Pathogenic Proteins in Neurodegenerative Diseases: From Pathogenesis to Therapeutic Innovations
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 346
Special Issue Editors
Interests: neurological disorders; mental illnesses; autism; genetically engineered mouse models
Interests: neurodegenerative diseases; neurotherapeutics; neuro-proteinopathies; Alzheimer’s disease; therapeutic molecules; neurotrophin signaling; neurotrophic factor; neurodevelopmental disorder
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Special Issue Information
Dear Colleagues,
Neurodegenerative diseases are increasingly recognized as significant social challenges across many countries. A common pathogenic feature these disorders share is the accumulation of misfolded and aggregated proteins within the brain. Since most neurodegenerative diseases are characterized as proteinopathies, a primary therapeutic strategy involves the removal of these harmful proteins from brain tissue. This book will explore the multifaceted roles of neuroproteins in the development of neurological disorders and investigate innovative therapeutic strategies targeting neuroprotein dysfunction. We invite submissions that delve into the molecular mechanisms of neuroprotein misfolding and aggregation, as well as advances in identifying and validating neuroprotein biomarkers.
We are also interested in research on RNA-based and gene-editing therapeutics, the effects of neuroprotein-related epigenetic changes, and the application of high-throughput proteomic techniques. Contributions to small molecule and protein-based treatments are welcome, alongside studies on the role of neuroproteins in immunological interactions, stroke, neuroinflammation, and traumatic brain injury. Additionally, we encourage articles that present new findings from preclinical models and clinical trials focused on neuroprotein pathways. We invite contributions that enhance our understanding of neuroproteins from both functional and pathological perspectives.
Dr. Minseok Song
Dr. Nidhi Puranik
Guest Editors
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Keywords
- Alzheimer’s disease
- Parkinson’s disease
- amyotrophic lateral sclerosis
- frontotemporal dementia
- lewy bodies dementia
- amyloid β-protein
- τ-protein
- α-synuclein
- TDP-43
- neurotransmitter
- neuropeptide
- protein misfolding
- protein Homeostasis
- neuroinflammatory proteins
- post-translational modifications
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