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Exploring Amazon Bioactives: Novel Anti-Pathogen Therapeutics and Pharmaceutical Breakthroughs

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 April 2026 | Viewed by 2102

Special Issue Editors


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Guest Editor
Faculty of Pharmacy, Campus Profissional-UFPA, Rua Corrêa N°1, Belém 66075-900, PA, Brazil
Interests: Amazonian bio-compounds; resistant infectious agents; phenols; antioxidant activity; antimicrobial and anti-inflammatory; cytotoxicity, genotoxicity; animal toxicity

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Guest Editor
Faculty of Sanitary and Environmental Engineering, Campus Profissional-UFPA, Rua Corrêa N° 1, Belém 66075-900, PA, Brazil
Interests: thermochemical conversion of ligno-cellulosic biomass to produce bio-oils rich in phenolic compounds with biological (antioxidant activity, antimicrobial and anti-inflammatory) activity; biomass-to-energy; bio-oil to fuels
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Guest Editor
Departament of Health Sciences, Universidade Federal de Ciências da Saúde de Porto Alegre UFCSPA, Rua Sarmento Leite, 245, Centro Histórico, Porto Alegre 90050-170, RS, Brazil
Interests: experimental, preclinical or clinical research of plants; chemically characterized extracts, fractions, oils and isolated products on biological activity; pharmacological, toxicological and immunomodulatory properties

Special Issue Information

Dear Colleagues,

The purpose of this Special Issue, “Exploring Amazon Bioactives: Novel Anti-Pathogen Therapeutics and Pharmaceutical Breakthroughs”, is to present a collection of scientific manuscripts focusing the recent advances in prospection for Amazonian bio-compounds with potential action against emerging and/or resistant infectious agents to obtain pharmaceutical products. Topics of interest include but are not limited to chemical, biochemical and pharmacological properties and mechanisms of action of phytochemicals on pathogens such as viruses, bacteria and protozoa, among other pathogenic agents, in order to advance the discovery of new molecules with potential to generate new pharmaceutical products, conversion of biomass into bio-oils rich in phenolic compounds, physical–chemical properties and chemical composition of bio-oils.

Prof. Dr. Marta Chagas Monteiro
Prof. Dr. Nélio Teixeira Machado
Dr. Pedro Roosevelt Romão
Guest Editors

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Keywords

  • waste biomass
  • thermochemical processes
  • bio-oils
  • phenolic compounds
  • anti-inflammatory actions
  • antiviral mechanisms
  • cancer
  • cytokine/chemokine regulation
  • inflammatory conditions/diseases
  • innate immunity
  • immune response
  • immunomodulatory and anti-infective effects
  • immunomodulation
  • immunotoxicology
  • medicinal chemistry
  • neglected tropical diseases
  • parasitic disease
  • purinergic signaling

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Published Papers (1 paper)

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Research

27 pages, 6917 KB  
Article
Effect of Temperature and Molarity on the Evaluation of Antimicrobial, Cytotoxic, and Antioxidant Activities of the Bio-Oil from Açaí Seed (Euterpe oleracea Mart.)
by Iago Castro da Silva, Pamela Suelen da Silva Seabra, Kely Campos Navegantes Lima, Ricardo Barbosa Bezerra Filho, Alanna Lorena P. dos Santos, Amanda Caroline dos Santos Monteiro, Giovanna Quintero Pamplona, Alexandre Guilherme da Silva Dias, Rayane Caroline dos Santos Pereira, Leticia Araujo Costa, Thays Jhessica Mota Pinheiro, Lauro Henrique Hamoy Guerreiro, Nélio Teixeira Machado and Marta Chagas Monteiro
Int. J. Mol. Sci. 2025, 26(17), 8251; https://doi.org/10.3390/ijms26178251 - 26 Aug 2025
Viewed by 1241
Abstract
Açaí (Euterpe oleracea Mart.), a fruit from the Amazon, is valuable both economically and nutritionally. Its seeds, often discarded, can be transformed into bio-oil through pyrolysis (a thermochemical degradation process of residual biomass), providing a sustainable alternative to fossil fuels. This study [...] Read more.
Açaí (Euterpe oleracea Mart.), a fruit from the Amazon, is valuable both economically and nutritionally. Its seeds, often discarded, can be transformed into bio-oil through pyrolysis (a thermochemical degradation process of residual biomass), providing a sustainable alternative to fossil fuels. This study investigates how temperature and molarity influence the antimicrobial, antioxidant, and cytotoxic activities of the produced bio-oil. Various assays were performed on bio-oil samples obtained under different pyrolysis conditions—specifically, at temperatures of 350, 400, and 450 °C, and molarities of 0.5 M, 1.0 M, and 2.0 M—to evaluate antimicrobial, antioxidant, and cytotoxic activities. Gas chromatography–mass spectrometry (GC–MS) was used to analyze the composition, revealing that phenolic compounds were the most abundant (55.70%), followed by cyclic and aromatic hydrocarbons (11.89%), and linear hydrocarbons (9.64%). Despite a reduction in oxygenated compounds, the bio-oil maintained bacteriostatic activity against Escherichia coli and Staphylococcus aureus, especially at 350 °C. The antioxidant activity was highest at 350 °C and at lower molarities. Additionally, lower concentrations of acid impregnation showed cytotoxic effects at higher temperatures. Thus, bio-oil from açaí seeds produced via pyrolysis demonstrates potential for antioxidant and antimicrobial activities, suggesting viability for further testing at dilutions with lower cytotoxicity. Full article
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