 25(24), 13339; https://doi.org/10.3390/ijms252413339 - 12 Dec 2024
Viewed by 831
Abstract
Flexible wearable sensors have obtained tremendous interest in various fields and conductive hydrogels are a promising candidate. Nevertheless, the insufficient mechanical properties, the low electrical conductivity and sensitivity, and the limited functional properties prevent the development of hydrogels as wearable sensors. In this [...] Read more.
Flexible wearable sensors have obtained tremendous interest in various fields and conductive hydrogels are a promising candidate. Nevertheless, the insufficient mechanical properties, the low electrical conductivity and sensitivity, and the limited functional properties prevent the development of hydrogels as wearable sensors. In this study, an SFMA/BAChol/PAA/ZnCl2 hydrogel was fabricated with high mechanical strength and versatile comprehensive properties. Specifically, the obtained hydrogel displayed excellent adhesion and mechanical stability, cryophylactic ability, stable sensitive freezing-tolerant conductivity, and feasible electrical conduction under a wide temperature range, demonstrating the high application potential as a flexible wearable sensor for movement behavior surveillance, even under harsh environments. Furthermore, the mechanical strength of the hydrogel could easily be regulated by varying the copolymer content. The molecular mechanisms of the hydrogel formation and the reversible adhesion during the wet-dry transition were proposed. The non-covalent interactions, including the electrostatic interaction, hydrogen bond interaction and hydrophobic association, and coordination interaction, were dynamically presented in the hydrogel network and hence supported the versatile comprehensive properties of the hydrogel. This study provides a strategy for designing novel hydrogels to promote the development of flexible sensors with stable sensitive freezing-tolerant conductivity. Full article
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