Trace Elements, Metals and Bioactive Compounds: Homeostasis and Metabolic Impairment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 12
Special Issue Editors
Interests: ketogenic diet; microRNAs signature; catalase; heavy metals metabolic effects; epigenetics; apoptosis; antioxidant effects
Special Issues, Collections and Topics in MDPI journals
Interests: bioenergetics; mitochondrial carriers; mutagenesis; drosophila melanogaster; mitochondrial diseases; mitochondrial dysfunction; apoptosis; ROS; antioxidant and anti-inflammatory activity; cancer metabolism; anticancer agents
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
It is well known that the modulation of biochemical signaling pathways is a critical factor in the onset of several human diseases. In this context, trace elements, metals, and bioactive compounds can influence metabolic homeostasis, playing protective or negative roles for human health.Trace elements are required for cellular homeostasis, being involved in enzymatic activity, redox reactions, metabolism, signal transduction, protein folding, DNA replication, and the transport of electrons or other metabolites, thus playing important roles in the body.Heavy metals and metalloids impair cellular redox state and metabolism by inducing oxidative stress, damaging biomolecules, altering signal transduction, and causing apoptosis, protein misfolding, and malignant transformation. Their interference in signaling pathways affects metabolic processes, including glucose, protein, and lipid metabolism, along with adipogenesis, atherosclerosis, neurodegeneration, inflammation, etc. Bioactive compounds found in plants, animals, and microorganisms can influence metabolic pathways, exerting various effects (anti-inflammatory, antioxidant, antiviral, antimicrobial, antitumor, etc.) and can also interact with trace elements to modulate their effects.This Special Issue will focus on the targeted signaling pathways and related biological effects of these classes of molecules, highlighting how they modulate/alter cellular biochemical processes. We welcome submissions comprising original research manuscripts and reviews that focus on the metabolic implications of these molecules in human health and/or disease.
Dr. Graziantonio Lauria
Dr. Rosita Curcio
Guest Editors
Manuscript Submission Information
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Keywords
- trace elements
- bioactive compounds
- metals
- human health
- human diseases
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