Trace Elements, Metals and Bioactive Compounds: Homeostasis and Metabolic Impairment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 299
Special Issue Editors
Interests: ketogenic diet; microRNAs signature; catalase; heavy metals metabolic effects; epigenetics; apoptosis; antioxidant effects
Special Issues, Collections and Topics in MDPI journals
Interests: bioenergetics; mitochondrial carriers; mutagenesis; drosophila melanogaster; mitochondrial diseases; mitochondrial dysfunction; apoptosis; ROS; antioxidant and anti-inflammatory activity; cancer metabolism; anticancer agents
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It is well known that the modulation of biochemical signaling pathways is a critical factor in the onset of several human diseases. In this context, trace elements, metals, and bioactive compounds can influence metabolic homeostasis, playing protective or negative roles for human health.Trace elements are required for cellular homeostasis, being involved in enzymatic activity, redox reactions, metabolism, signal transduction, protein folding, DNA replication, and the transport of electrons or other metabolites, thus playing important roles in the body.Heavy metals and metalloids impair cellular redox state and metabolism by inducing oxidative stress, damaging biomolecules, altering signal transduction, and causing apoptosis, protein misfolding, and malignant transformation. Their interference in signaling pathways affects metabolic processes, including glucose, protein, and lipid metabolism, along with adipogenesis, atherosclerosis, neurodegeneration, inflammation, etc. Bioactive compounds found in plants, animals, and microorganisms can influence metabolic pathways, exerting various effects (anti-inflammatory, antioxidant, antiviral, antimicrobial, antitumor, etc.) and can also interact with trace elements to modulate their effects.This Special Issue will focus on the targeted signaling pathways and related biological effects of these classes of molecules, highlighting how they modulate/alter cellular biochemical processes. We welcome submissions comprising original research manuscripts and reviews that focus on the metabolic implications of these molecules in human health and/or disease.
Dr. Graziantonio Lauria
Dr. Rosita Curcio
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- trace elements
- bioactive compounds
- metals
- human health
- human diseases
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
