Advancement of Understanding Alzheimer’s Disease Susceptibility and Novel Drug Targets
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 30 October 2025 | Viewed by 1280
Special Issue Editors
Interests: Alzheimer’s disease; tau; amyloid β; prion-like
Special Issues, Collections and Topics in MDPI journals
Interests: Alzheimer’s disease; tau; amyloid β
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
To date, there are over 55 million individuals globally living with dementia. This number will nearly double every 20 years, becoming a substantial social issue. Alzheimer's disease (AD) and related dementia (ADRD) are the major causes of dementia, leading to disability, dependence, and death among the elderly. In the last two decades, significant progress has been made in the understanding of the pathogenic mechanisms of AD and ADRD, providing a broad range of knowledge on various factors involved in AD etiology. Among them, disturbances of protein-degrading pathways have been implicated as key pathological mechanisms. These new findings have allowed us to improve the accuracy of disease diagnosis and to find novel potential therapeutic targets to develop disease-modifying drugs. The scope of this Special Issue is thus to explore the recent findings on the fundamental cellular signaling, biological factors involved in dysfunctions, and novel treatments for AD and ADRD.
Dr. Kunie Ando
Prof. Dr. Jean-Pierre Brion
Guest Editors
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Keywords
- Alzheimer’s disease
- neurodegenerative diseases
- tau
- amyloid
- inflammation
- disease modifying treatments
- biomarkers
- genetic variants
- risk factors
- mechanisms
- protein–protein interactions
- post-translational modifications
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