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Biochemical Advancements in Filler Technology and Their Impact on Tissue Engineering

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (30 September 2025) | Viewed by 1043

Special Issue Editor


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Guest Editor
Division of Plastic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Interests: biomaterial‒host interactions; silk; biofilms; bacteria‒host interaction; chronic inflammation; rejection
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Special Issue Information

Dear Colleagues,

The integration of biochemical innovation in filler technology has unlocked new possibilities in the field of regenerative medicine and tissue engineering. From the modulation of cellular microenvironments to the bioactivation of scaffold materials, modern filler formulations now extend far beyond traditional cosmetic applications. These advancements are driven by cutting-edge research in molecular biology, polymer science, and bioengineering, resulting in materials that not only support tissue repair, but which actively participate in regeneration.

As the Guest Editor of this Special Issue of the International Journal of Molecular Sciences titled “Biochemical Advancements in Filler Technology and Their Impact on Tissue Engineering”, I invite contributions that explore the molecular mechanisms, clinical applications, and novel biomaterials that define this rapidly evolving domain. We welcome a broad range of article types including original research, reviews, short communications, perspectives, and methodologies that highlight the dynamic interface between molecular innovation and filler-based therapies for soft tissue repair and regeneration.

Dr. Samuel J. Lin
Guest Editor

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Keywords

  • biochemical filler technology
  • tissue regeneration
  • bioactive materials
  • injectable scaffolds
  • molecular signaling in tissue engineering
  • biomaterials for soft tissue repair
  • filler–cell interactions
  • regenerative esthetics

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Published Papers (1 paper)

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Review

30 pages, 2100 KB  
Review
Hydrogel-Based Vitreous Substitutes
by Soheil Sojdeh, Amirhosein Panjipour, Zahra Bibak Bejandi, Majid Salehi, Amal Yaghmour, Zohreh Arabpour, Ali R. Djalilian and R. V. Paul Chan
Int. J. Mol. Sci. 2025, 26(17), 8406; https://doi.org/10.3390/ijms26178406 - 29 Aug 2025
Cited by 1 | Viewed by 730
Abstract
Hydrogel-based vitreous substitutes have been considered as a potential solution for the treatment of retinal disorders, especially when the natural vitreous body is damaged due to trauma, disease, or surgery. With their high-water content, biocompatibility, and tunable mechanical properties, these hydrogels offer a [...] Read more.
Hydrogel-based vitreous substitutes have been considered as a potential solution for the treatment of retinal disorders, especially when the natural vitreous body is damaged due to trauma, disease, or surgery. With their high-water content, biocompatibility, and tunable mechanical properties, these hydrogels offer a promising alternative to traditional vitreous substitutes. This review explores the role of polymers and crosslinkers in the development of hydrogel-based substitutes, focusing on how these components contribute to the structure and function of hydrogels. The choice of natural polymers, such as hyaluronic acid and collagen, or synthetic ones, such as polyethylene glycol and polyvinyl alcohol, is crucial to mimic the transparency and flexibility of the vitreous body. Crosslinking methods, including physical, chemical, and enzymatic approaches, help control the gelation process and enhance the mechanical strength of the hydrogel. Furthermore, this review demonstrates how these hydrogels interact with biological tissues, which enhances biocompatibility, cell growth, and tissue repair. This review also discusses the challenges and future directions in improving these hydrogels, particularly in terms of long-term stability, integration with ocular tissues, and appropriate mechanical properties. Overall, hydrogel-based vitreous substitutes have significant potential to improve surgical outcomes and restore vision for patients with vitreous injury. Full article
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